Regulatory T cells in allergic inflammation

被引：12

作者：

Benamar, Mehdi ^{[1
,2
]}

Chen, Qian ^{[1
,2
]}

Martinez-Blanco, Monica ^{[1
,2
]}

Chatila, Talal A. ^{[1
,2
]}

机构：

[1] Boston Childrens Hosp, Div Immunol, Boston, MA 02115 USA

[2] Harvard Med Sch, Dept Pediat, Boston, MA USA

来源：

SEMINARS IN IMMUNOLOGY | 2023年 / 70卷

基金：

美国国家卫生研究院;

关键词：

SYNCYTIAL VIRUS-INFECTION; TUFT CELLS; ATOPIC-DERMATITIS; TYPE-2; IMMUNITY; IMMUNOLOGICAL-TOLERANCE; PULMONARY EOSINOPHILIA; AIRWAY INFLAMMATION; FOOD ALLERGY; ASTHMA; PROMOTES;

D O I：

10.1016/j.smim.2023.101847

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Regulatory T (Treg) cells maintain immune tolerance to allergens at the environmental interfaces in the airways, skin and gut, marshalling in the process distinct immune regulatory circuits operative in the respective tissues. Treg cells are coordinately mobilized with allergic effector mechanisms in the context of a tissue protective allergic inflammatory response against parasites, toxins and potentially harmful allergens, serving to both limit the inflammation and promote local tissue repair. Allergic diseases are associated with subverted Treg cell responses whereby a chronic allergic inflammatory environment can skew Treg cells toward pathogenic phenotypes that both perpetuate and aggravate disease. Interruption of Treg cell subversion in chronic allergic inflammatory conditions may thus provide novel therapeutic strategies by re-establishing effective immune regulation.

引用

页数：8

共 155 条

[1] Oral immunotherapy with omalizumab reverses the Th2 cell-like programme of regulatory T cells and restores their function [J].

Abdel-Gadir, A. ;

Schneider, L. ;

Casini, A. ;

Charbonnier, L. -M. ;

Little, S. V. ;

Harrington, T. ;

Umetsu, D. T. ;

Rachid, R. ;

Chatila, T. A. .

CLINICAL AND EXPERIMENTAL ALLERGY, 2018, 48 (07) :825-836

[2] Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy [J].

Abdel-Gadir, Azza ;

Stephen-Victor, Emmanuel ;

Gerber, Georg K. ;

Noval Rivas, Magali ;

Wang, Sen ;

Harb, Hani ;

Wang, Leighanne ;

Li, Ning ;

Crestani, Elena ;

Spielman, Sara ;

Secor, William ;

Biehl, Heather ;

Dibendetto, Nicholas ;

Dong, Xiaoxi ;

Umetsu, Dale T. ;

Bry, Lynn ;

Rachid, Rima ;

Chatila, Talal A. .

NATURE MEDICINE, 2019, 25 (07) :1164-+

[3]

Abdel-Gadir Azza, 2018, F1000Res, V7, P38, DOI 10.12688/f1000research.12650.1

[4] Novel antigen-presenting cell imparts Treg-dependent tolerance to gut microbiota [J].

Akagbosu, Blossom ;

Tayyebi, Zakieh ;

Shibu, Gayathri ;

Iza, Yoselin A. Paucar ;

Deep, Deeksha ;

Parisotto, Yollanda Franco ;

Fisher, Logan ;

Pasolli, H. Amalia ;

Thevin, Valentin ;

Elmentaite, Rasa ;

Knott, Maximilian ;

Hemmers, Saskia ;

Jahn, Lorenz ;

Friedrich, Christin ;

Verter, Jacob ;

Wang, Zhong-Min ;

van den Brink, Marcel ;

Gasteiger, Georg ;

Gruenewald, Thomas G. P. ;

Marie, Julien C. ;

Leslie, Christina ;

Rudensky, Alexander Y. ;

Brown, Chrysothemis C. .

NATURE, 2022, 610 (7933) :752-+

[5] Type 2 immunity in the skin and lungs [J].

Akdis, Cezmi A. ;

Arkwright, Peter D. ;

Bruggen, Marie-Charlotte ;

Busse, William ;

Gadina, Massimo ;

Guttman-Yassky, Emma ;

Kabashima, Kenji ;

Mitamura, Yasutaka ;

Vian, Laura ;

Wu, Jianni ;

Palomares, Oscar .

ALLERGY, 2020, 75 (07) :1582-1605

[6] A Weaning Reaction to Microbiota Is Required for Resistance to Immunopathologies in the Adult [J].

Al Nabhani, Ziad ;

Dulauroy, Sophie ;

Marques, Rute ;

Cousu, Clara ;

Al Bounny, Shahed ;

Dejardin, Francois ;

Sparwasser, Tim ;

Berard, Marion ;

Cerf-Bensussan, Nadine ;

Eberl, Gerard .

IMMUNITY, 2019, 50 (05) :1276-+

[7] Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation [J].

Ali, Niwa ;

Zirak, Bahar ;

Rodriguez, Robert Sanchez ;

Pauli, Mariela L. ;

Hong-An Truong ;

Lai, Kevin ;

Ahn, Richard ;

Corbin, Kaitlin ;

Lowe, Margaret M. ;

Scharschmidt, Tiffany C. ;

Taravati, Keyon ;

Tan, Madeleine R. ;

Ricardo-Gonzalez, Roberto R. ;

Nosbaum, Audrey ;

Bertolini, Marta ;

Liao, Wilson ;

Nestle, Frank O. ;

Paus, Ralf ;

Cotsarelis, George ;

Abbas, Abul K. ;

Rosenblum, Michael D. .

CELL, 2017, 169 (06) :1119-+

[8] A Distinct Function of Regulatory T Cells in Tissue Protection [J].

Arpaia, Nicholas ;

Green, Jesse A. ;

Moltedo, Bruno ;

Arvey, Aaron ;

Hemmers, Saskia ;

Yuan, Shaopeng ;

Treuting, Piper M. ;

Rudensky, Alexander Y. .

CELL, 2015, 162 (05) :1078-1089

[9] Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation [J].

Asano, M ;

Toda, M ;

Sakaguchi, N ;

Sakaguchi, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (02) :387-396

[10] Succinate Produced by Intestinal Microbes Promotes Specification of Tuft Cells to Suppress Ileal Inflammation [J].

Banerjee, Amrita ;

Herring, Charles A. ;

Chen, Bob ;

Kim, Hyeyon ;

Simmons, Alan J. ;

Southard-Smith, Austin N. ;

Allaman, Margaret M. ;

White, James R. ;

Macedonia, Mary C. ;

Mckinley, Eliot T. ;

Ramirez-Solano, Marisol A. ;

Scoville, Elizabeth A. ;

Liu, Qi ;

Wilson, Keith T. ;

Coffey, Robert J. ;

Washington, M. Kay ;

Goettel, Jeremy A. ;

Lau, Ken S. .

GASTROENTEROLOGY, 2020, 159 (06) :2101-2115.e5

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