Mechanisms of endothelial flow sensing

被引：20

作者：

Aitken, Claire ^{[1
]}

Mehta, Vedanta ^{[1
]}

Schwartz, Martin A. ^{[2
,3
]}

Tzima, Ellie ^{[1
]}

机构：

[1] Univ Oxford, Wellcome Ctr Human Genet, Radcliffe Dept Med, Oxford, England

[2] Yale Univ, Yale Cardiovasc Res Ctr, Dept Internal Med, Sect Cardiovasc Med, New Haven, CT 06520 USA

[3] Yale Univ, Dept Cell Biol & Biomed Engn, New Haven, CT 06520 USA

来源：

NATURE CARDIOVASCULAR RESEARCH | 2023年 / 2卷 / 06期

基金：

英国惠康基金;

关键词：

FLUID SHEAR-STRESS; CELL-ADHESION MOLECULE-1; RECTIFYING K+ CHANNELS; NITRIC-OXIDE PRODUCTION; PRIMARY CILIA; VE-CADHERIN; HEPARAN-SULFATE; CA2+ INFLUX; MESENCHYMAL TRANSITION; VASCULAR INFLAMMATION;

D O I：

10.1038/s44161-023-00276-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Fluid shear stress plays a key role in sculpting blood vessels during development, in adult vascular homeostasis and in vascular pathologies. During evolution, endothelial cells evolved several mechanosensors that convert physical forces into biochemical signals, a process termed mechanotransduction. This Review discusses our understanding of endothelial flow sensing and suggests important questions for future investigation. Aitken and colleagues discuss the current understanding of how endothelial cells sense blood flow, focusing on the mechanosensing and mechanotransduction molecules and mechanisms, and highlighting challenges and outstanding questions that should lead future research efforts.

引用

页码：517 / 529

页数：13

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