Critical Review on the Different Roles of Exosomes in TNBC and Exosomal-Mediated Delivery of microRNA/siRNA/lncRNA and Drug Targeting Signalling Pathways in Triple-Negative Breast Cancer

被引:13
作者
Banerjee, Manosi [1 ]
Rajeswari, Vijayarangan Devi [1 ]
机构
[1] Vellore Inst Technol, Sch Biosci & Technol, Vellore 632014, Tamil Nadu, India
来源
MOLECULES | 2023年 / 28卷 / 04期
关键词
triple-negative breast cancer; exosomes; biomarkers; therapeutics; signalling; drug-resistant; EPITHELIAL-MESENCHYMAL TRANSITION; MACROPHAGE-DERIVED EXOSOMES; EXTRACELLULAR VESICLES; IN-VITRO; PROLIFERATION; CHEMOTHERAPY; MIGRATION; CELLS; METASTASIS; RECEPTOR;
D O I
10.3390/molecules28041802
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Triple-negative breast cancer is the most potent metastatic type of breast cancer that can spread to other body parts. Chemotherapy and surgical intervention are the sole treatments for TNBC, owing to the scarcity of therapeutic targets. Manipulation of the membranes as per the desired targets of exosomes has recently gained much attention as a drug delivery method. Despite their known roles in different diseases, very few studies have focused on signalling that triggers the metastasis of triple-negative breast cancer to other body parts by exosomes. This article highlights the significant roles of exosomes associated with TNBC, the involvement of exosomes in breast cancer diagnosis, progression, and the treatment of triple-negative breast cancer by the exosomes as a drug delivery system. This review paper also illustrates the role of exosomes in initiating EMT in breast cancer, including novel signalling.
引用
收藏
页数:20
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