Bifidobacterium lactis IDCC 4301 Exerts Anti-Obesity Effects in High-Fat Diet-Fed Mice Model by Regulating Lipid Metabolism

被引:21
作者
Ban, O-Hyun [1 ,2 ]
Lee, Minjee [1 ]
Bang, Won Yeong [1 ]
Nam, Eoun Ho [3 ]
Jeon, Hyeon Ji [2 ]
Shin, Minhye [3 ]
Yang, Jungwoo [1 ]
Jung, Young Hoon [2 ]
机构
[1] Ildong Biosci, Pyeongtaek Si 17957, Gyeonggi Do, South Korea
[2] Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea
[3] Inha Univ, Coll Med, Dept Microbiol, Incheon 22212, South Korea
基金
新加坡国家研究基金会; 欧洲研究理事会;
关键词
anti-obesity; Bifidobacterium lactis; lactic acid bacteria; metabolomic analysis; probiotics; GUT MICROBIOME; OBESE; ADIPOGENESIS; ASSOCIATION; EXPRESSION; LEPTIN; GAMMA; OB;
D O I
10.1002/mnfr.202200385
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
ScopeChronic hypernutrition promotes lipid accumulation in the body and excessive lipid accumulation leads to obesity. An increase in the number and size of adipocytes, a characteristic of obesity is closely associated with adipose dysfunction. Recent in vitro and in vivo studies have shown that probiotics may prevent this dysfunction by regulating lipid metabolism. However, the mechanisms of action of probiotics in obesity are not fully understood and their usage for treating obesity remains limited. Methods and resultsBifidobacterium lactis IDCC 4301 is selected for its anti-obesity potential after evaluating inhibitory activity of pancreatic lipase and cholesterol reducing activity. Next, this study investigates the roles of B. lactis IDCC 4301 on lipid metabolism in 3T3-L1 preadipocytes and high-fat diet (HFD)-fed mice. B. lactis IDCC 4301 inhibits cell differentiation and lipid accumulation by suppressing the expression of adipogenic enzymes in 3T3-L1 cells. Moreover, the administration of B. lactis IDCC 4301 decreases body and adipose tissue weight, improves serum lipid levels, and downregulates adipogenic mRNA expression in HFD-fed mice. Additionally, metabolomic analysis suggests that 2-ketobutyrate should be a possible target compound against obesity. ConclusionsB. lactis IDCC 4301 may be used as an alternative treatment for obesity.
引用
收藏
页数:10
相关论文
共 50 条
[1]   Emerging Perspectives on Essential Amino Acid Metabolism in Obesity and the Insulin-Resistant State [J].
Adams, Sean H. .
ADVANCES IN NUTRITION, 2011, 2 (06) :445-456
[2]   Antiobesity and lipid-lowering effects of Bifidobacterium spp. in high fat diet-induced obese rats [J].
An, Hyang Mi ;
Park, Shin Young ;
Lee, Do Kyung ;
Kim, Jung Rae ;
Cha, Min Kyeong ;
Lee, Si Won ;
Lim, Hyung Taeck ;
Kim, Kyung Jae ;
Ha, Nam Joo .
LIPIDS IN HEALTH AND DISEASE, 2011, 10
[3]   Obesity: global epidemiology and pathogenesis [J].
Blueher, Matthias .
NATURE REVIEWS ENDOCRINOLOGY, 2019, 15 (05) :288-298
[4]   Association of overweight with increased risk of coronary heart disease partly independent of blood pressure and cholesterol levels - A meta-analysis of 21 cohort studies including more than 300,000 persons [J].
Bogers, Rik P. ;
Bemelmans, Wanda J. E. ;
Hoogenveen, Rudolf T. ;
Boshuizen, Hendriek C. ;
Woodward, Mark ;
Knekt, Paul ;
van Dam, Rob M. ;
Hu, Frank B. ;
Visscher, Tommy L. S. ;
Menotti, Alessandro ;
Thorpe, Roland J., Jr. ;
Jamrozik, Konrad ;
Calling, Susanna ;
Strand, Bjorn Heine ;
Shipley, Martin J. .
ARCHIVES OF INTERNAL MEDICINE, 2007, 167 (16) :1720-1728
[5]   Cholesterol-lowering probiotics: in vitro selection and in vivo testing of bifidobacteria [J].
Bordoni, Alessandra ;
Amaretti, Alberto ;
Leonardi, Alan ;
Boschetti, Elisa ;
Danesi, Francesca ;
Matteuzzi, Diego ;
Roncaglia, Lucia ;
Raimondi, Stefano ;
Rossi, Maddalena .
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2013, 97 (18) :8273-8281
[6]   RESISTANCE OF CERTAIN LONG-CHAIN POLUUNSATURATED FATTY ACIDS OF MARINE OILS TO PANCREATIC LIPASE HYDROLYSIS [J].
BOTTINO, NR ;
VANDENBURG, GA ;
REISER, R .
LIPIDS, 1967, 2 (06) :489-+
[7]   Exploring the Bacterial Impact on Cholesterol Cycle: A Numerical Study [J].
Bourgin, Melanie ;
Labarthe, Simon ;
Kriaa, Aicha ;
Lhomme, Marie ;
Gerard, Philippe ;
Lesnik, Philippe ;
Laroche, Beatrice ;
Maguin, Emmanuelle ;
Rhimi, Moez .
FRONTIERS IN MICROBIOLOGY, 2020, 11
[8]   The Effect of 2-Ketobutyrate on Mitochondrial Substrate-Level Phosphorylation [J].
Bui, David ;
Ravasz, Dora ;
Chinopoulos, Christos .
NEUROCHEMICAL RESEARCH, 2019, 44 (10) :2301-2306
[9]   Direct medical costs of obesity in the United States and the most populous states [J].
Cawley, John ;
Biener, Adam ;
Meyerhoefer, Chad ;
Ding, Yuchen ;
Zvenyach, Tracy ;
Smolarz, B. Gabriel ;
Ramasamy, Abhilasha .
JOURNAL OF MANAGED CARE & SPECIALTY PHARMACY, 2021, 27 (03) :354-366
[10]   Adipocyte browning and resistance to obesity in mice is induced by expression of ATF3 [J].
Cheng, Ching-Feng ;
Ku, Hui-Chen ;
Cheng, Jing-Jy ;
Chao, Shi-Wei ;
Li, Hsiao-Fen ;
Lai, Pei-Fang ;
Chang, Che-Chang ;
Don, Ming-Jaw ;
Chen, Hsi-Hsien ;
Lin, Heng .
COMMUNICATIONS BIOLOGY, 2019, 2 (1)