The comorbidity and co-medication profile of patients with progressive supranuclear palsy

被引：6

作者：

Greten, Stephan ^{[1
]}

Wegner, Florian ^{[1
]}

Jensen, Ida ^{[1
]}

Krey, Lea ^{[1
]}

Rogozinski, Sophia ^{[1
]}

Fehring, Meret ^{[1
]}

Heine, Johanne ^{[1
]}

Doll-Lee, Johanna ^{[1
]}

Poetter-Nerger, Monika ^{[2
]}

Zeitzschel, Molly ^{[2
]}

Hagena, Keno ^{[2
]}

Pedrosa, David J. ^{[3
]}

Eggers, Carsten ^{[4
]}

Buerk, Katrin ^{[5
]}

Trenkwalder, Claudia ^{[6
]}

Claus, Inga ^{[7
]}

Warnecke, Tobias ^{[8
]}

Suess, Patrick ^{[9
,10
]}

Winkler, Juergen ^{[9
,10
]}

Gruber, Doreen ^{[11
]}

Gandor, Florin ^{[11
]}

Berg, Daniela ^{[12
]}

Paschen, Steffen ^{[12
]}

Classen, Joseph ^{[13
]}

Pinkhardt, Elmar H. ^{[14
]}

Kassubek, Jan ^{[14
,15
]}

Jost, Wolfgang H. ^{[16
]}

Toenges, Lars ^{[17
,18
]}

Kuehn, Andrea A. ^{[19
,20
]}

Schwarz, Johannes ^{[21
]}

Peters, Oliver ^{[20
,22
]}

Dashti, Eman ^{[23
]}

Priller, Josef ^{[20
,24
,25
]}

Spruth, Eike J. ^{[20
,24
]}

Krause, Patricia ^{[20
]}

Spottke, Annika ^{[26
,27
]}

Schneider, Anja ^{[26
,28
]}

Beyle, Aline ^{[26
,27
]}

Kimmich, Okka ^{[26
,27
]}

Donix, Markus ^{[29
,30
]}

Haussmann, Robert ^{[30
]}

Brandt, Moritz ^{[29
,31
]}

Dinter, Elisabeth ^{[29
,31
]}

Wiltfang, Jens ^{[32
,33
,34
]}

Schott, Bjoern H. ^{[32
,33
]}

Zerr, Inga ^{[32
,35
]}

Baehr, Mathias ^{[32
,35
,36
]}

Buerger, Katharina ^{[37
,38
]}

Janowitz, Daniel ^{[37
,38
]}

Perneczky, Robert ^{[37
,39
,40
,41
]}

机构：

[1] Hannover Med Sch, Dept Neurol, Carl Neuberg Str 1, D-30625 Hannover, Germany

[2] Univ Med Ctr Hamburg Eppendorf, Dept Neurol, Martinistr 52, D-20246 Hamburg, Germany

[3] Univ Hosp Giessen & Marburg, Dept Neurol, Giessen, Germany

[4] Knappsxhaftskrankenhaus Bottrop, Dept Neurol, Osterfelder Str 157, DE-46242 Bottrop, Germany

[5] Kliniken Schmieder Stuttgart Gerlingen, Solitudestr 20, D-70839 Gerlingen, Germany

[6] Paracelsus Elena Klin, Kliniksr 16, D-34128 Kassel, Germany

[7] Univ Hosp Muenster, Dept Neurol, Inst Translat Neurol, Albert Schweitzer Campus 1 A, D-48149 Munster, Germany

[8] WWU Muenster, Dept Neurol & Neurorehabil, Klinikum Osnabrueck, Acad Teaching Hosp, Osnabruck, Germany

[9] Friedrich Alexander Univ Erlangen Nurnberg, Univ Hosp Erlangen, Dept Mol Neurol, D-91054 Erlangen, Germany

[10] Friedrich Alexander Univ Erlangen Nurnberg,, Univ Hosp Erlangen, Ctr Rare Dis Erlangen ZSEER, D-91054 Erlangen, Germany

[11] Movement Disorders Hosp, Str Nach Fichtenwalde 16, D-14547 Beelitz, Germany

[12] Univ Kiel, D-24118 Kiel, Germany

[13] Univ Leipzig, Med Ctr, Dept Diagnost & Intervent Radiol, Leipzig, Germany

[14] Univ Ulm, Dept Neurol, Oberer Eselsberg 45, D-89081 Ulm, Germany

[15] German Ctr Neurodegenerat Dis DZNE, D-89081 Ulm, Germany

[16] Parkinson Klin Ortenau, Kreuzbergstr 12, D-77709 Wolfach, Germany

[17] Ruhr Univ Bochum, St Josef Hosp, Dept Neurol, Gudrunstr 56, D-44791 Bochum, Germany

[18] Ruhr Univ Bochum, Prot Res Unit Ruhr PURE, Neurodegenerat Res, D-44801 Bochum, Germany

[19] Charite Univ Med Berlin, Dept Neurol, Movement Disorder & Neuromodulat Unit, Charitepl 1, D-10117 Berlin, Germany

[20] German Ctr Neurodegenerat Dis DZNE, Charitepl 1, D-10117 Berlin, Germany

[21] Kliniken Kreis Muehldorf Inn, Dept Surg, Krankenhausstr 1, D-84453 Muehldorf, Germany

[22] Berlin Inst Hlth, Dept Neuroradiol,Charite, Universitatsmedizin Berlin,Univers Berlin, Chariteplatz 1, DE-10117 Berlin, Germany

