Comparing Hearing Loss in Children with Adults Living with Sickle Cell Disease and Sickle Cell Traits

被引:0
作者
Ibekwe, T. S. [1 ,3 ]
Rogers, C. [2 ]
Ramma, L. [2 ]
机构
[1] Univ Abuja, Dept Otorhinolaryngol, Abuja, South Africa
[2] Univ Cape Town, Dept Hlth & Rehabil Sci, Div Commun Sci & Disorders, Cape Town, South Africa
[3] Univ Cape Town, Dept Commun Sci, Cape Town, South Africa
关键词
Audiometry; genotype; hearing loss; sickle cell disease; sickle cell trait; NIGERIAN CHILDREN;
D O I
10.4103/njcp.njcp_763_23
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background:Hearing loss is a neurological sequelae associated with sickle cell disease (SCD) and probably sickle cell trait (SCT) in children and adults but remains understudied.Aim:This study aimed to compare the hearing impairment among children and adults living with SCD or SCT.Methods:A comparative cross-sectional study conducted in four departments with SCD outpatient clinic in a tertiary hospital in Nigeria. Participants with Sickle cell disease (HbSS) and Sickle cell trait (HbAS) (cohort) and HbAA (control) had comprehensive ear and hearing assessments for sensorineural hearing loss. Audiometric results were categorized according to WHO classifications and data analysed with Statistical Analysis System (SAS 9.4).Results:A total of 212 participants (106 cohort and control, respectively), aged 6 months to 55 years, were enrolled. Of these, 35% of children with SCD and 25% with SCT had hearing impairment, while 30% of adults with SCD, 36.1% with SCT, and 11% with HbAA had hearing impairment. There was asymmetry in the hearing impairment, with the left ear more affected in children and the right ear in adults. The odds ratio (OD) of hearing impairment was higher in HbSS (2.48 (95% confidence interval (CI):1.51-4.14); P = 0.0004) and HbAS (2.28 (95% CI: 1.1-4.58); P = 0.02) participants compared with HbAA but was not statistically significant when adjusted for frequency of hospitalization, crises, blood transfusion and routine drugs in HbAS (P = 0.49) unlike HbSS (P = 0.03).Conclusion:The prevalence of hearing loss among children and adults with SCD is higher than in those with HbA genotype. The frequency of hospitalization, crises, blood transfusion and taking routine drugs may influence hearing impairment in SCT but may not in SCD.
引用
收藏
页码:74 / 81
页数:8
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