sTREM-1 and TNF-α levels are associated with the clinical outcome of leprosy patients

被引：3

作者：

Bezerra-Santos, Marcio ^{[1
,2
,3
]}

Bomfim, Lays G. Santos ^{[2
,3
]}

Santos, Camilla N. Oliveira ^{[2
,3
]}

Cunha, Maria Wiliane N. ^{[2
]}

de Moraes, Eduardo J. Rocha ^{[2
]}

Cazzaniga, Rodrigo A. ^{[2
,3
]}

Tenorio, Martha D. L. ^{[3
,4
]}

Araujo, Jonnia M. Sherlock ^{[3
,4
]}

Menezes-Silva, Lucas ^{[2
]}

Magalhaes, Lucas Sousa ^{[2
,3
]}

Barreto, Aline S. ^{[2
,3
]}

Reed, Steven G. ^{[5
]}

Duthie, Malcolm S. ^{[5
]}

Lipscomb, Michael W. ^{[6
]}

de Almeida, Roque Pacheco ^{[2
,3
,7
,8
]}

de Moura, Tatiana Rodrigues ^{[2
,3
]}

de Jesus, Amelia Ribeiro ^{[2
,3
,7
,8
]}

机构：

[1] Univ Fed Alagoas, Ctr Ciencias Med & Enfermagem, Maceio, Brazil

[2] Univ Fed Sergipe, Lab Imunol & Biol Mol, Aracaju, Brazil

[3] Univ Fed Sergipe, Programa Posgrad Ciencias Saude, Aracaju, Brazil

[4] Univ Fed Sergipe, Hosp Univ, Dept Dermatol, Aracaju, Brazil

[5] Host Directed Therapeut HDT Bio Corp, Seattle, WA USA

[6] Univ Minnesota, Dept Pharmacol, Minneapolis, MN USA

[7] Univ Fed Sergipe, Dept Med, Aracaju, Brazil

[8] Conselho Nacl Pesquisa & Tecnol CNPq, Inst Invest Imunol 3, Inst Nacionais Ciencia & Tecnol INCTs, Sao Paulo, Brazil

来源：

FRONTIERS IN MEDICINE | 2023年 / 10卷

关键词：

leprosy; soluble TREM-1; inflammatory cytokine; immune markers; leprosy complications; GENE POLYMORPHISMS; MYELOID CELLS-1; TREM-1; SEPSIS; TLR;

D O I：

10.3389/fmed.2023.1177375

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Leprosy reaction (LR) and physical disability (PD) are the most significant clinical complications of leprosy. Herein, we assessed the circulating serum-sTREM-1 and TNF-& alpha; levels and their genetic polymorphisms in leprosy. Serum-sTREM-1 and TNF-& alpha; levels were measured in leprosy patients (LP) before treatment (n = 51) and from their household contacts (HHCs; n = 25). DNA samples were genotyped using TREM-1 rs2234246 and TNF-& alpha; rs1800629-SNP in 210 LPs and 168 endemic controls. The circulating sTREM-1 and TNF-& alpha; levels are higher in the multibacillary form. The ROC curve of the serum-sTREM-1 levels was able to differentiate LR from non-LR and PD from non-PD. Similarly, LPs with serum-sTREM-1 levels >210 pg/ml have 3-fold and 6-fold higher chances of presenting with LR and PD, respectively. Genotypes CC+CT of the TREM-1 were associated with leprosy. Taken together, our analyses indicated that sTREM-1 and TNF-& alpha; play an important role in the pathogenesis of leprosy and provide promising biomarkers to assist in the diagnosis of leprosy complications.

引用

页数：8

共 35 条

[1] Association of IL10 Polymorphisms and Leprosy: A Meta-Analysis [J].

Alvarado-Arnez, Lucia Elena ;

Amaral, Evaldo P. ;

Sales-Marques, Carolinne ;

Duraes, Sandra M. B. ;

Cardoso, Cynthia C. ;

Sarno, Euzenir Nunes ;

Pacheco, Antonio G. ;

Lana, Francisco C. F. ;

Moraes, Milton Ozorio .

PLOS ONE, 2015, 10 (09)

[2]

[Anonymous], 2017, Wkly Epidemiol Rec, V92, P501

[3]

[Anonymous], GUID DIAGN TREATM PR

[4] TREM-1 SNP rs2234246 regulates TREM-1 protein and mRNA levels and is associated with plasma levels of L-selectin [J].

