Outbreak of Oropouche virus in frontier regions in western Amazon

被引:17
作者
Moreira, Hillquias Monteiro [1 ,2 ,3 ]
Sgorlon, Gabriella [1 ,2 ,3 ]
Queiroz, Jackson A. S. [1 ,2 ,3 ]
Roca, Tarcio P. [1 ,3 ]
Ribeiro, Jessiane [1 ,3 ]
Teixeira, Karolaine S. [1 ,3 ]
Passos-Silva, Ana Maisa [1 ,2 ,3 ]
Araujo, Adrhyan [1 ,3 ]
Gasparelo, Nadson Willian Felipe [1 ,2 ,3 ]
Dos Santos, Alcione de Oliveira [4 ]
Lugtenburg, Celina Aparecida Bertoni [4 ]
Roque, Rosemary Aparecida [5 ]
Villalobos Salcedo, Juan Miguel [3 ]
Pereira, Dhelio B. [3 ]
Vieira, Deusilene [1 ,2 ,3 ]
机构
[1] Fundacao Oswaldo Cruz Rondonia, Lab Virol Mol, FIOCRUZ, RO, Porto Velho, Rondonia, Brazil
[2] Univ Fed Rondonia, Programa Pos Graduacao Biol Expt, UNIR, Porto Velho, Rondonia, Brazil
[3] CEPEM, Ctr Pesquisa Med Trop, Porto Velho, Rondonia, Brazil
[4] Lab Cent Saude Publ Rondonia, LACEN, RO, Porto Velho, Rondonia, Brazil
[5] INPA, Inst Nacl Pesquisas Amazonia, Manaus, Amazonas, Brazil
来源
MICROBIOLOGY SPECTRUM | 2024年 / 12卷 / 03期
关键词
Oropouche; OROV; epidemiology; genomic surveillance; phylogeny; ARBOVIRAL DISEASES; INFECTION; EPIDEMIOLOGY; TRANSMISSION; BRAZIL; FEVER;
D O I
10.1128/spectrum.01629-23
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Oropouche virus (OROV) is characterized as a re-emerging arbovirus of great concern for public health, being responsible for several outbreaks of acute fever identified in Latin American countries, registering more than half a million reported cases. The incidence of reports of this virus is intrinsically favored by environmental conditions, in which such characteristics are related to the increase and distribution of the vector population to areas of human traffic. Moreover, there is a problem regarding the lack of diagnosis in Brazil that aggregates the success of the etiologic agent. Thus, by means of molecular techniques, we identified 27 positive cases of the OROV circulating in border locations in western Amazon, with 44.44% (12/27) of the cohort characterized as infected individuals with reported symptoms, mainly ranging from fever, myalgia, and back pain. Among the positive samples, it was possible to obtain a total of 48.14% (13/27) samples to analyze the S and M segments of Oropouche, which showed similarities among the Brazilian sequences. Thus, it was possible to verify the circulation of the OROV in Rondonia and border areas, in which the tracking of neglected arboviruses is necessary for the genomic surveillance of emerging and re-emerging viruses.IMPORTANCEThe western Amazon region is known for outbreaks of acute febrile illnesses, to which the lack of specific diagnostics for different pathogens hinders the management of patients in healthcare units. The Oropouche virus has already been recorded in the region in the 1990s. However, this is the first study, after this record, to perform the detection of individuals with acute febrile illness using a screening test to exclude Zika, dengue, and chikungunya, confirmed by sequencing the circulation of the virus in the state of Rondonia and border areas. We emphasize the importance of including diagnostics for viruses such as Oropouche, which suffers underreporting for years and is related to seasonal periods in Western Amazon locations, a factor that has a direct influence on public health in the region. In addition, we emphasize the importance of genomic surveillance in the elucidation of outbreaks that affect the resident population of these locations. The western Amazon region is known for outbreaks of acute febrile illnesses, to which the lack of specific diagnostics for different pathogens hinders the management of patients in healthcare units. The Oropouche virus has already been recorded in the region in the 1990s. However, this is the first study, after this record, to perform the detection of individuals with acute febrile illness using a screening test to exclude Zika, dengue, and chikungunya, confirmed by sequencing the circulation of the virus in the state of Rondonia and border areas. We emphasize the importance of including diagnostics for viruses such as Oropouche, which suffers underreporting for years and is related to seasonal periods in Western Amazon locations, a factor that has a direct influence on public health in the region. In addition, we emphasize the importance of genomic surveillance in the elucidation of outbreaks that affect the resident population of these locations.
引用
收藏
页数:12
相关论文
共 52 条
  • [21] Evidence of Oropouche Orthobunyavirus Infection, Colombia, 2017
    Gomez-Camargo, Doris E.
    Egurrola-Pedraza, Jorge A.
    Cruz, Cristopher D.
    Popuche, Dina
    Ochoa-Diaz, Margarita M.
    Guevara, Carolina
    Silva, Maria
    Abente, Eugenio J.
    Ampuero, Julia S.
    [J]. EMERGING INFECTIOUS DISEASES, 2021, 27 (06) : 1756 - 1758
  • [22] Emerging arboviruses: Why today?
    Gould, Ernest
    Pettersson, John
    Higgs, Stephen
    Charrel, Remi
    de Lamballerie, Xavier
    [J]. ONE HEALTH, 2017, 4 : 1 - 13
  • [23] The global emergence/resurgence of arboviral diseases as public health problems
    Gubler, DJ
    [J]. ARCHIVES OF MEDICAL RESEARCH, 2002, 33 (04) : 330 - 342
  • [24] ictv.global, Current ICTV Taxonomy Release|ICTV
  • [25] IPAM Amazonia, AMAZ NIA CHAMAS 9 NO
  • [26] Toxoplasma gondii Infection in the United States, 2011-2014
    Jones, Jeffrey L.
    Kruszon-Moran, Deanna
    Elder, Scott
    Rivera, Hilda N.
    Press, Cindy
    Montoya, Jose G.
    McQuillan, Geraldine M.
    [J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2018, 98 (02) : 551 - 557
  • [27] Mayaro virus detection in the western region of Para state, Brazil
    Junior Saatkamp, Cassiano
    Ribeiro Rodrigues, Luis Reginaldo
    Nogueira Pereira, Andrew Mairom
    Coelho, Joao Alberto
    Brito Marques, Rose Grace
    de Souza, Victor Costa
    do Nascimento, Valdinete Alves
    dos Santos Saatkamp, Jamille Gomes
    Naveca, Felipe Gomes
    Pinto de Figueiredo, Regina Maria
    [J]. REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 2021, 54
  • [28] Drivers, dynamics, and control of emerging vector-borne zoonotic diseases
    Kilpatrick, A. Marm
    Randolph, Sarah E.
    [J]. LANCET, 2012, 380 (9857) : 1946 - 1955
  • [29] Factors responsible for the emergence of arboviruses; strategies, challenges and limitations for their control
    Liang, Guodong
    Gao, Xiaoyan
    Gould, Ernest A.
    [J]. EMERGING MICROBES & INFECTIONS, 2015, 4
  • [30] Culicoides biting midges: Their role as arbovirus vectors
    Mellor, PS
    Boorman, J
    Baylis, M
    [J]. ANNUAL REVIEW OF ENTOMOLOGY, 2000, 45 : 307 - 340