The second nationwide surveillance of antibacterial susceptibility patterns of pathogens isolated from skin and soft-tissue infections in dermatology departments in Japan

被引：1

作者：

Ohnishi, Takamitsu ^{[1
,2
,3
,4
,5
]}

Watanabe, Shinichi ^{[1
,2
,3
,4
,5
]}

Matsumoto, Tetsuya ^{[2
,3
,4
]}

Yotsuyanagi, Hiroshi ^{[2
,3
,4
]}

Sato, Junko ^{[2
,3
,4
]}

Kobayashi, Intestu ^{[6
]}

Iinuma, Shin ^{[7
]}

Nagayama, Takashi ^{[8
]}

Shibuya, Shuichiro ^{[9
]}

Ogawa, Natsuki ^{[10
]}

Iozumi, Ken ^{[11
]}

Nakajima, Yasuyuki ^{[12
]}

Kurikawa, Yukiko ^{[13
]}

Kobayashi, Motoko ^{[14
]}

Matsuo, Koma ^{[15
]}

Ishikawa, Hideyuki ^{[16
]}

Shimizu, Tadamichi ^{[17
]}

Tsutsui, Kiyohiro ^{[18
]}

Kawamura, Tatsuyoshi ^{[19
]}

Okuyama, Ryuhei ^{[20
]}

Seishima, Mariko ^{[21
]}

Akita, Yoichi ^{[22
]}

Kasugai, Chikatoshi ^{[23
]}

Yano, Katsuaki ^{[24
]}

Tamada, Yasuhiko ^{[25
]}

Mizutani, Kimihiko ^{[26
]}

Kabashima, Kenji ^{[27
]}

Yamada, Nanako ^{[28
]}

Ikeda, Masami ^{[29
]}

机构：

[1] Japanese Soc Chemotherapy, Dermatol Subcomm, Tokyo, Japan

[2] Japanese Soc Chemotherapy, Surveillance Comm, Tokyo, Japan

[3] Japanese Assoc Infect Dis, Tokyo, Japan

[4] Japanese Soc Clin Microbiol, Tokyo, Japan

[5] Teikyo Univ, Dept Dermatol, Sch Med, Tokyo, Japan

[6] Toho Univ, Fac Nursing, Dept Infect Control & Prevent, Tokyo, Japan

[7] Asahikawa Med Univ, Dept Dermatol, Asahikawa, Hokkaido, Japan

[8] Nagayama Dermatol Clin, Ibaraki, Japan

[9] Honjo Dermatol Clin, Saitama, Japan

[10] Fujimino Dermatol Clin, Saitama, Japan

[11] Tokyo Metropolitan Police Hosp, Dept Dermatol, Tokyo, Japan

[12] Nishidai Clover Dermatol Clin, Tokyo, Japan

[13] Zoushiki Dermatol Clin, Tokyo, Japan

[14] Kobayashi Dermatol Clin, Tokyo, Japan

[15] Nakano Dermatol Clin, Tokyo, Japan

[16] Yokohama City Univ, Dept Environm ImmunoDermatol, Grad Sch Med, Yokohama, Kanagawa, Japan

[17] Univ Toyama, Fac Med & Acad Assembly, Dept Dermatol, Toyama, Japan

[18] Ishikawa Prefectural Cent Hosp, Dept Dermatol, Kanazawa, Ishikawa, Japan

[19] Univ Yamanashi, Dept Dermatol, Fac Med, Yamanashi, Japan

[20] Shinshu Univ, Dept Dermatol, Sch Med, Matsumoto, Nagano, Japan

[21] Gifu Univ, Dept Dermatol, Grad Sch Med, Gifu, Japan

[22] Koyo Dermatol Clin, Nagoya, Aichi, Japan

[23] Kasugai Skin Clin, Kasugai, Aichi, Japan

[24] Chayagasaka Skin Clin, Nagoya, Aichi, Japan

[25] Tamada Skin Clin, Nagoya, Aichi, Japan

[26] Mizutani Dermatol Clin, Inazawa, Aichi, Japan

[27] Kyoto Univ, Grad Sch Med, Dept Dermatol, Kyoto, Japan

[28] Tottori Univ Hosp, Dept Dermatol, Tottori, Japan

[29] Takamatsu Red Cross Hosp, Dept Dermatol, Takamatsu, Kagawa, Japan

来源：

JOURNAL OF INFECTION AND CHEMOTHERAPY | 2023年 / 29卷 / 02期

关键词：

Surveillance; Susceptibility; Skin and soft-tissue infection SSTI; Methicillin-resistant S; aureus MRSA; Community-associated MRSA;

