Sensitive biosensors based on topological insulator Bi2Se3 and peptide

被引：14

作者：

Jiang, Yujiu ^{[1
,2
,3
]}

Zhu, Peng ^{[1
,2
,3
]}

Zhao, Jinge ^{[4
]}

Li, Shanshan ^{[5
]}

Wu, Yetong ^{[1
,2
,3
]}

Xiong, Xiaolu ^{[1
,2
,3
]}

Zhang, Xu ^{[1
,2
,3
]}

Liu, Yuxiang ^{[1
,2
,3
]}

Bai, Jiangyue ^{[1
,2
,3
]}

Wang, Zihang ^{[1
,2
,3
]}

Xu, Shiqi ^{[1
,2
,3
]}

Wang, Minxuan ^{[4
]}

Song, Tinglu ^{[6
]}

Wang, Zhiwei ^{[1
,2
,3
]}

Wang, Weizhi ^{[4
]}

Han, Junfeng ^{[1
,2
,3
]}

机构：

[1] Beijing Inst Technol, Ctr Quantum Phys, Sch Phys, Key Lab Adv Optoelect Quantum Architecture & Measu, Beijing 100081, Peoples R China

[2] Beijing Inst Technol, Yangtze Delta Reg Acad, Jiaxing 314019, Peoples R China

[3] Beijing Inst Technol, Sch Phys, Beijing Key Lab Nanophoton & Ultrafine Optoelect S, Beijing 100081, Peoples R China

[4] Beijing Inst Technol, Sch Chem & Chem Engn, Key Lab Med Mol Sci & Pharmaceut Engn,Minist Educ,, Key Lab Cluster Sci Minist Educ,Minist Ind & Infor, Beijing 100081, Peoples R China

[5] China Japan Friendship Hosp, Dept Rheumatol, Beijing 100029, Peoples R China

[6] Beijing Inst Technol, Expt Ctr Adv Mat Sch Mat Sci & Engn, Beijing 100081, Peoples R China

来源：

ANALYTICA CHIMICA ACTA | 2023年 / 1239卷

基金：

中国国家自然科学基金; 北京市自然科学基金;

关键词：

Programmed death-ligand 1; Anti-HA Tag antibody; Topological insulator; Bi2Se3; Electrochemical biosensor; CANCER BIOMARKER; GRAPHENE OXIDE; DEHYDROGENASE; PD-L1;

D O I：

10.1016/j.aca.2022.340655

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

In this work, we designed a facile and label-free electrochemical biosensor based on intrinsic topological insu-lator (TI) Bi2Se3 and peptide for the detection of immune checkpoint molecules. With topological protection, Bi2Se3 could have robust surface states with low electronic noise, which was beneficial for the stable and sen-sitive electron transport between electrode and electrolyte interface. The peptides are easily synthesized and chemically modified, and have good biocompatibility and bioavailability, which is a suitable candidate as the recognition units for immune checkpoint molecules. Therefore, the peptide/Bi2Se3 was developed as a suitable working electrode for the electrochemical biosensor. The basic performance of the designed peptide/Bi2Se3 biosensor was investigated to determine the Anti-HA Tag Antibody and PD-L1 molecules. The linear detection range was from 3.6 x 10-10 mg mL-1 to 3.6 x 10-5 mg mL-1, and the detection limit was 1.07 x 10-11 mg mL-1. Moreover, the biosensor also displayed good selectivity and stability.

引用

页数：8

共 48 条

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