Current Advances of Mitochondrial Dysfunction and Cardiovascular Disease and Promising Therapeutic Strategies

被引：10
作者：
Xia, Dexiang [1 ]
Liu, Yue [1 ]
Wu, Peng [2 ]
Wei, Dangheng [1 ,3 ]
机构：
[1] Univ South China, Hengyang Med Sch, Hunan Int Sci & Technol Cooperat Base Arterioscler, Inst Cardiovasc Dis,Key Lab Arteriosclerol Hunan P, Hengyang, Peoples R China
[2] Hengyang Maternal & Child Hlth Hosp, Hengyang, Peoples R China
[3] Univ South China, Hengyang 421001, Hunan, Peoples R China
来源：
AMERICAN JOURNAL OF PATHOLOGY | 2023年 / 193卷 / 10期
基金：
中国国家自然科学基金;
关键词：
ELECTRON-TRANSPORT CHAIN; ISCHEMIA-REPERFUSION INJURY; DNA COPY NUMBER; OXIDATIVE STRESS; HEART-FAILURE; DOUBLE-BLIND; MYOCARDIAL-ISCHEMIA; DOWN-REGULATION; KETONE-BODIES; BIOGENESIS;
D O I：
10.1016/j.ajpath.2023.06.013
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Mitochondria are cellular power stations and essential organelles for maintaining cellular homeostasis. Dysfunctional mitochondria have emerged as a key factor in the occurrence and development of car-diovascular disease. This review focuses on advances in the relationship between mitochondrial dysfunction and cardiovascular diseases such as atherosclerosis, heart failure, myocardial ischemia reperfusion injury, and pulmonary arterial hypertension. The clinical value and challenges of mitochondria-targeted strategies, including mitochondria-targeted antioxidants, mitochondrial quality control modulators, mitochondrial function protectors, mitochondrial biogenesis promoters, and recently developed mitochondrial transplants, are also discussed. (Am J Pathol 2023,
引用
收藏
页码：1485 / 1500
页数：16
相关论文
共 133 条
  • [1] Nicotinamide for the treatment of heart failure with preserved ejection fraction
    Abdellatif, Mahmoud
    Trummer-Herbst, Viktoria
    Koser, Franziska
    Durand, Sylvere
    Adao, Rui
    Vasques-Novoa, Francisco
    Freundt, Johanna K.
    Voglhuber, Julia
    Pricolo, Maria-Rosaria
    Kasa, Michael
    Turk, Clara
    Aprahamian, Fanny
    Herrero-Galan, Elias
    Hofer, Sebastian J.
    Pendl, Tobias
    Rech, Lavinia
    Kargl, Julia
    Anto-Michel, Nathaly
    Ljubojevic-Holzer, Senka
    Schipke, Julia
    Brandenberger, Christina
    Auer, Martina
    Schreiber, Renate
    Koyani, Chintan N.
    Heinemann, Akos
    Zirlik, Andreas
    Schmidt, Albrecht
    von Lewinski, Dirk
    Scherr, Daniel
    Rainer, Peter P.
    von Maltzahn, Julia
    Muhlfeld, Christian
    Kruger, Marcus
    Frank, Sasa
    Madeo, Frank
    Eisenberg, Tobias
    Prokesch, Andreas
    Leite-Moreira, Adelino F.
    Lourenco, Andre P.
    Alegre-Cebollada, Jorge
    Kiechl, Stefan
    Linke, Wolfgang A.
    Kroemer, Guido
    Sedej, Simon
    [J]. SCIENCE TRANSLATIONAL MEDICINE, 2021, 13 (580)
  • [2] Decreased endothelial nitric oxide synthase expression and function contribute to impaired mitochondrial biogenesis and oxidative stress in fetal lambs with persistent pulmonary hypertension
    Afolayan, Adeleye J.
    Eis, Annie
    Alexander, Maxwell
    Michalkiewicz, Teresa
    Teng, Ru-Jeng
    Lakshminrusimha, Satyan
    Konduri, Girija G.
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2016, 310 (01) : L40 - L49
  • [3] Pleiotropic effects of mdivi-1 in altering mitochondrial dynamics, respiration, and autophagy in cardiomyocytes
    Aishwarya, Richa
    Alam, Shafiul
    Abdullah, Chowdhury S.
    Morshed, Mahboob
    Nitu, Sadia S.
    Panchatcharam, Manikandan
    Miriyala, Sumitra
    Kevil, Christopher G.
    Bhuiyan, Md Shenuarin
    [J]. REDOX BIOLOGY, 2020, 36
  • [4] Glutamine supplementation can reduce some atherosclerosis markers after exhaustive exercise in young healthy males
    Alipanah-Moghadam, Reza
    Molazadeh, Leila
    Jafari-Suha, Zeinab
    Naghizadeh-Baghi, Abbas
    Mohajeri, Mahsa
    Nemati, Ali
    [J]. NUTRITION, 2022, 94
  • [5] Trend analysis of cardiovascular disease mortality, incidence, and mortality-to-incidence ratio: results from global burden of disease study 2017
    Amini, Maedeh
    Zayeri, Farid
    Salehi, Masoud
    [J]. BMC PUBLIC HEALTH, 2021, 21 (01)
  • [6] Association of Mitochondrial DNA Copy Number With Cardiovascular Disease
    Ashar, Foram N.
    Zhang, Yiyi
    Longchamps, Ryan J.
    Lane, John
    Moes, Anna
    Grove, Megan L.
    Mychaleckyj, Josyf C.
    Taylor, Kent D.
    Coresh, Josef
    Rotter, Jerome I.
    Boerwinkle, Eric
    Pankratz, Nathan
    Guallar, Eliseo
    Arking, Dan E.
    [J]. JAMA CARDIOLOGY, 2017, 2 (11) : 1247 - 1255
  • [7] The Failing Heart Relies on Ketone Bodies as a Fuel
    Aubert, Gregory
    Martin, Ola J.
    Horton, Julie L.
    Lai, Ling
    Vega, Rick B.
    Leone, Teresa C.
    Koves, Timothy
    Gardell, Stephen J.
    Krueger, Marcus
    Hoppel, Charles L.
    Lewandowski, E. Douglas
    Crawford, Peter A.
    Muoio, Deborah M.
    Kelly, Daniel P.
    [J]. CIRCULATION, 2016, 133 (08) : 698 - 705
  • [8] Direct noninvasive estimation of myocardial tricarboxylic acid cycle flux in vivo using hyperpolarized 13C magnetic resonance
    Bastiaansen, Jessica A. M.
    Cheng, Tian
    Lei, Hongxia
    Gruetter, Rolf
    Comment, Arnaud
    [J]. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2015, 87 : 129 - 137
  • [9] Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure
    Bedi, Kenneth C., Jr.
    Snyder, Nathaniel W.
    Brandimarto, Jeffrey
    Aziz, Moez
    Mesaros, Clementina
    Worth, Andrew J.
    Wang, Linda L.
    Javaheri, Ali
    Blair, Ian A.
    Margulies, Kenneth B.
    Rame, J. Eduardo
    [J]. CIRCULATION, 2016, 133 (08) : 706 - 716
  • [10] PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function
    Billia, Filio
    Hauck, Ludger
    Konecny, Filip
    Rao, Vivek
    Shen, Jie
    Mak, Tak Wah
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (23) : 9572 - 9577
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