Lipid Droplets in Virus Replication

被引：6

作者：

Herker, Eva ^{[1
]}

机构：

[1] Philipps Univ Marburg, Inst Virol, Marburg, Germany

来源：

FEBS LETTERS | 2024年 / 598卷 / 10期

关键词：

assembly; lipid droplet; metabolism; replication organelles; viruses; HEPATITIS-C VIRUS; FATTY-ACID SYNTHASE; CORE PROTEIN; INFECTION; LOCALIZES; RAB18; SITES; ALPHA; CYCLE;

D O I：

10.1002/1873-3468.14819

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Intracellular pathogens rely on host metabolic networks for multiplication. Enveloped viruses need lipids for formation of the viral envelope and positive sense RNA viruses that replicate in membranous inclusions require lipids for formation of the replication compartments. In addition, all intracellular pathogens need energy for their replicative cycle. As triglycerides in lipid droplets are the main energy storage unit of cells and major source of membrane lipids, it is not surprising that viruses have evolved various strategies to exploit different aspects of lipid droplet biology.

引用

页码：1299 / 1300

页数：2

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