Titanium surface polyethylene glycol hydrogel and gentamicin-loaded cross-linked starch microspheres release system for anti-infective drugs

被引：4

作者：

Wu, Yunfeng ^{[1
,2
]}

Hu, Fanqi ^{[2
]}

Yang, Xiaoqing ^{[2
]}

Zhang, Shaofu ^{[2
]}

Jia, Chengqi ^{[1
]}

Liu, Xiaole ^{[1
]}

Zhang, Xuesong ^{[2
]}

机构：

[1] Med Sch Chinese PLA, 28 Fuxing Rd, Beijing 100853, Peoples R China

[2] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 8, Dept Orthoped, Beijing, Peoples R China

来源：

JOURNAL OF DRUG TARGETING | 2023年 / 31卷 / 02期

关键词：

Titanium; gentamicin; hydrogel drug release system; antibacterial; PEG; BIOCOMPATIBILITY;

D O I：

10.1080/1061186X.2022.2134395

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Objective: To design and construct a hydrogel drug-controlled release system loaded with gentamicin on a titanium surface, and to evaluate the in vitro drug release behaviour and antibacterial properties and biocompatibility of the controlled release system. Methods: Titanium (Ti) surface was coated with poly dopamine (PDA) substrate, and then polyethylene glycol (PEG) was attached to PDA. The composite drug microsphere controlled release layer formed by gentamicin (GEN) and cross-linked starch (CSt) were subsequently covered with poly lactic-o-glycolic acid (PLGA) as a barrier to construct a Ti-GEN-Cst-PLGA anti-infective drug controlled release system. Results: The hydrogel drug release system was successfully constructed. The results of in vitro anti-staphylococcus aureus (SAU) assay, anti-staphylococcus epidermidis (SEP) assay and anti-Escherichia coli (ECO) assay showed that Ti-GEN-Cst-PLGA could effectively inhibit the growth of three bacteria. Assay in the New Zealand rabbit found that Ti-GEN- Cst-PLGA could promote wound healing at the 3rd week after implantation, and the pathology assay found that the Ti-GEN-Cst-PLGA group had less inflammatory reactions and significant tissue proliferation at the endophyte contact surface. Conclusion: Ti-GEN-Cst-PLGA can effectively inhibit the inflammatory response and promote wound healing, or may be a potential treatment for orthopaedic endophytes.

引用

页码：217 / 224

页数：8