Cuproptosis-Related Ferroptosis genes for Predicting Prognosis in kidney renal clear cell carcinoma

被引：10
作者：
Luo, Gang [1 ]
Wang, Lini [1 ]
Zheng, Ziyu [1 ]
Gao, Baobao [1 ]
Lei, Chong [1 ]
机构：
[1] Fourth Mil Med Univ, Xijing Hosp, Dept Anesthesiol & Perioperat Med, Xian 710032, Peoples R China
来源：
EUROPEAN JOURNAL OF MEDICAL RESEARCH | 2023年 / 28卷 / 01期
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
Signature; Clear Cell Renal Cell Carcinoma; Cuproptosis; Ferroptosis; CANCER-CELLS; SERUM-LEVELS; TRACE-ELEMENTS; COPPER; IRON; METABOLISM; SIGNATURE; DEATH; INHIBITION; APOPTOSIS;
D O I：
10.1186/s40001-023-01137-z
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Kidney renal clear cell carcinoma (KIRC) is a main subtype of kidney cancers. Cuproptosis and ferroptosis are correlated with immune infiltration and prognosis in tumors. However, the role of Cuproptosis-related Ferroptosis genes (CRFGs) in KIRC has rarely been fully understood. Therefore, we constructed a prognostic signature based on different expression of CRFGs in KIRC. All raw data of this study were extracted from public TCGA datasets. Cuproptosis and Ferroptosis genes were collected from the previous research. Finally, a total of 36 significantly different CRFGs were identified from TCGA-KIRC cohort. Six-gene signature (TRIB3, SLC2A3, PML, CD44, CDKN2A and MIOX) was identified by LASSO Cox regression based on the significantly different CRFGs. The CRFGs signature was correlated with worse overall survival and the AUC was 0.750. Functional enrichment indicated that CRFGs were mainly enriched in metabolism, drug resistance, tumor immunity pathways. Besides, the IC50 and immune checkpoint differentially expressed between different groups. The proposed 6-CRFGs signature is a promising biomarker to predict clinical outcomes and therapeutic responses for KIRC patient.
引用
收藏
页数：11
相关论文
共 56 条
[21]   Copper-induced cell death Excess copper causes mitochondrial protein aggregation and triggers a distinct form of cell death [J].
Kahison, Martha A. ;
Dixon, Scott J. .
SCIENCE, 2022, 375 (6586) :1231-1232
[22]   IHD from copper deficiency: a unified theory [J].
Klevay, Leslie M. .
NUTRITION RESEARCH REVIEWS, 2016, 29 (02) :172-179
[23]   Systemic Treatment of Metastatic Clear Cell Renal Cell Carcinoma in 2018: Current Paradigms, Use of Immunotherapy, and Future Directions [J].
Lalani, Aly-Khan A. ;
McGregor, Bradley A. ;
Albiges, Laurence ;
Choueiri, Toni K. ;
Motzer, Robert ;
Powles, Thomas ;
Wood, Christopher ;
Bex, Axel .
EUROPEAN UROLOGY, 2019, 75 (01) :100-110
[24]   The Role of the Mammalian Copper Transporter 1 in the Cellular Accumulation of Platinum-Based Drugs [J].
Larson, Christopher A. ;
Blair, Brian G. ;
Safaei, Roohangiz ;
Howell, Stephen B. .
MOLECULAR PHARMACOLOGY, 2009, 75 (02) :324-330
[25]   Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice [J].
LaVaute, T ;
Smith, S ;
Cooperman, S ;
Iwai, K ;
Land, W ;
Meyron-Holtz, E ;
Drake, SK ;
Miller, G ;
Abu-Asab, M ;
Tsokos, M ;
Switzer, R ;
Grinberg, A ;
Love, P ;
Tresser, N ;
Rouault, TA .
NATURE GENETICS, 2001, 27 (02) :209-214
[26]   SCP Phosphatases Suppress Renal Cell Carcinoma by Stabilizing PML and Inhibiting mTOR/HIF Signaling [J].
Lin, Yu-Ching ;
Lu, Li-Ting ;
Chen, Hsin-Yi ;
Duan, Xueyan ;
Lin, Xia ;
Feng, Xin-Hua ;
Tang, Ming-Jer ;
Chen, Ruey-Hwa .
CANCER RESEARCH, 2014, 74 (23) :6935-6946
[27]   Role of TRIB3 in regulation of insulin sensitivity and nutrient metabolism during short-term fasting and nutrient excess [J].
Liu, Jiarong ;
Zhang, Wei ;
Chuang, Gin C. ;
Hill, Helliner S. ;
Tian, Ling ;
Fu, Yuchang ;
Moellering, Douglas R. ;
Garvey, W. Timothy .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2012, 303 (07) :E908-E916
[28]   Development and validation of cuproptosis-related gene signature in the prognostic prediction of liver cancer [J].
Liu, Yanqing ;
Liu, Yang ;
Ye, Shujun ;
Feng, Huijin ;
Ma, Lianjun .
FRONTIERS IN ONCOLOGY, 2022, 12
[29]   Iron and cancer: recent insights [J].
Manz, David H. ;
Blanchette, Nicole L. ;
Paul, Bibbin T. ;
Torti, Frank M. ;
Torti, Suzy V. .
COOLEY'S ANEMIA, 2016, 1368 :149-161
[30]   Tumor-infiltrating CD8+ T cells recognize a heterogeneously expressed functional neoantigen in clear cell renal cell carcinoma [J].
Matsuki, Masahiro ;
Hirohashi, Yoshihiko ;
Nakatsugawa, Munehide ;
Murai, Aiko ;
Kubo, Terufumi ;
Hashimoto, Shinichi ;
Tokita, Serina ;
Murata, Kenji ;
Kanaseki, Takayuki ;
Tsukahara, Tomohide ;
Nishida, Sachiyo ;
Tanaka, Toshiaki ;
Kitamura, Hiroshi ;
Masumori, Naoya ;
Torigoe, Toshihiko .
CANCER IMMUNOLOGY IMMUNOTHERAPY, 2022, 71 (04) :905-918
123456