[23] Berlin Inst Hlth, Dept Neurol, Charitepl 1, D-10117 Berlin, Germany

[24] Charite, Dept Psychiat & Psychotherapy, Charitepl 1, D-10117 Berlin, Germany

[25] Tech Univ Munich, Dept Psychiat & Psychotherapy, Klinikum Rechts Isar, Ismaninger Str 22, D-81675 Munich, Germany

[26] German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

[27] Univ Hosp Bonn, Dept Neurol, Venusberg Campus 1, D-53127 Bonn, Germany

[28] Univ Hosp Bonn, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany

[29] Helmholtz Assoc, German Ctr Neurodegenerat Dis DZNE, Tatzberg 41, D-01307 Dresden, Germany

[30] Tech Univ Dresden, Carl Gustav Carus Univ Hosp, Dept Psychiat & Psychotherapy, Fetscherstrasse 74, D-01307 Dresden, Germany

[31] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Neurol, Fetscherstr 74, D-01307 Dresden, Germany

[32] German Ctr Neurodegenerat Dis DZNE, Von Siebold Str 3a, D-37075 Gottingen, Germany

[33] Univ Gottingen, Univ Med Ctr, Dept Psychiat & Psychotherapy, von Siebold Str 5, D-37075 Gottingen, Germany

[34] Univ Aveiro, Inst Biomed iBiMED, Dept Med Sci, Neurosci & Signaling Grp, Aveiro, Portugal

[35] Georg August Univ, Univ Med Ctr, Dept Neuropathol, Gottingen, Germany

[36] Cluster Excellence 171 DFG Res Ctr 103 CNMPB, Nanoscale Microscopy & Mol Physiol Brain, Gottingen, Germany

[37] German Ctr Neurodegenerat Dis DZNE, Munich, Germany

[38] Munich Univ Hosp, Inst Stroke & Dementia Res, Feodor Lynen Str 17, D-81377 Munich, Germany

[39] Univ Munich, Dept Psychiat & Psychotherapy, Munich, Germany

[40] Munich Cluster Syst Neurol SyNergy, Munich, Germany

[41] Imperial Coll London, Sch Publ Hlth, Ageing Epidemiol Res Unit, London, England

[42] Ludwig Maximilians Univ Munchen, Univ Hosp Munich, Dept Neurol, Marchioninistr 15, D-81377 Munich, Germany

[43] German Ctr Neurodegenerat Dis DZNE, Leipziger Str 44, D-39120 Magdeburg, Germany

[44] Otto von Guericke Univ, Inst Cognit Neurol & Dementia Res, D-39120 Magdeburg, Germany

[45] Univ London Univ Coll, Inst Cognit Neurosci, Gower St, London WC1E 6BT, England

[46] Univ Hosp Magdeburg, Dept Radiol & Nucl Med, Leipziger Str 44, D-39120 Magdeburg, Germany

[47] German Ctr Neurodegenerat Dis DZNE, Gehlsheimer Str 20, D-18147 Rostock, Germany

[48] Rostock Univ, Med Ctr, Dept Anesthesiol & Intens Care Med, Schillingallee 35, D-18057 Rostock, Germany

[49] Univ Med Ctr Rostock, Dept Urol, Schillingallee 35, D-18057 Rostock, Germany

[50] German Ctr Neurodegenerat Dis DZNE, Tubingen, Germany

来源：

JOURNAL OF NEUROLOGY | 2024年 / 271卷 / 02期

关键词：

Progressive supranuclear palsy; Comorbidities; Polypharmacy; Drug-drug interactions; SUDDEN CARDIAC DEATH; PARKINSONS-DISEASE; OLDER-ADULTS; VENTRICULAR-ARRHYTHMIA; CLINICAL-DIAGNOSIS; ALZHEIMERS-DISEASE; DRUG INTERACTIONS; IN-VIVO; PREVALENCE; POLYPHARMACY;

D O I：

10.1007/s00415-023-12006-4

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

BackgroundProgressive supranuclear palsy (PSP) is usually diagnosed in elderly. Currently, little is known about comorbidities and the co-medication in these patients.ObjectivesTo explore the pattern of comorbidities and co-medication in PSP patients according to the known different phenotypes and in comparison with patients without neurodegenerative disease.MethodsCross-sectional data of PSP and patients without neurodegenerative diseases (non-ND) were collected from three German multicenter observational studies (DescribePSP, ProPSP and DANCER). The prevalence of comorbidities according to WHO ICD-10 classification and the prevalence of drugs administered according to WHO ATC system were analyzed. Potential drug-drug interactions were evaluated using AiDKlinik (R).ResultsIn total, 335 PSP and 275 non-ND patients were included in this analysis. The prevalence of diseases of the circulatory and the nervous system was higher in PSP at first level of ICD-10. Dorsopathies, diabetes mellitus, other nutritional deficiencies and polyneuropathies were more frequent in PSP at second level of ICD-10. In particular, the summed prevalence of cardiovascular and cerebrovascular diseases was higher in PSP patients. More drugs were administered in the PSP group leading to a greater percentage of patients with polypharmacy. Accordingly, the prevalence of potential drug-drug interactions was higher in PSP patients, especially severe and moderate interactions.ConclusionsPSP patients possess a characteristic profile of comorbidities, particularly diabetes and cardiovascular diseases. The eminent burden of comorbidities and resulting polypharmacy should be carefully considered when treating PSP patients.

引用

页码：782 / 793

页数：12

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