Preoperative low muscle mass and early postoperative outcomes in children undergoing living donor liver transplantation: A retrospective study

被引:2
作者
Jeong, Daun [1 ]
Lee, Sang-Wook [1 ]
Jang, Hwa-Young [1 ]
Kwon, Hye-Mee [2 ]
Shin, Won-Jung [2 ]
Song, In-Kyung [2 ,3 ]
机构
[1] Asan Med Ctr, Dept Anesthesiol & Pain Med, Seoul, South Korea
[2] Univ Ulsan, Asan Med Ctr, Dept Anesthesiol & Pain Med, Lab Cardiovasc Dynam,Coll Med, Seoul, South Korea
[3] Univ Ulsan, Dept Anesthesiol & Pain Med, Lab Cardiovasc Dynam, Asan Med Ctr,Coll Med, 88 Olymp ro 43 gil, Seoul 05505, South Korea
关键词
SKELETAL-MUSCLE; SARCOPENIA; GROWTH; IMPACT; VALUES; LENGTH; SCORE; STAY;
D O I
10.1097/LVT.0000000000000230
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Low skeletal muscle mass may develop in children with end-stage liver disease, affecting postoperative outcomes. We retrospectively investigated whether preoperative low muscle mass was associated with early postoperative outcomes in pediatric patients undergoing living donor liver transplantation (LDLT). Electronic medical records of children (age below 12 y) who underwent LDLT between February 1, 2007, and January 31, 2018, were reviewed. The cross-sectional areas of psoas, quadratus lumborum, and erector spinae muscles at the level of fourth-fifth lumbar intervertebral disks were measured using abdominal CT images, divided by the square of the height and were added to obtain the total skeletal muscle index (TSMI). The patients were divided into two groups according to the median TSMI in the second quintile (1859.1 mm(2)/m(2)). Complications in the early postoperative period (within 30 d after surgery) classified as Clavien-Dindo grade 3 or higher were considered major complications. Logistic regression analyses were performed to determine the association between preoperative low muscle mass and early postoperative outcomes. In the study population of 123 patients (median age, 14 mo; range, 8-38 mo) who underwent LDLT, 29% and 71% were classified in the low (mean TSMI, 1642.5 +/- 187.0 mm(2)/m(2)) and high (mean TSMI 2188.1 +/- 273.5 mm(2)/m(2)) muscle mass groups, respectively. The rates of major complications, mechanical ventilation >96 hours, intensive care unit stay >14 days, hospital stay >30 days, and in-hospital mortality were not significantly different between the 2 groups. Additionally, adverse outcomes according to pediatric end-stage liver disease scores and sex were not significantly different between the 2 groups. In conclusion, preoperative low muscle mass defined by TSMI was not associated with early postoperative outcomes in pediatric patients undergoing LDLT.
引用
收藏
页码:83 / 93
页数:11
相关论文
共 48 条
  • [1] Andropoulos DB., 2020, GREGORYS PEDIAT ANES, P1263
  • [2] A prospective study of prolonged stay in the intensive care unit: predictors and impact on resource utilization
    Arabi, Y
    Venkatesh, S
    Haddad, S
    Al Shimemeri, A
    Al Malik, S
    [J]. INTERNATIONAL JOURNAL FOR QUALITY IN HEALTH CARE, 2002, 14 (05) : 403 - 410
  • [3] Psoas as a sentinel muscle for sarcopenia: a flawed premise
    Baracos, Vickie E.
    [J]. JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, 2017, 8 (04) : 527 - 528
  • [4] Epidemiology of sarcopenia among the elderly in New Mexico
    Baumgartner, RN
    Koehler, KM
    Gallagher, D
    Romero, L
    Heymsfield, SB
    Ross, RR
    Garry, PJ
    Lindeman, RD
    [J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 1998, 147 (08) : 755 - 763
  • [5] Higher Mortality in Pediatric Liver Transplant Candidates With Sarcopenia
    Boster, Julia M.
    Browne, Lorna P.
    Pan, Zhaoxing
    Zhou, Wenru
    Ehrlich, Peter F.
    Sundaram, Shikha S.
    [J]. LIVER TRANSPLANTATION, 2021, 27 (06) : 808 - 817
  • [6] PELD score and posttransplant outcome in pediatric liver transplantation: A retrospective study of 100 recipients
    Bourdeaux, C
    Tri, TT
    Gras, J
    Sokal, E
    Otte, JB
    de Goyet, JD
    Reding, R
    [J]. TRANSPLANTATION, 2005, 79 (09) : 1273 - 1276
  • [7] Automated Segmentation of Abdominal Skeletal Muscle on Pediatric CT Scans Using Deep Learning
    Castiglione, James
    Somasundaram, Elanchezhian
    Gilligan, Leah A.
    Trout, Andrew T.
    Brady, Samuel
    [J]. RADIOLOGY-ARTIFICIAL INTELLIGENCE, 2021, 3 (02)
  • [8] Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment
    Chen, Liang-Kung
    Woo, Jean
    Assantachai, Prasert
    Auyeung, Tung-Wai
    Chou, Ming-Yueh
    Iijima, Katsuya
    Jang, Hak Chul
    Kang, Lin
    Kim, Miji
    Kim, Sunyoung
    Kojima, Taro
    Kuzuya, Masafumi
    Lee, Jenny S. W.
    Lee, Sang Yoon
    Lee, Wei-Ju
    Lee, Yunhwan
    Liang, Chih-Kuang
    Lim, Jae-Young
    Lim, Wee Shiong
    Peng, Li-Ning
    Sugimoto, Ken
    Tanaka, Tomoki
    Won, Chang Won
    Yamada, Minoru
    Zhang, Teimei
    Akishita, Masahiro
    Arai, Hidenori
    [J]. JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, 2020, 21 (03) : 300 - +
  • [9] Tanner's tempo of growth in adolescence: recent SITAR insights with the Harpenden Growth Study and ALSPAC
    Cole, T. J.
    [J]. ANNALS OF HUMAN BIOLOGY, 2020, 47 (02) : 181 - 198
  • [10] The relationship between Insulin-like Growth Factor 1, sex steroids and timing of the pubertal growth spurt
    Cole, T. J.
    Ahmed, M. L.
    Preece, M. A.
    Hindmarsh, P.
    Dunger, D. B.
    [J]. CLINICAL ENDOCRINOLOGY, 2015, 82 (06) : 862 - 869