Arguinano, Alex-Ander Aldasoro ;

Dade, Sebastien ;

Stathopoulou, Maria ;

Derive, Marc ;

Ndiaye, Ndeye Coumba ;

Xie, Ting ;

Masson, Christine ;

Gibot, Sebastien ;

Visvikis-Siest, Sophie .

PLOS ONE, 2017, 12 (08)

[5] Position statement: LEPROSY: Diagnosis, treatment and follow-up [J].

Belachew, W. Alemu ;

Naafs, B. .

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2019, 33 (07) :1205-1213

[6] Mycobacterium leprae Recombinant Antigen Induces High Expression of Multifunction T Lymphocytes and Is Promising as a Specific Vaccine for Leprosy [J].

Bezerra-Santos, Marcio ;

do Vale-Simon, Marise ;

Barreto, Aline Silva ;

Cazzaniga, Rodrigo Anselmo ;

de Oliveira, Daniela Teles ;

Barrios, Monica Rueda ;

Ferreira, Alex Ricardo ;

Santos-Bio, Nanci C. ;

Reed, Steven G. ;

de Almeida, Roque Pacheco ;

Correa, Cristiane Bani ;

Duthie, Malcolm S. ;

de Jesus, Amelia Ribeiro .

FRONTIERS IN IMMUNOLOGY, 2018, 9

[7] Leishmania infantum Induces the Release of sTREM-1 in Visceral Leishmaniasis [J].

Bomfim, Lays G. S. ;

Magalhaes, Lucas S. ;

Santos-Filho, Marcello A. A. ;

Peres, Nalu T. A. ;

Correa, Cristiane B. ;

Tanajura, Diego M. ;

Silva, Angela M. ;

Lipscomb, Michael W. ;

Borges, Valeria M. ;

Jesus, Amelia R. ;

Almeida, Roque P. ;

de Moura, Tatiana R. .

FRONTIERS IN MICROBIOLOGY, 2017, 8

[8] Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1): a potential biomarker for the diagnosis of infectious diseases [J].

Cao, Changlin ;

Gu, Jingxian ;

Zhang, Jingyao .

FRONTIERS OF MEDICINE, 2017, 11 (02) :169-177

[9] sTREM-1 Predicts Disease Severity and Mortality in COVID-19 Patients: Involvement of Peripheral Blood Leukocytes and MMP-8 Activity [J].

da Silva-Neto, Pedro V. ;

de Carvalho, Jonatan C. S. ;

Pimentel, Vinicius E. ;

Perez, Malena M. ;

Toro, Diana M. ;

Fraga-Silva, Thais F. C. ;

Fuzo, Carlos A. ;

Oliveira, Camilla N. S. ;

Rodrigues, Lilian C. ;

Argolo, Jamille G. M. ;

Carmona-Garcia, Ingryd ;

Neto, Nicola T. ;

Souza, Camila O. S. ;

Fernandes, Talita M. ;

Bastos, Victor A. F. ;

Degiovani, Augusto M. ;

Constant, Leticia F. ;

Ostini, Fatima M. ;

Feitosa, Marley R. ;

Parra, Rogerio S. ;

Vilar, Fernando C. ;

Gaspar, Gilberto G. ;

da Rocha, Jose J. R. ;

Feres, Omar ;

Frantz, Fabiani G. ;

Gerlach, Raquel F. ;

Maruyama, Sandra R. ;

Russo, Elisa M. S. ;

Viana, Angelina L. ;

Fernandes, Ana P. M. ;

Santos, Isabel K. F. M. ;

Bonato, Vania L. D. ;

Boechat, Antonio L. ;

Malheiro, Adriana ;

Sadikot, Ruxana T. ;

Dias-Baruffi, Marcelo ;

Cardoso, Cristina R. B. ;

Faccioli, Lucia H. ;

Sorgi, Carlos A. .

VIRUSES-BASEL, 2021, 13 (12)

[10] Polymorphisms in the TGFB1 and IL2RA genes are associated with clinical forms of leprosy in Brazilian population [J].

de Camargo, Rodrigo Mendes ;

da Silva, Weber Laurentino ;

Medeiros, Priscila ;

Fernandes Belone, Andrea de Faria ;

Pereira Latini, Ana Carla .

MEMORIAS DO INSTITUTO OSWALDO CRUZ, 2018, 113 (12)

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