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Bifidobacterium lactis IDCC 4301 Exerts Anti-Obesity Effects in High-Fat Diet-Fed Mice Model by Regulating Lipid Metabolism
被引:21
作者:

Ban, O-Hyun
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Ildong Biosci, Pyeongtaek Si 17957, Gyeonggi Do, South Korea
Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea Ildong Biosci, Pyeongtaek Si 17957, Gyeonggi Do, South Korea

Lee, Minjee
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Ildong Biosci, Pyeongtaek Si 17957, Gyeonggi Do, South Korea Ildong Biosci, Pyeongtaek Si 17957, Gyeonggi Do, South Korea

Bang, Won Yeong
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Ildong Biosci, Pyeongtaek Si 17957, Gyeonggi Do, South Korea Ildong Biosci, Pyeongtaek Si 17957, Gyeonggi Do, South Korea

Nam, Eoun Ho
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Inha Univ, Coll Med, Dept Microbiol, Incheon 22212, South Korea Ildong Biosci, Pyeongtaek Si 17957, Gyeonggi Do, South Korea

Jeon, Hyeon Ji
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Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea Ildong Biosci, Pyeongtaek Si 17957, Gyeonggi Do, South Korea

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Yang, Jungwoo
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Ildong Biosci, Pyeongtaek Si 17957, Gyeonggi Do, South Korea Ildong Biosci, Pyeongtaek Si 17957, Gyeonggi Do, South Korea

Jung, Young Hoon
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机构:
Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea Ildong Biosci, Pyeongtaek Si 17957, Gyeonggi Do, South Korea
机构:
[1] Ildong Biosci, Pyeongtaek Si 17957, Gyeonggi Do, South Korea
[2] Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea
[3] Inha Univ, Coll Med, Dept Microbiol, Incheon 22212, South Korea
基金:
新加坡国家研究基金会;
欧洲研究理事会;
关键词:
anti-obesity;
Bifidobacterium lactis;
lactic acid bacteria;
metabolomic analysis;
probiotics;
GUT MICROBIOME;
OBESE;
ADIPOGENESIS;
ASSOCIATION;
EXPRESSION;
LEPTIN;
GAMMA;
OB;
D O I:
10.1002/mnfr.202200385
中图分类号:
TS2 [食品工业];
学科分类号:
0832 ;
摘要:
ScopeChronic hypernutrition promotes lipid accumulation in the body and excessive lipid accumulation leads to obesity. An increase in the number and size of adipocytes, a characteristic of obesity is closely associated with adipose dysfunction. Recent in vitro and in vivo studies have shown that probiotics may prevent this dysfunction by regulating lipid metabolism. However, the mechanisms of action of probiotics in obesity are not fully understood and their usage for treating obesity remains limited. Methods and resultsBifidobacterium lactis IDCC 4301 is selected for its anti-obesity potential after evaluating inhibitory activity of pancreatic lipase and cholesterol reducing activity. Next, this study investigates the roles of B. lactis IDCC 4301 on lipid metabolism in 3T3-L1 preadipocytes and high-fat diet (HFD)-fed mice. B. lactis IDCC 4301 inhibits cell differentiation and lipid accumulation by suppressing the expression of adipogenic enzymes in 3T3-L1 cells. Moreover, the administration of B. lactis IDCC 4301 decreases body and adipose tissue weight, improves serum lipid levels, and downregulates adipogenic mRNA expression in HFD-fed mice. Additionally, metabolomic analysis suggests that 2-ketobutyrate should be a possible target compound against obesity. ConclusionsB. lactis IDCC 4301 may be used as an alternative treatment for obesity.
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[1]
Emerging Perspectives on Essential Amino Acid Metabolism in Obesity and the Insulin-Resistant State
[J].
Adams, Sean H.
.
ADVANCES IN NUTRITION,
2011, 2 (06)
:445-456

Adams, Sean H.
论文数: 0 引用数: 0
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Univ Calif Davis, Obes & Metab Res Unit, USDA ARS, Western Human Nutr Res Ctr, Davis, CA 95616 USA
Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA Univ Calif Davis, Obes & Metab Res Unit, USDA ARS, Western Human Nutr Res Ctr, Davis, CA 95616 USA
[2]
Antiobesity and lipid-lowering effects of Bifidobacterium spp. in high fat diet-induced obese rats
[J].
An, Hyang Mi
;
Park, Shin Young
;
Lee, Do Kyung
;
Kim, Jung Rae
;
Cha, Min Kyeong
;
Lee, Si Won
;
Lim, Hyung Taeck
;
Kim, Kyung Jae
;
Ha, Nam Joo
.
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2011, 10

