Targeting STING to promote antitumor immunity

被引：74

作者：

Chin, Emily N. ^{[1
]}

Sulpizio, Ariana ^{[1
]}

Lairson, Luke L. ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

TRENDS IN CELL BIOLOGY | 2023年 / 33卷 / 03期

关键词：

5,6-DIMETHYLXANTHENONE-4-ACETIC ACID DMXAA; CYCLIC DI-GMP; R71H-G230A-R293Q HUMAN TMEM173; I INTERFERON; ACTIVATION; POTENT; CELLS; RECOGNITION; METASTASIS; SIGNALS;

D O I：

10.1016/j.tcb.2022.06.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pharmacology-based methods that promote antitumor immunity have the potential to be highly efficacious while avoiding the systemic cytotoxicity associ-ated with traditional chemotherapies. Activation of type I interferon (IFN) signal-ing in antigen-presenting cell types [e.g., macrophages and dendritic cells (DCs)] is critical, if not essential, for inducing a tumor-specific adaptive immune response, including the activation of cytolytic CD8 T cells. In the context of pro-moting antitumor immunity, the cyclic GMP-AMP synthase/stimulator of IFN genes (cGAS/STING) pathway has emerged as a principal regulator of essential type I IFN signaling. As such, STING represents a highly attractive target for de-veloping a first-in-class immunotherapy, albeit one with a potential for significant cell type-and downstream pathway-dependent on-target toxicities, as well as conceivable pharmacogenomic liabilities.

引用

收藏

页码：189 / 203

页数：15

相关论文

共 62 条

[11] STING Pathway Activation Stimulates Potent Immunity against Acute Myeloid Leukemia [J].

Curran, Emily ;

Chen, Xiufen ;

Corrales, Leticia ;

Kline, Douglas E. ;

Dubensky, Thomas W., Jr. ;

Duttagupta, Priyanka ;

Kortylewski, Marcin ;

Kline, Justin .

CELL REPORTS, 2016, 15 (11) :2357-2366

[12] The cGAS-STING pathway as a therapeutic target in inflammatory diseases [J].

Decout, Alexiane ;

Katz, Jason D. ;

Venkatraman, Shankar ;

Ablasser, Andrea .

NATURE REVIEWS IMMUNOLOGY, 2021, 21 (09) :548-569

[13] STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity [J].

Demaria, Olivier ;

De Gassart, Aude ;

Coso, Sanja ;

Gestermann, Nicolas ;

Di Domizio, Jeremy ;

Flatz, Lukas ;

Gaide, Olivier ;

Michielin, Olivier ;

Hwu, Patrick ;

Petrova, Tatiana V. ;

Martinon, Fabio ;

Modlin, Robert L. ;

Speiser, Daniel E. ;

Gilliet, Michel .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (50) :15408-15413

[14] STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors [J].

Deng, Liufu ;

Liang, Hua ;

Xu, Meng ;

Yang, Xuanming ;

Burnette, Byron ;

Arina, Ainhoa ;

Li, Xiao-Dong ;

Mauceri, Helena ;

Beckett, Michael ;

Darga, Thomas ;

Huang, Xiaona ;

Gajewski, Thomas F. ;

Chen, Zhijian J. ;

Fu, Yang-Xin ;

Weichselbaum, Ralph R. .

IMMUNITY, 2014, 41 (05) :843-852

[15] Type I interferon is selectively required by dendritic cells for immune rejection of tumors [J].

Diamond, Mark S. ;

Kinder, Michelle ;

Matsushita, Hirokazu ;

Mashayekhi, Mona ;

Dunn, Gavin P. ;

Archambault, Jessica M. ;

Lee, Hsiaoju ;

Arthur, Cora D. ;

White, J. Michael ;

Kalinke, Ulrich ;

Murphy, Kenneth M. ;

Schreiber, Robert D. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2011, 208 (10) :1989-2003

[16] Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage [J].

Dunphy, Gillian ;

Flannery, Sinead M. ;

Almine, Jessica F. ;

Connolly, Dympna J. ;

Paulus, Christina ;

Jonsson, Kasper L. ;

Jakobsen, Martin R. ;

Nevels, Michael M. ;

Bowie, Andrew G. ;

Unterholzner, Leonie .

MOLECULAR CELL, 2018, 71 (05) :745-+

[17] STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition [J].

Ergun, Sabrina L. ;

Fernandez, Daniel ;

Weiss, Thomas M. ;

Li, Lingyin .

CELL, 2019, 178 (02) :290-+

[18] STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade [J].

Fu, Juan ;

Kanne, David B. ;

Leong, Meredith ;

Glickman, Laura Hix ;

McWhirter, Sarah M. ;

Lemmens, Edward ;

Mechette, Ken ;

Leong, Justin J. ;

Lauer, Peter ;

Liu, Weiqun ;

Sivick, Kelsey E. ;

Zeng, Qi ;

Soares, Kevin C. ;

Zheng, Lei ;

Portnoy, Daniel A. ;

Woodward, Joshua J. ;

Pardoll, Drew M. ;

Dubensky, Thomas W., Jr. ;

Kim, Young .

SCIENCE TRANSLATIONAL MEDICINE, 2015, 7 (283)

[19] Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8α+ dendritic cells [J].

Fuertes, Mercedes B. ;

Kacha, Aalok K. ;

Kline, Justin ;

Woo, Seng-Ryong ;

Kranz, David M. ;

Murphy, Kenneth M. ;

Gajewski, Thomas F. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2011, 208 (10) :2005-2016

[20] The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3 [J].

Gaidt, Moritz M. ;

Ebert, Thomas S. ;

Chauhan, Dhruv ;

Ramshorn, Katharina ;

Pinci, Francesca ;

Zuber, Sarah ;

O'Duill, Fionan ;

Schmid-Burgk, Jonathan L. ;

Hoss, Florian ;

Buhmann, Raymund ;

Wittmann, Georg ;

Latz, Eicke ;

Subklewe, Marion ;

Hornung, Veit .

CELL, 2017, 171 (05) :1110-+

← 1 2 3 4 5 6 7 →