Regulatory role of exosomes in colorectal cancer progression and potential as biomarkers

被引：6
作者：
Hui, Juan [1 ,2 ,3 ]
Zhou, Mingzhen [2 ,3 ]
An, Guangzhou [1 ,4 ]
Zhang, Hui [1 ,5 ]
Lu, Yuanyuan [1 ,2 ,3 ]
Wang, Xin [1 ]
Zhao, Xiaodi [2 ,3 ]
机构：
[1] Air Force Med Univ, Tangdu Hosp, Dept Gastroenterol, Xian 710038, Peoples R China
[2] Air Force Med Univ, Xijing Hosp Digest Dis, State Key Lab Canc Biol, Xian 710032, Peoples R China
[3] Air Force Med Univ, Xijing Hosp Digest Dis, Natl Clin Res Ctr Digest Dis, Xian 710032, Peoples R China
[4] Air Force Med Univ, Fac Prevent Med, Dept Radiat Protect Med, Minist Educ,Key Lab Hazard Assessment & Control S, Xian 710032, Peoples R China
[5] Air Force Med Univ, Xijing Hosp Digest Dis, Natl Clin Res Ctr Digest Dis, Xian 710032, Peoples R China
来源：
CANCER BIOLOGY & MEDICINE | 2023年 / 20卷 / 08期
基金：
中国国家自然科学基金;
关键词：
Colorectal cancer; exosome; immunoregulation; immunotherapy; metastasis; TUMOR MICROENVIRONMENT; MICROSATELLITE INSTABILITY; MACROPHAGE POLARIZATION; EXTRACELLULAR VESICLES; PROMOTES METASTASIS; B-CELLS; SECRETION; FIBROBLASTS; EXPRESSION; BIOLOGY;
D O I：
10.20892/j.issn.2095-3941.2023.0119
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Colorectal cancer (CRC) remains an enormous challenge to human health worldwide. Unfortunately, the mechanism underlying CRC progression is not well understood. Mounting evidence has confirmed that exosomes play a vital role in CRC progression, which has attracted extensive attention among researchers. In addition to acting as messengers between CRC cells, exosomes also participate in the CRC immunomodulatory process and reshape immune function. As stable message carriers and liquid biopsy option under development, exosomes are promising biomarkers in the diagnosis or treatment of CRC. In this review we have described and analyzed the biogenesis and release of exosomes and current research on the role of exosomes in immune regulation and metastasis of CRC. Moreover, we have discussed candidate exosomal molecules as potential biomarkers to diagnose CRC, predict CRC progression, or determine CRC chemoresistance, and described the significance of exosomes in the immunotherapy of CRC. This review provides insight to further understand the role of exosomes in CRC progression and identify valuable biomarkers that facilitate the clinical management of CRC patients.
引用
收藏
页码：575 / 598
页数：24
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