From Obesity-Induced Low-Grade Inflammation to Lipotoxicity and Mitochondrial Dysfunction: Altered Multi-Crosstalk between Adipose Tissue and Metabolically Active Organs

被引：32

作者：

Cavaliere, Gina ^{[1
,2
]}

Cimmino, Fabiano ^{[2
,3
]}

Trinchese, Giovanna ^{[3
]}

Catapano, Angela ^{[2
,3
]}

Petrella, Lidia ^{[3
]}

D'Angelo, Margherita ^{[3
]}

Lucchin, Lucio ^{[4
]}

Mollica, Maria Pina ^{[2
,3
,5
]}

机构：

[1] Univ Perugia, Dept Pharmaceut Sci, I-06126 Perugia, Italy

[2] Complesso Univ Monte St Angelo, Ctr Servizi Metrol & Tecnol Avanzati CeSMA, I-80126 Naples, Italy

[3] Univ Naples Federico II, Dept Biol, I-80126 Naples, Italy

[4] Bolzano Hlth Dist, Dietet & Clin Nutr, I-39100 Bolzano, Italy

[5] Univ Naples Federico II, Task Force Microbiome Studies, I-80138 Naples, Italy

来源：

ANTIOXIDANTS | 2023年 / 12卷 / 06期

关键词：

adipose tissue dysfunction; hypertrophy adipocytes; metabolic diseases; neurodegenerative disorders; mitochondria; bioactive compounds; NONALCOHOLIC FATTY LIVER; INDUCED INSULIN-RESISTANCE; DIET-INDUCED OBESE; OXIDATIVE STRESS; PROTEIN-KINASE; LIPID-ACCUMULATION; IRON-DEFICIENCY; DONKEY MILK; SUBSTRATE METABOLISM; MOLECULAR-MECHANISMS;

D O I：

10.3390/antiox12061172

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Obesity is a major risk factor for several metabolic diseases, including type 2 diabetes, hyperlipidemia, cardiovascular diseases, and brain disorders. Growing evidence suggests the importance of inter-organ metabolic communication for the progression of obesity and the subsequent onset of related disorders. This review provides a broad overview of the pathophysiological processes that from adipose tissue dysfunction leading to altered multi-tissue crosstalk relevant to regulating energy homeostasis and the etiology of obesity. First, a comprehensive description of the role of adipose tissue was reported. Then, attention was turned toward the unhealthy expansion of adipose tissue, low-grade inflammatory state, metabolic inflexibility, and mitochondrial dysfunction as root causes of systemic metabolic alterations. In addition, a short spot was devoted to iron deficiency in obese conditions and the role of the hepcidin-ferroportin relationship in the management of this issue. Finally, different classes of bioactive food components were described with a perspective to enhance their potential preventive and therapeutic use against obesity-related diseases.

引用

页数：23

共 228 条

[81] Mitochondrial Dysfunction in Neurodegenerative Diseases [J].