COVID-19 convalescent plasma therapy decreases inflammatory cytokines: a randomized controlled trial

被引：4

作者：

Habtehyimer, Feben ^{[1
]}

Zhu, Xianming ^{[2
]}

Redd, Andrew D. ^{[1
,3
]}

Gebo, Kelly A. ^{[1
]}

Abraham, Alison G. ^{[4
]}

Patel, Eshan U. ^{[5
]}

Laeyendecker, Oliver ^{[3
]}

Gniadek, Thomas J. ^{[6
]}

Fernandez, Reinaldo E. ^{[1
]}

Baker, Owen R. ^{[1
]}

Ram, Malathi ^{[7
]}

Cachay, Edward R. ^{[8
]}

Currier, Judith S. ^{[9
]}

Fukuta, Yuriko ^{[10
]}

Gerber, Jonathan M. ^{[11
]}

Heath, Sonya L. ^{[12
]}

Meisenberg, Barry ^{[13
]}

Huaman, Moises A. ^{[14
]}

Levine, Adam C. ^{[15
]}

Shenoy, Aarthi ^{[16
]}

Anjan, Shweta ^{[17
]}

Blair, Janis E. ^{[18
]}

Cruser, Daniel ^{[19
]}

Forthal, Donald N. ^{[20
]}

Hammitt, Laura L. ^{[7
]}

Kassaye, Seble ^{[21
]}

Mosnaim, Giselle S. ^{[22
]}

Patel, Bela ^{[23
]}

Paxton, James H. ^{[24
]}

Raval, Jay S. ^{[25
]}

Sutcliffe, Catherine G. ^{[7
]}

Abinante, Matthew ^{[26
]}

Oei, Kevin S. ^{[26
]}

Cluzet, Valerie ^{[27
]}

Cordisco, Marie Elena ^{[28
]}

Greenblatt, Benjamin ^{[29
]}

Rausch, William ^{[28
]}

Shade, David ^{[5
]}

Gawad, Amy L. ^{[30
]}

Klein, Sabra L. ^{[30
]}

Pekosz, Andrew ^{[30
]}

Shoham, Shmuel ^{[1
]}

Casadevall, Arturo ^{[30
]}

Bloch, Evan M. ^{[2
]}

Hanley, Daniel ^{[31
]}

Tobian, Aaron A. R. ^{[2
]}

Sullivan, David J. ^{[30
]}

机构：

[1] Johns Hopkins Univ, Johns Hopkins Sch Med, Dept Med, Div Infect Dis, Baltimore, MD USA

[2] Johns Hopkins Univ, Johns Hopkins Sch Med, Dept Pathol, Baltimore, MD USA

[3] NIAID, Div Intramural Res, NIH, Rockville, MD 20892 USA

[4] Univ Colorado, Dept Epidemiol, Anschutz Med Campus, Aurora, CO USA

[5] Johns Hopkins Univ, Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[6] Northshore Univ Hlth Syst, Dept Pathol & Lab Med, Evanston, IL USA

[7] Johns Hopkins Univ, Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD USA

[8] Univ Calif San Diego, Dept Med, Div Infect Dis, San Diego, CA USA

[9] Univ Calif Los Angeles, Dept Med, Div Infect Dis, Los Angeles, CA USA

[10] Baylor Coll Med, Dept Med, Sect Infect Dis, Houston, TX USA

[11] Univ Massachusetts, Dept Med, Div Hematol & Oncol, Chan Med Sch, Worcester, MA USA

[12] Univ Alabama Birmingham, Div Infect Dis, Dept Med, Birmingham, AL USA

[13] Inst Luminis Hlth, Dept Med & Res, Annapolis, MD USA

[14] Univ Cincinnati, Dept Med, Div Infect Dis, Cincinnati, OH USA

[15] Brown Univ, Warren Alpert Med Sch, Dept Emergency Med, Providence, RI USA

[16] MedStar Washington Hosp Ctr, Dept Med, Div Hematol & Oncol, Washington, DC USA

[17] Univ Miami, Miller Sch Med, Dept Med, Div Infect Dis, Miami, FL USA

[18] Mayo Clin Hosp, Dept Med, Div Infect Dis, Phoenix, AZ USA

[19] Nuvance Hlth Vassar Bros Med Ctr, Dept Pathol, Poughkeepsie, NY USA

[20] Univ Calif Irvine, Dept Med, Div Infect Dis, Irvine, CA USA

[21] Georgetown Univ, Med Ctr, Div Infect Dis, Washington, DC USA

[22] Northshore Univ Hlth Syst, Dept Med, Div Allergy & Immunol, Evanston, IL USA

[23] Univ Texas Hlth Sci Ctr Houston, Dept Med, Div Pulm, Houston, TX USA

[24] Wayne State Univ, Dept Emergency Med, Detroit, MI USA

[25] Univ New Mexico, Dept Pathol, Albuquerque, NM USA

[26] Ascada Res, Fullerton, CA USA

[27] Nuvance Hlth Vassar Bros Med Ctr, Dept Infect Dis, Poughkeepsie, NY USA

[28] Nuvance Hlth Danbury Hosp, Danbury, CT USA

[29] Nuvance Hlth Norwalk Hosp, Norwalk, CT USA

[30] Johns Hopkins Univ, Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD USA

[31] Johns Hopkins Univ, Johns Hopkins Sch Med, Dept Neurol, Brain Injury Outcomes Div, Baltimore, MD USA

来源：

MICROBIOLOGY SPECTRUM | 2024年 / 12卷 / 01期

关键词：

COVID-19; serotherapy; convalescent plasma; SARS-CoV-2; cytokines; chemokines; randomized trial; CORONAVIRUS DISEASE 2019; INTERLEUKIN-6; SEVERITY; REVEALS; IL-6;

D O I：

10.1128/spectrum.03286-23

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Early COVID-19 convalescent plasma (CCP) transfusion to outpatients with COVID-19 decreases progression to hospitalization, but the mechanism of how CCP reduces severity is unknown. Among 882 COVID-19 participants transfused with CCP or control plasma in a randomized controlled trial, 21 cytokines and chemokines were measured using electrochemiluminescence assays. Wilcoxon rank sum tests were used to evaluate the difference between early (transfused within 5 days of symptom onset) CCP vs early control plasma and late (transfused 6-9 days after symptom onset) CCP vs late control plasma at each visit. Linear mixed-effect models were used to assess the difference in the slope of cytokine change. Median cytokine and chemokine levels were similar between the early CCP and early control groups pre-transfusion. At the day 14 visit, only the median IL-6 (P = 0.014) and IL-16 (P = 0.036) levels were lower in the early CCP group compared to the early control group, but these differences were not statistically significant after correcting for multiple comparisons (requiring P < 0.0024). IL-6 levels decreased significantly faster in the early CCP group from screening to the day 14 visit compared to the early control group (P < 0.001). No difference was observed in the slope of cytokine change from screening to day 90 between early CCP and early control groups. Late control and late CCP arms showed similar cytokine and chemokine levels through study follow-up. One mechanism by which early CCP transfusion reduces hospitalization may be by decreasing IL-6 levels, as the reduction is associated with better recovery from COVID-19.

引用

页数：9

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