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Effect and mechanisms of resveratrol in animal models of ischemic stroke: A systematic review and Bayesian meta-analysis
被引:3
作者:
Lopez-Morales, Mikahela A.
[1
]
Castello-Ruiz, Maria
[1
,2
]
Burguete, Maria C.
[1
,3
,7
]
Hervas, David
[4
]
Perez-Pinzon, Miguel A.
[5
]
Salom, Juan B.
[1
,3
,6
]
机构:
[1] Inst Invest Sanitaria La Fe, Unidad Mixta Invest Cerebrovasc, Valencia, Spain
[2] Univ Valencia, Dept Biol Celular Biol Func & Antropol Fis, Valencia, Spain
[3] Univ Valencia, Dept Fisiol, Valencia, Spain
[4] Univ Politecn Valencia, Dept Estadist & Invest Operat Aplicadas & Calidad, Valencia, Spain
[5] Univ Miami, Miller Sch Med, Dept Neurol, Peritz Scheinberg Cerebral Vasc Dis Res Labs, Miami, FL USA
[6] Inst Invest Sanitaria La Fe, Unidad Mixta Invest Cerebrovasc, Torre, Torre A,Lab 5-05,Ave Fernando Abril Martorell 106, Valencia 46026, Spain
[7] Univ Valencia, Dept Fisiol, Ave Vicente Andres S-N, Burjassot 46100, Valencia, Spain
关键词:
Animal models;
Bayesian meta-analysis;
cerebroprotection;
ischemic stroke;
resveratrol;
CEREBRAL ISCHEMIA/REPERFUSION INJURY;
OXIDATIVE STRESS;
REPERFUSION INJURY;
RAT MODEL;
PROVIDES NEUROPROTECTION;
NEUROLOGICAL FUNCTION;
TRANS-RESVERATROL;
EXTENDED WINDOW;
UP-REGULATION;
BRAIN-DAMAGE;
D O I:
10.1177/0271678X231206236
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Resveratrol (RSV) holds promise as cerebroprotective treatment in cerebral ischemia. This systematic review aims to assess the effects and mechanisms of RSV in animal models of ischemic stroke. We searched Medline, Embase and Web of Science to identify 75 and 57 eligible rodent studies for qualitative and quantitative syntheses, respectively. Range of evidence met 10 of 13 STAIR criteria. Median (Q1, Q3) quality score was 7 (5, 8) on the CAMARADES 15-item checklist. Bayesian meta-analysis showed SMD estimates (95% CI) favoring RSV: infarct size (-1.72 [-2.03; -1.41]), edema size (-1.61 [-2.24; -0.98]), BBB impairment (-1.85 [-2.54; -1.19]), neurofunctional impairment (-1.60 [-1.92; -1.29]), and motor performance (1.39 [0.64; 2.08]); and less probably neuronal survival (0.63 [-1.40; 2.48]) and apoptosis (-0.96 [-2.87; 1.02]). Species (rat vs mouse) was associated to a larger benefit. Sensitivity analyses confirmed robustness of the estimates. Reduction of oxidative stress, inflammation, and apoptosis underlie these effects. Our results quantitatively state the beneficial effects of RSV on structural and functional outcomes in rodent stroke models, update the evidence on the mechanisms of action, and provide an exhaustive list of targeted signaling pathways. Current evidence highlights the need for conducting further high-quality preclinical research to better inform clinical research.
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页码:2013 / 2028
页数:16
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