D O I：

10.1016/j.jiac.2022.10.005

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The present study compared trends in antimicrobial resistance patterns in pathogens isolated from skin and soft -tissue infections (SSTIs) in Japan with those of a nationwide survey conducted in 2013. Three organisms that caused most of the SSTIs were collected from 12 dermatology departments in medical centers and 12 derma-tology clinics across Japan between April 2019 and August 2020. A total of 390 strains, including 267 Staphy-lococcus aureus, 109 coagulase-negative staphylococci (CNS), and 14 Streptococcus pyogenes strains were submitted to a central laboratory for antimicrobial susceptibility testing. Patient demographic and clinical in-formation was collated.Methicillin-resistant S. aureus (MRSA) was detected in 25.8% (69/267) of the S. aureus strains. The prevalence of MRSA between the present study and the 2013 survey did not differ significantly. Furthermore, there were no significant differences in MIC values and susceptibility patterns of the MRSA strains to other agents, regardless of a history of hospitalization within 1 year or invasive medical procedures.Methicillin-resistant CNS (MRCNS) was detected in 48.6% (53/109) of CNS isolates, higher than the 35.4% prevalence in the 2013 survey. This difference could be attributed to the heterogeneity in the members of the MRCNS, which comprises multiple staphylococci species, between the 2013 and 2019 surveys. However, it was noted that the susceptibility profiles of the MRCNS to each antibiotic were not significantly different from those identified in the 2013 survey. Most strains of S. pyogenes were susceptible to each antibiotic, similar to the 2013 survey.Continuous monitoring of trends in pathogen and susceptibility profiles is important to advise local public health efforts regarding the appropriate treatment of SSTIs.

引用

页码：143 / 149

页数：7

共 7 条

[1]

Clinical and Laboratory Standards Institute, 2012, M100S22 CLSI

[2] Molecular characteristics of methicillin-resistant Staphylococcus aureus isolated from skin and soft tissue infections collected in the Japanese nationwide surveillance [J].

Kaku, Norihito ;

Ohnishi, Takamitsu ;

Matsumoto, Tetsuya ;

Watanabe, Shinichi ;

Yanagihara, Katsunori .

JOURNAL OF DERMATOLOGY, 2019, 46 (12) :1205-1209

[3] Investigation of the freely available easy-to-use software 'EZR' for medical statistics [J].

Kanda, Y. .

BONE MARROW TRANSPLANTATION, 2013, 48 (03) :452-458

[4] Molecular epidemiology and antimicrobial susceptibilities of 273 exfollative toxin-encoding-gene-positive Staphylococcus aureus isolates from patients with impetigo in Japan [J].

Nakaminami, Hidemasa ;

Noguchi, Norihisa ;

Ikeda, Masami ;

Hasui, Mikiko ;

Sato, Minoru ;

Yamamoto, Shinji ;

Yoshida, Tomoko ;

Asano, Takashi ;

Senoue, Mitsura ;

Sasatsu, Masanori .

JOURNAL OF MEDICAL MICROBIOLOGY, 2008, 57 (10) :1251-1258

[5]

Nishijima Setsuko, 1994, Journal of Dermatology (Tokyo), V21, P233

[6] The first nationwide surveillance of antibacterial susceptibility patterns of pathogens isolated from skin and soft-tissue infections in dermatology departments in Japan [J].

Watanabe, Shinichi ;

Ohnishi, Takamitsu ;

Yuasa, Akira ;

Kiyota, Hiroshi ;

Iwata, Satoshi ;

Kaku, Mitsuo ;

Watanabe, Akira ;

Sato, Junko ;

Hanaki, Hideaki ;

Manabe, Motomu ;

Suzuki, Tamio ;

Otsuka, Fujio ;

Aihara, Michiko ;

Iozumi, Ken ;

Tamaki, Takeshi ;

Funada, Yuichi ;

Shinozaki, Mikio ;

Kobayashi, Motoko ;

Okuda, Masaru ;

Kikyo, Go ;

Kikuchi, Kumi ;

Okada, Yoshitane ;

Takeshima, Masanori ;

Kaneko, Osamu ;

Ogawa, Natsuki ;

Ito, Rie ;

Okuyama, Ryuhei ;

Shimada, Shinji ;

Shimizu, Tadamichi ;

Hatta, Naohito ;

Manabu, Maeda ;

Tsutsui, Kiyohiro ;

Tanaka, Toshihiro ;

Miyachi, Yoshiki ;

Asada, Hideo ;

Furukawa, Fukumi ;

Kurokawa, Ichiro ;

Iwatsuki, Keiji ;

Hide, Michihiro ;

Muto, Masahiko ;

Yamamoto, Osamu ;

Niihara, Hiroyuki ;

Takagaki, Kenji ;

Kubota, Yasuo ;

Sayama, Koji ;

Sano, Shigetoshi ;

Furue, Masutaka ;

Kanekura, Takuro .

JOURNAL OF INFECTION AND CHEMOTHERAPY, 2017, 23 (08) :503-511

[7] Antimicrobial susceptibility and molecular characteristics of 857 methicillin-resistant Staphylococcus aureus isolates from 16 medical centers in Japan (2008-2009): nationwide survey of community-acquired and nosocomial MRSA [J].

Yanagihara, Katsunori ;

Araki, Nobuko ;

Watanabe, Shinichi ;

Kinebuchi, Takahiro ;

Kaku, Mitsuo ;

Maesaki, Shigefumi ;

Yamaguchi, Keizo ;

Matsumoto, Tetsuya ;

Mikamo, Hiroshige ;

Takesue, Yoshio ;

Kadota, Jun-Ichi ;

Fujita, Jiro ;

Iwatsuki, Keiji ;

Hino, Haruko ;

Kaneko, Takehiko ;

Asagoe, Kenji ;

Ikeda, Masami ;

Yasuoka, Akira ;

Kohno, Shigeru .

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2012, 72 (03) :253-257

← 1 →