Tumor immune evasion through loss of MHC class-I antigen presentation

被引：32

作者：

Sari, Gulce ^{[1
]}

Rock, Kenneth ^{[1
]}

机构：

[1] Univ Massachusetts, Med Sch, Dept Pathol, Worcester, MA 01605 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2023年 / 83卷

关键词：

IFN-GAMMA; CANCER; THERAPY; ESCAPE;

D O I：

10.1016/j.coi.2023.102329

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD8 T cells recognize cancers when they detect antigenic peptides presented on a tumor's surface MHC-I molecules. Since MHC-I antigen presentation is not essential for cell growth or survival, many cancers inactivate this pathway, and thereby escape control by CD8 T cells. Such immune evasion allows cancers to progress and also become resistant to CD8 T-cell-based immunotherapies, such as checkpoint blockade. Here, we review recent findings about the various different mechanisms that cancers use to impair antigen presentation, the consequence of such changes, and, in some cases, the potential to reverse these defects.

引用

页数：7

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