Active versus expectant management for premature rupture of membranes at term: A randomized, controlled study

被引：1

作者：

Awkadigwe, Fredrick I. ^{[1
]}

Ezugwu, Frank O. ^{[1
]}

Eleje, George U. ^{[2
,3
]}

Nweze, Sylvester O. ^{[1
]}

Odugu, Boniface U. ^{[1
]}

Dinwoke, Victor O. ^{[1
]}

Olu, Ephraim A. ^{[1
]}

Ortuanya, Kelvin E. ^{[1
]}

Ezenwaeze, Malachy N. ^{[1
]}

Eze, Obiechina C. ^{[1
]}

Onyekpa, Johnson I. ^{[1
]}

Ofor, Ifeanyichukwu J. ^{[1
]}

Onah, Osmond O. ^{[1
]}

Omeje, Chimdalu U. ^{[1
]}

Ezike, Andre U. ^{[1
]}

Enyinna, Perpetua K. ^{[1
]}

Malachy, Divinefavour E. ^{[3
]}

Okafor, Chigozie G. ^{[2
]}

机构：

[1] Enugu State Univ Sci & Technol ESUT, Teaching Hosp, Dept Obstet & Gynaecol, Parklane, Enugu, Nigeria

[2] Nnamdi Azikiwe Univ, Dept Obstet & Gynaecol, Teaching Hosp NAUTH, PMB 5025, Nnewi 435101, Anambra State, Nigeria

[3] Nnamdi Azikiwe Univ, Dept Obstet & Gynaecol, Effect Care Res Unit, Nnewi Campus, Awka, Nigeria

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2023年 / 51卷 / 08期

关键词：

PROM; Prostaglandin-E1; analogue; expectant management; active management; Premature rupture of membranes; PRETERM PRELABOR RUPTURE; PLACENTAL ALPHA-MICROGLOBULIN-1; FETAL MEMBRANES; NITRAZINE TEST; DIAGNOSIS; LABOR; INFECTION; PREGNANCY; INDUCTION; PROM;

D O I：

10.1177/03000605231195451

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

ObjectiveTo compare the effects on feto-maternal outcomes of expectant versus active management for premature rupture of membranes (PROM) at term.MethodsThis was a prospective randomized (1:1) controlled study involving 86 pregnant-women who received either expectant management (n = 43) or active management with misoprostol (n = 43) for PROM at term. Primary outcome was route of delivery. Secondary outcomes were: PROM to presentation interval; latency period; PROM to delivery interval; recruitment to delivery interval; labour and delivery complications.ResultsBaseline-characteristics were similar between groups. There was no significant difference between active and expectant groups in mean PROM to presentation/admission, or PROM to delivery. However, mean latency period (11.1 & PLUSMN; 7.3 hours vs 8.8 & PLUSMN; 5.5 hours) and mean recruitment to delivery intervals after PROM (14.7 & PLUSMN; 5.2 hours vs 11.8 & PLUSMN; 5.0 hours) were significantly shorter for the active group compared with the expectant group. Although the rate of caesarean section was less in expectant management group (21%) compared with the active management group (30%), the difference was not statistically significant. There were no significant differences between groups in delivery or perinatal complications.ConclusionActive and expectant management for PROM at term gave comparable outcomes in terms of methods of delivery and complications. However, active management significantly shortened the latency period and induction to delivery intervals compared with expectant management.Trial-Registration: Pan-African-trial-registry-(PACTR)-approval-number PACTR202206797734088ConclusionActive and expectant management for PROM at term gave comparable outcomes in terms of methods of delivery and complications. However, active management significantly shortened the latency period and induction to delivery intervals compared with expectant management.Trial-Registration: Pan-African-trial-registry-(PACTR)-approval-number PACTR202206797734088

引用

页数：14

共 40 条

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