Recent Progress Toward Total Syntheses of Iheyamines A and B

被引：0

作者：

Kim, Tae Lyn ^{[1
]}

Jeon, Jiye ^{[1
]}

Lee, Yong Ho ^{[1
]}

Cheon, Cheol-Hong ^{[1
]}

机构：

[1] Korea Univ, Dept Chem, 145 Anam ro, Seoul 02841, South Korea

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 13卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

iheyamines A and B; total synthesis; azepinobisindoles; alkaloids; natural products; CATALYZED ALLYLIC ALKYLATION; INDOLE-3-ACETIC-ACID DERIVATIVES; SKELETON;

D O I：

10.1002/ajoc.202300513

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This perspective article describes the recent progress in the total syntheses of iheyamines A and B. Since iheyamine A possesses a highly unique unsymmetrical azepino-2,2'-bisindole scaffold, novel strategies to construct the basic scaffold have been developed, and unique total syntheses have been reported based on these strategies. In addition, because iheyamine B bears vicinal 2-oxopropyl moieties with a trans-configuration in the azepine scaffold of iheyamine A, the first asymmetric total synthesis of iheyamine B took a substantially longer time than iheyamine A to complete. Due to the unusual structure of iheyamine B and some discrepancies in the experimental data between the isolated and synthesized iheyamine B, some controversial issues regarding whether iheyamine B is a natural product or an artifact have been raised and will be discussed. This perspective provides an overview of the recent progress in the total synthesis of iheyamines A and B, including the development of novel strategies to access the unique structural features of these natural products. In addition, controversial issues regarding whether iheyamine B is a natural product or an artifact are discussed.image

引用

页数：11

共 31 条

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