The VEGF protein levels, miR-101-3p, and miR-122-5p are dysregulated in plasma from adolescents with major depression

被引：6

作者：

Krivosova, Michaela ^{[1
]}

Adamcakova, Jana ^{[2
]}

Kaadt, Erik ^{[3
]}

Mumm, Birgitte Hviid ^{[3
]}

Dvorska, Dana ^{[1
]}

Brany, Dusan ^{[1
]}

Dankova, Zuzana ^{[1
]}

Dohal, Matus ^{[1
,4
]}

Samec, Marek ^{[5
]}

Ferencova, Nikola ^{[1
]}

Tonhajzerova, Ingrid ^{[2
,6
]}

Ondrejka, Igor ^{[6
]}

Hrtanek, Igor ^{[6
]}

Hutka, Peter ^{[6
]}

Oppa, Miloslav ^{[6
]}

Mokry, Juraj ^{[4
]}

Elfving, Betina ^{[3
,7
]}

机构：

[1] Comenius Univ, Jessenius Fac Med Martin, Biomed Ctr Martin, Martin, Slovakia

[2] Comenius Univ, Jessenius Fac Med Martin, Dept Physiol, Martin, Slovakia

[3] Aarhus Univ, Dept Clin Med, Translat Neuropsychiat Unit, Aarhus, Denmark

[4] Comenius Univ, Jessenius Fac Med Martin, Dept Pharmacol, Martin, Slovakia

[5] Comenius Univ, Jessenius Fac Med Martin, Dept Pathol Physiol, Martin, Slovakia

[6] Comenius Univ, Univ Hosp Martin, Jessenius Fac Med Martin, Psychiat Clin, Martin, Slovakia

[7] Aarhus Univ, Dept Clin Med, Translat Neuropsychiat Unit, Palle Juul Jensens Blvd 11, A601, DK-8200 Aarhus N, Denmark

来源：

JOURNAL OF AFFECTIVE DISORDERS | 2023年 / 334卷

关键词：

Major depressive disorder; VEGF; miRNA; Biomarkers; Adolescents; ENDOTHELIAL GROWTH-FACTOR; NEUROTROPHIC FACTORS; DISORDER; MICRORNA; SERUM; ASSOCIATION; EXPRESSION; AGE;

D O I：

10.1016/j.jad.2023.04.094

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Major depressive disorder (MDD) is a common and serious psychiatric disorder that affects millions of individuals worldwide. Although the underlying mechanisms are still poorly understood, mounting evidence is indicating a role of growth factors, among them the vascular endothelial growth factor (VEGF or VEGFA).Methods: To further explore the importance of VEGF, the plasma protein VEGF levels in hospitalized children and adolescents with MDD were investigated before and after antidepressant treatment (10 days on average) and compared to healthy controls. Subsequently, an expression study with 28 microRNAs (miRNAs) targeting VEGF was performed. The study included 39 hospitalized children and adolescents with MDD and 20 healthy controls.Results: VEGF protein levels were significantly increased in depressed adolescents compared to healthy controls and a short antidepressant treatment significantly decreased the levels in both adolescents and children. In continuation, we found that miR-101-3p was up-and miR-122-5p was down-regulated in depressed adolescents compared to healthy controls and that factors such as age, sex, antidepressant treatment, and haemolysis of the blood samples impact the miRNA results.Limitations: Small sample size and short treatment period with different pharmacological treatment (fluoxetine, vortioxetine, and venlafaxine).Conclusion: This study substantiates the use of peripheral VEGF as a biomarker of MDD in children and ado-lescents and highlights the importance of understanding the underlying regulatory mechanisms.

引用

页码：60 / 68

页数：9

共 45 条

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