Noncoding rules of survival: epigenetic regulation of normal and malignant hematopoiesis

被引：2

作者：

Wallace, Lashanale ^{[1
]}

Obeng, Esther A. ^{[1
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Oncol, Memphis, TN 38105 USA

来源：

FRONTIERS IN MOLECULAR BIOSCIENCES | 2023年 / 10卷

关键词：

epigenetics; hematopoiesis; histone modification; DNA methylation; clonal hematopoiesis; RNA modification; splicing; CELL SELF-RENEWAL; HISTONE ACETYLTRANSFERASE ACTIVITY; METHYLTRANSFERASE GENE EZH2; INTRON RETENTION PROGRAM; ACUTE MYELOID-LEUKEMIA; STEM-CELLS; MYELODYSPLASTIC SYNDROME; CLONAL HEMATOPOIESIS; TRANSCRIPTION FACTORS; CHROMATIN SIGNATURES;

D O I：

10.3389/fmolb.2023.1273046

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hematopoiesis is an essential process for organismal development and homeostasis. Epigenetic regulation of gene expression is critical for stem cell self-renewal and differentiation in normal hematopoiesis. Increasing evidence shows that disrupting the balance between self-renewal and cell fate decisions can give rise to hematological diseases such as bone marrow failure and leukemia. Consequently, next-generation sequencing studies have identified various aberrations in histone modifications, DNA methylation, RNA splicing, and RNA modifications in hematologic diseases. Favorable outcomes after targeting epigenetic regulators during disease states have further emphasized their importance in hematological malignancy. However, these targeted therapies are only effective in some patients, suggesting that further research is needed to decipher the complexity of epigenetic regulation during hematopoiesis. In this review, an update on the impact of the epigenome on normal hematopoiesis, disease initiation and progression, and current therapeutic advancements will be discussed.

引用

页数：17

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