Tracheal replacement with aortic grafts: Bench to clinical practice

被引:7
作者
Wei, Shixiong [1 ,2 ]
Yang, Bo [1 ]
Bi, Taiyu [1 ]
Zhang, Wenyu [1 ]
Sun, He [1 ]
Cui, Yongsheng [1 ]
Li, Guanghu [1 ,5 ]
Zhang, Anling [3 ,4 ]
机构
[1] First Hosp Jilin Univ, Dept Thorac Surg, Changchun 130021, Jilin, Peoples R China
[2] First Hosp Jilin Univ, Gen Surg Ctr, Dept Hepatobiliary & Pancreat Surg, Changchun 130021, Jilin, Peoples R China
[3] Jilin FAW Gen Hosp, Dept Maxillofacial Surg, Changchun 130000, Jilin, Peoples R China
[4] 2643 Dongfeng Rd, Changchun 130000, Jilin, Peoples R China
[5] 1 Xinmin Rd, Changchun 130021, Chin, Myanmar
关键词
Airway replacement; Aortic graft; Surgical technique; Tissue engineering; Mesenchymal stem cells; TISSUE; REGENERATION; TRANSPLANTATION; AUTOGRAFT;
D O I
10.1016/j.reth.2023.09.004
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Tracheal reconstruction following extensive resection for malignant or benign lesions remains a major challenge in thoracic surgery. Numerous studies have attempted to identify the optimal tracheal replacement with different biological or prosthetic materials, such as various homologous and autologous tissues, with no encouraging outcomes. Recently, a few clinical studies reported attaining favorable outcomes using in vitro or stem cell-based airway engineering and also with tracheal allograft implantation following heterotopic revascularization. However, none of the relevant studies offered a standardized technology for airway replacement. In 1997, a novel approach to airway reconstruction was proposed, which involved using aortic grafts as the biological matrix. Studies on animal models reported achieving in-vivo cartilage and epithelial regeneration using this approach. These encouraging results inspired the subsequent application of cryopreserved aortic allografts in humans for the first time. Cryopreserved aortic allografts offered further advantages, such as easy availability in tissue banks and no requirement for immunosuppressive treatments. Currently, stented aortic matrix-based airway replacement has emerged as a standard approach, and its effectiveness was also verified in the recently reported TRITON-01 study. In this context, the present review aims to summarize the current status of the application of aortic grafts in tracheal replacement, including the latest advancements in experimental and clinical practice. (c) 2023, The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
引用
收藏
页码:434 / 442
页数:9
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