Circadian regulation of liver function: from molecular mechanisms to disease pathophysiology

被引：33
作者：
Bolshette, Nityanand [1 ]
Ibrahim, Hussam [2 ]
Reinke, Hans [2 ]
Asher, Gad [1 ]
机构：
[1] Weizmann Inst Sci, Dept Biomol Sci, Rehovot, Israel
[2] Univ Dusseldorf, Inst Clin Chem & Lab Diagnost, Med Fac, Dusseldorf, Germany
来源：
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY | 2023年 / 20卷 / 11期
基金：
欧洲研究理事会;
关键词：
REV-ERB-ALPHA; NIGHT-SHIFT WORK; ACTIVATED PROTEIN-KINASE; CLOCK GENE; METABOLIC SYNDROME; LIPID-METABOLISM; GUT MICROBIOTA; TRANSCRIPTIONAL ARCHITECTURE; MITOCHONDRIAL DYNAMICS; MAMMALIAN CLOCK;
D O I：
10.1038/s41575-023-00792-1
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
This Review discusses the role of the circadian clock in liver homeostasis, and how dysfunction of the liver circadian clock is associated with several liver-related diseases, including nonalcoholic fatty liver disease, type 2 diabetes mellitus and hepatocellular carcinoma. A wide variety of liver functions are regulated daily by the liver circadian clock and via systemic circadian control by other organs and cells within the gastrointestinal tract as well as the microbiome and immune cells. Disruption of the circadian system, as occurs during jetlag, shift work or an unhealthy lifestyle, is implicated in several liver-related pathologies, ranging from metabolic diseases such as obesity, type 2 diabetes mellitus and nonalcoholic fatty liver disease to liver malignancies such as hepatocellular carcinoma. In this Review, we cover the molecular, cellular and organismal aspects of various liver pathologies from a circadian viewpoint, and in particular how circadian dysregulation has a role in the development and progression of these diseases. Finally, we discuss therapeutic and lifestyle interventions that carry health benefits through support of a functional circadian clock that acts in synchrony with the environment.
引用
收藏
页码：695 / 707
页数：13
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