NAD+ metabolism-based immunoregulation and therapeutic potential

被引：12
作者：
Fang, Jiankai [1 ]
Chen, Wangwang [2 ]
Hou, Pengbo [1 ,3 ]
Liu, Zhanhong [1 ,3 ]
Zuo, Muqiu [1 ]
Liu, Shisong [1 ]
Feng, Chao [1 ,3 ]
Han, Yuyi [1 ,3 ]
Li, Peishan [1 ]
Shi, Yufang [1 ,4 ]
Shao, Changshun [1 ]
机构：
[1] Soochow Univ, Suzhou Med Coll, State Key Lab Radiat Med & Protect, Inst Translat Med,Affiliated Hosp 1, Suzhou, Jiangsu, Peoples R China
[2] Soochow Univ, Lab Anim Ctr, Suzhou Med Coll, Suzhou, Jiangsu, Peoples R China
[3] Univ Roma Tor Vergata, Dept Expt Med & Biochem Sci, Rome, Italy
[4] Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Shanghai Inst Biol Sci, Shanghai, Peoples R China
来源：
CELL AND BIOSCIENCE | 2023年 / 13卷 / 01期
基金：
国家重点研发计划; 中国国家自然科学基金;
关键词：
Nicotinamide adenine dinucleotide (NAD(+)); Immunoregulation; Metabolic homeostasis; Plasticity; Disease therapy; NICOTINAMIDE ADENINE-DINUCLEOTIDE; T-CELL APOPTOSIS; POLY(ADP-RIBOSE) POLYMERASES; MITOCHONDRIAL DYSFUNCTION; EXTRACELLULAR NAD(+); BOOSTING MOLECULES; PROTEIN SIR2; IN-VIVO; SIRTUINS; CD38;
D O I：
10.1186/s13578-023-01031-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nicotinamide adenine dinucleotide (NAD(+)) is a critical metabolite that acts as a cofactor in energy metabolism, and serves as a cosubstrate for non-redox NAD(+)-dependent enzymes, including sirtuins, CD38 and poly(ADP-ribose) polymerases. NAD(+) metabolism can regulate functionality attributes of innate and adaptive immune cells and contribute to inflammatory responses. Thus, the manipulation of NAD(+) bioavailability can reshape the courses of immunological diseases. Here, we review the basics of NAD(+) biochemistry and its roles in the immune response, and discuss current challenges and the future translational potential of NAD(+) research in the development of therapeutics for inflammatory diseases, such as COVID-19.
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页数：15
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