Trends in Antibiotic Resistance of Nosocomial and Community-Acquired Infections in Italy

被引:19
作者
Cerini, Paola [1 ]
Meduri, Francesca Rita [1 ,2 ]
Tomassetti, Flaminia [1 ,3 ]
Polidori, Isabella [1 ]
Brugneti, Marta [1 ,4 ]
Nicolai, Eleonora [3 ]
Bernardini, Sergio [3 ,5 ]
Pieri, Massimo [3 ,5 ]
Broccolo, Francesco [1 ,6 ]
机构
[1] Cerba Healthcare Italia Srl, Viale Roma 190-A, I-00012 Rome, Italy
[2] Univ Roma La Sapienza, Dept Mol Med, Microbiol & Virol Lab, I-00185 Rome, Italy
[3] Univ Roma Tor Vergata, Dept Expt Med, Biochem Lab, I-00133 Rome, Italy
[4] Univ Roma Tor Vergata, Dept Expt Med, Microbiol & Virol Lab, I-00133 Rome, Italy
[5] Tor Vergata Univ Hosp, Dept Lab Med, Viale Oxford 81, I-00133 Rome, Italy
[6] Univ Salento, Dept Biol & Environm Sci & Technol DiSTeBA, I-73100 Lecce, Italy
来源
ANTIBIOTICS-BASEL | 2023年 / 12卷 / 04期
关键词
antibiotic resistance; nosocomial infections; community infections; EPIDEMIOLOGY; HEALTH;
D O I
10.3390/antibiotics12040651
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
The World Health Organization has recently identified three categories of pathogens, namely: critical, high, and medium priority, according to the need for new antibiotics. Critical priority pathogens include carbapenem-resistant microorganism (CPO) such as A. baumannii and P. aeruginosa, K. pneumoniae, and Enterobacter spp., whereas vancomycin-resistant E. faecium (VRE), methicillin and vancomycin-resistant S. aureus (MRSA) are in the high priority list. We compared the trend of antimicrobial resistants (AMRs) in clinical isolates, divided by year and bacteria spp., of samples obtained from nosocomial and community patients. Patient records were collected, including age, sex, site of infection, isolated organisms, and drug susceptibility patterns. From 2019 to 2022, a total of 113,635 bacterial isolates were tested, of which 11,901 resulted in antimicrobial resistants. An increase in the prevalence of several antibiotics resistant bacteria was observed. Specifically, the percentage of CPO cases increased from 2.62% to 4.56%, the percentage of MRSA increased from 1.84% to 2.81%, and the percentage of VRE increased from 0.58% to 2.21%. AMRs trend resulted in increases in CPO and MRSA for both community and nosocomial. Our work aims to highlight the necessity of preventive and control measures to be adopted in order to reduce the spread of multidrug-resistant pathogens.
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页数:11
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