An, Hyang Mi
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Sahmyook Univ, Coll Pharm, Seoul 139742, South Korea Sahmyook Univ, Coll Pharm, Seoul 139742, South Korea

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Sahmyook Univ, Coll Pharm, Seoul 139742, South Korea Sahmyook Univ, Coll Pharm, Seoul 139742, South Korea

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Sahmyook Univ, Coll Pharm, Seoul 139742, South Korea Sahmyook Univ, Coll Pharm, Seoul 139742, South Korea
[3]
Obesity: global epidemiology and pathogenesis
[J].
Blueher, Matthias
.
NATURE REVIEWS ENDOCRINOLOGY,
2019, 15 (05)
:288-298

Blueher, Matthias
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Leipzig, Dept Med, Leipzig, Germany Univ Leipzig, Dept Med, Leipzig, Germany
[4]
Association of overweight with increased risk of coronary heart disease partly independent of blood pressure and cholesterol levels - A meta-analysis of 21 cohort studies including more than 300,000 persons
[J].
Bogers, Rik P.
;
Bemelmans, Wanda J. E.
;
Hoogenveen, Rudolf T.
;
Boshuizen, Hendriek C.
;
Woodward, Mark
;
Knekt, Paul
;
van Dam, Rob M.
;
Hu, Frank B.
;
Visscher, Tommy L. S.
;
Menotti, Alessandro
;
Thorpe, Roland J., Jr.
;
Jamrozik, Konrad
;
Calling, Susanna
;
Strand, Bjorn Heine
;
Shipley, Martin J.
.
ARCHIVES OF INTERNAL MEDICINE,
2007, 167 (16)
:1720-1728

Bogers, Rik P.
论文数: 0 引用数: 0
h-index: 0
机构: Natl Inst Publ Hlth & Environm, Ctr Prevent & Hlth Serv Res, NL-3720 BA Bilthoven, Netherlands

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Woodward, Mark
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Hu, Frank B.
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[5]
Cholesterol-lowering probiotics: in vitro selection and in vivo testing of bifidobacteria
[J].
Bordoni, Alessandra
;
Amaretti, Alberto
;
Leonardi, Alan
;
Boschetti, Elisa
;
Danesi, Francesca
;
Matteuzzi, Diego
;
Roncaglia, Lucia
;
Raimondi, Stefano
;
Rossi, Maddalena
.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,
2013, 97 (18)
:8273-8281

Bordoni, Alessandra
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Amaretti, Alberto
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Leonardi, Alan
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Modena & Reggio Emilia, Dept Life Sci, I-41100 Modena, Italy Univ Bologna, Dept Agrofood Sci & Technol, I-47521 Cesena, Italy

Boschetti, Elisa
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bologna, Dept Biomed & Neuromotor Sci, I-40126 Bologna, Italy Univ Bologna, Dept Agrofood Sci & Technol, I-47521 Cesena, Italy

Danesi, Francesca
论文数: 0 引用数: 0
h-index: 0
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Univ Bologna, Dept Agrofood Sci & Technol, I-47521 Cesena, Italy Univ Bologna, Dept Agrofood Sci & Technol, I-47521 Cesena, Italy

Matteuzzi, Diego
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bologna, Dept Pharmaceut Sci, I-40126 Bologna, Italy Univ Bologna, Dept Agrofood Sci & Technol, I-47521 Cesena, Italy

Roncaglia, Lucia
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Modena & Reggio Emilia, Dept Life Sci, I-41100 Modena, Italy Univ Bologna, Dept Agrofood Sci & Technol, I-47521 Cesena, Italy

Raimondi, Stefano
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Modena & Reggio Emilia, Dept Life Sci, I-41100 Modena, Italy Univ Bologna, Dept Agrofood Sci & Technol, I-47521 Cesena, Italy

Rossi, Maddalena
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Modena & Reggio Emilia, Dept Life Sci, I-41100 Modena, Italy Univ Bologna, Dept Agrofood Sci & Technol, I-47521 Cesena, Italy
[6]
RESISTANCE OF CERTAIN LONG-CHAIN POLUUNSATURATED FATTY ACIDS OF MARINE OILS TO PANCREATIC LIPASE HYDROLYSIS
[J].
BOTTINO, NR
;
VANDENBURG, GA
;
REISER, R
.
LIPIDS,
1967, 2 (06)
:489-+

BOTTINO, NR
论文数: 0 引用数: 0
h-index: 0

VANDENBURG, GA
论文数: 0 引用数: 0
h-index: 0

REISER, R
论文数: 0 引用数: 0
h-index: 0
[7]
Exploring the Bacterial Impact on Cholesterol Cycle: A Numerical Study
[J].
Bourgin, Melanie
;
Labarthe, Simon
;
Kriaa, Aicha
;
Lhomme, Marie
;
Gerard, Philippe
;
Lesnik, Philippe
;
Laroche, Beatrice
;
Maguin, Emmanuelle
;
Rhimi, Moez
.
FRONTIERS IN MICROBIOLOGY,
2020, 11

