Targeting STING to promote antitumor immunity

被引：74

作者：

Chin, Emily N. ^{[1
]}

Sulpizio, Ariana ^{[1
]}

Lairson, Luke L. ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

TRENDS IN CELL BIOLOGY | 2023年 / 33卷 / 03期

关键词：

5,6-DIMETHYLXANTHENONE-4-ACETIC ACID DMXAA; CYCLIC DI-GMP; R71H-G230A-R293Q HUMAN TMEM173; I INTERFERON; ACTIVATION; POTENT; CELLS; RECOGNITION; METASTASIS; SIGNALS;

D O I：

10.1016/j.tcb.2022.06.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pharmacology-based methods that promote antitumor immunity have the potential to be highly efficacious while avoiding the systemic cytotoxicity associ-ated with traditional chemotherapies. Activation of type I interferon (IFN) signal-ing in antigen-presenting cell types [e.g., macrophages and dendritic cells (DCs)] is critical, if not essential, for inducing a tumor-specific adaptive immune response, including the activation of cytolytic CD8 T cells. In the context of pro-moting antitumor immunity, the cyclic GMP-AMP synthase/stimulator of IFN genes (cGAS/STING) pathway has emerged as a principal regulator of essential type I IFN signaling. As such, STING represents a highly attractive target for de-veloping a first-in-class immunotherapy, albeit one with a potential for significant cell type-and downstream pathway-dependent on-target toxicities, as well as conceivable pharmacogenomic liabilities.

引用

页码：189 / 203

页数：15

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