Congenital Anomalies of the Kidney and Urinary Tract: A Continuum of Care

被引：1

作者：

Lange-Sperandio, Baerbel ^{[1
,5
]}

Anders, Hans-Joachim ^{[2
]}

Stehr, Maximilian ^{[3
]}

Chevalier, Robert L. ^{[4
]}

Klaus, Richard ^{[1
]}

机构：

[1] Ludwig Maximilians Univ Munchen, Dr Hauner Childrens Hosp, Dept Pediat, Div Pediat Nephrol, Munich, Germany

[2] Univ Hosp, Ludwig Maximilian Univ Munich, Dept Med 4, Div Nephrol, Munich, Germany

[3] Cnopfsche Kinderklin, Dept Pediat Surg & Pediat Urol, Nurnberg, Germany

[4] Univ Virginia, Dept Pediat, Charlottesville, VA USA

[5] Dr Hauner Childrens Hosp, LMU Munich, Lindwurmstr 4, D-80337 Munich, Germany

来源：

SEMINARS IN NEPHROLOGY | 2023年 / 43卷 / 04期

关键词：

CAKUT; chronic kidney disease; end-stage kidney disease; STAGE RENAL-DISEASE; YOUNG-ADULTS; CHILDREN; RISK; OUTCOMES; MALFORMATIONS; PROGRESSION; CKD; EPIDEMIOLOGY; METAANALYSIS;

D O I：

10.1016/j.semnephrol.2023.151433

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Congenital anomalies of the kidney and urinary tract (CAKUT) are the leading cause of kidney failure in children and adolescents. CAKUT describes a wide spectrum of structural disorders with a prenatal origin. The etiology of CAKUT is multifactorial, including environmental, nongenetic, and genetic causes that impact kidney development as well as upper and lower urinary tract development. Adult nephrologists who treat patients with CAKUT may be challenged by the underlying diseases they are not familiar with and the accumulation of chronic kidney disease complications in childhood. This article discusses CAKUT etiology and presentation, the course during childhood and adolescence, as well as adult issues in CAKUT patients including CKD complications, urologic interventions, and genetic counseling. A smooth transition of CAKUT patients from pediatric to adult care can be challenging.

引用

页数：12

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