Bourgin, Melanie
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris Saclay, Micalis Inst, AgroParisTech, INRAE, Jouy En Josas, France Univ Paris Saclay, Micalis Inst, AgroParisTech, INRAE, Jouy En Josas, France

论文数: 引用数:
h-index:
机构:

Kriaa, Aicha
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris Saclay, Micalis Inst, AgroParisTech, INRAE, Jouy En Josas, France Univ Paris Saclay, Micalis Inst, AgroParisTech, INRAE, Jouy En Josas, France

Lhomme, Marie
论文数: 0 引用数: 0
h-index: 0
机构:
Sorbonne Univ, Hop Pitie Salpetriere, INSERM, UMRS 1166, Paris, France
Inst Cardiometab & Nutr, ICANalyt, ANR 10 IAHU 05, IHU ICAN, Paris, France Univ Paris Saclay, Micalis Inst, AgroParisTech, INRAE, Jouy En Josas, France

Gerard, Philippe
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris Saclay, Micalis Inst, AgroParisTech, INRAE, Jouy En Josas, France Univ Paris Saclay, Micalis Inst, AgroParisTech, INRAE, Jouy En Josas, France

Lesnik, Philippe
论文数: 0 引用数: 0
h-index: 0
机构:
Sorbonne Univ, Hop Pitie Salpetriere, INSERM, UMRS 1166, Paris, France Univ Paris Saclay, Micalis Inst, AgroParisTech, INRAE, Jouy En Josas, France

Laroche, Beatrice
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris Saclay, MaIAGE, INRAE, Jouy En Josas, France Univ Paris Saclay, Micalis Inst, AgroParisTech, INRAE, Jouy En Josas, France

论文数: 引用数:
h-index:
机构:

Rhimi, Moez
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris Saclay, Micalis Inst, AgroParisTech, INRAE, Jouy En Josas, France Univ Paris Saclay, Micalis Inst, AgroParisTech, INRAE, Jouy En Josas, France
[8]
The Effect of 2-Ketobutyrate on Mitochondrial Substrate-Level Phosphorylation
[J].
Bui, David
;
Ravasz, Dora
;
Chinopoulos, Christos
.
NEUROCHEMICAL RESEARCH,
2019, 44 (10)
:2301-2306

论文数: 引用数:
h-index:
机构:

Ravasz, Dora
论文数: 0 引用数: 0
h-index: 0
机构:
Semmelweis Univ, Dept Med Biochem, Tuzolto St 37-47, H-1094 Budapest, Hungary Semmelweis Univ, Dept Med Biochem, Tuzolto St 37-47, H-1094 Budapest, Hungary

论文数: 引用数:
h-index:
机构:
[9]
Direct medical costs of obesity in the United States and the most populous states
[J].
Cawley, John
;
Biener, Adam
;
Meyerhoefer, Chad
;
Ding, Yuchen
;
Zvenyach, Tracy
;
Smolarz, B. Gabriel
;
Ramasamy, Abhilasha
.
JOURNAL OF MANAGED CARE & SPECIALTY PHARMACY,
2021, 27 (03)
:354-366

Cawley, John
论文数: 0 引用数: 0
h-index: 0
机构:
Cornell Univ, Dept Policy Anal & Management, Ithaca, NY 14850 USA
Cornell Univ, Dept Econ, Ithaca, NY 14850 USA Cornell Univ, Dept Policy Anal & Management, Ithaca, NY 14850 USA

Biener, Adam
论文数: 0 引用数: 0
h-index: 0
机构:
Lafayette Coll, Dept Econ, Easton, PA 18042 USA Cornell Univ, Dept Policy Anal & Management, Ithaca, NY 14850 USA

Meyerhoefer, Chad
论文数: 0 引用数: 0
h-index: 0
机构:
Lehigh Univ, Coll Business, Bethlehem, PA 18015 USA Cornell Univ, Dept Policy Anal & Management, Ithaca, NY 14850 USA

Ding, Yuchen
论文数: 0 引用数: 0
h-index: 0
机构:
Bluebird Bio, Cambridge, MA USA Cornell Univ, Dept Policy Anal & Management, Ithaca, NY 14850 USA

Zvenyach, Tracy
论文数: 0 引用数: 0
h-index: 0
机构:
Healthcare & Obes Publ Policy, Madison, WI USA Cornell Univ, Dept Policy Anal & Management, Ithaca, NY 14850 USA

Smolarz, B. Gabriel
论文数: 0 引用数: 0
h-index: 0
机构:
Novo Nordisk, Plainsboro, NJ USA Cornell Univ, Dept Policy Anal & Management, Ithaca, NY 14850 USA

Ramasamy, Abhilasha
论文数: 0 引用数: 0
h-index: 0
机构:
Novo Nordisk, Plainsboro, NJ USA Cornell Univ, Dept Policy Anal & Management, Ithaca, NY 14850 USA
[10]
Adipocyte browning and resistance to obesity in mice is induced by expression of ATF3
[J].
Cheng, Ching-Feng
;
Ku, Hui-Chen
;
Cheng, Jing-Jy
;
Chao, Shi-Wei
;
Li, Hsiao-Fen
;
Lai, Pei-Fang
;
Chang, Che-Chang
;
Don, Ming-Jaw
;
Chen, Hsi-Hsien
;
Lin, Heng
.
COMMUNICATIONS BIOLOGY,
2019, 2 (1)

论文数: 引用数:
h-index:
机构:

Ku, Hui-Chen
论文数: 0 引用数: 0
h-index: 0
机构:
Buddhist Tzu Chi Med Fdn, Taipei Tzu Chi Hosp, Dept Pediat, Taipei, Taiwan
Taipei Med Univ, PhD Program Biotechnol Res & Dev, Taipei, Taiwan
Taipei Med Univ, Coll Med, Sch Med, Dept Physiol, Taipei, Taiwan Buddhist Tzu Chi Med Fdn, Taipei Tzu Chi Hosp, Dept Pediat, Taipei, Taiwan

Cheng, Jing-Jy
论文数: 0 引用数: 0
h-index: 0
机构:
Taipei Med Univ, PhD Program Clin Drug Discovery Bot Herbs, Taipei, Taiwan
Natl Res Inst Chinese Med, Taipei, Taiwan Buddhist Tzu Chi Med Fdn, Taipei Tzu Chi Hosp, Dept Pediat, Taipei, Taiwan

Chao, Shi-Wei
论文数: 0 引用数: 0
h-index: 0
机构:
Taipei Med Univ, PhD Program Biotechnol Res & Dev, Taipei, Taiwan
Taipei Med Univ, Coll Med, Sch Med, Dept Physiol, Taipei, Taiwan Buddhist Tzu Chi Med Fdn, Taipei Tzu Chi Hosp, Dept Pediat, Taipei, Taiwan

Li, Hsiao-Fen
论文数: 0 引用数: 0
h-index: 0
机构:
Taipei Med Univ, PhD Program Biotechnol Res & Dev, Taipei, Taiwan Buddhist Tzu Chi Med Fdn, Taipei Tzu Chi Hosp, Dept Pediat, Taipei, Taiwan

Lai, Pei-Fang
论文数: 0 引用数: 0
h-index: 0
机构:
Buddhist Tzu Chi Gen Hosp, Dept Emergency Med, Hualien, Taiwan Buddhist Tzu Chi Med Fdn, Taipei Tzu Chi Hosp, Dept Pediat, Taipei, Taiwan

Chang, Che-Chang
论文数: 0 引用数: 0
h-index: 0
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Taipei Med Univ, PhD Program Biotechnol Res & Dev, Taipei, Taiwan Buddhist Tzu Chi Med Fdn, Taipei Tzu Chi Hosp, Dept Pediat, Taipei, Taiwan

Don, Ming-Jaw
论文数: 0 引用数: 0
h-index: 0
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Natl Res Inst Chinese Med, Taipei, Taiwan Buddhist Tzu Chi Med Fdn, Taipei Tzu Chi Hosp, Dept Pediat, Taipei, Taiwan

Chen, Hsi-Hsien
论文数: 0 引用数: 0
h-index: 0
机构:
Taipei Med Univ, Coll Med, Sch Med, Dept Internal Med,Div Nephrol, Taipei, Taiwan
Taipei Med Univ Hosp, Dept Internal Med, Div Nephrol, Taipei, Taiwan Buddhist Tzu Chi Med Fdn, Taipei Tzu Chi Hosp, Dept Pediat, Taipei, Taiwan

Lin, Heng
论文数: 0 引用数: 0
h-index: 0
机构:
Taipei Med Univ, PhD Program Biotechnol Res & Dev, Taipei, Taiwan
Taipei Med Univ, Coll Med, Sch Med, Dept Physiol, Taipei, Taiwan Buddhist Tzu Chi Med Fdn, Taipei Tzu Chi Hosp, Dept Pediat, Taipei, Taiwan