The dual role of microglia in neuropathic pain after spinal cord injury: Detrimental and protective effects

被引：26

作者：

Sun, Chang ^{[1
,2
,3
]}

Deng, Junhao ^{[1
,2
,4
,5
,6
]}

Ma, Yifei ^{[7
]}

Meng, Fanqi ^{[8
]}

Cui, Xiang ^{[1
,2
]}

Li, Ming ^{[1
,2
]}

Li, Jiantao ^{[1
,2
]}

Li, Jia ^{[1
,2
]}

Yin, Pengbin ^{[1
,2
]}

Kong, Lingjie ^{[5
,6
]}

Zhang, Licheng ^{[1
,2
]}

Tang, Peifu ^{[1
,2
]}

机构：

[1] Chinese Peoples Liberat Army Gen Hosp, Dept Orthoped, Med Ctr 4, Beijing, Peoples R China

[2] Natl Clin Res Ctr Orthoped Sports Med & Rehabil, Beijing, Peoples R China

[3] AF Med Ctr, Dept Orthoped, PLA, Beijing, Peoples R China

[4] Tsinghua Univ, Sch Life Sci, Beijing, Peoples R China

[5] Tsinghua Univ, Dept Precis Instruments, State Key Lab Precis Measurement Technol & Instrum, Beijing, Peoples R China

[6] Tsinghua Univ, IDG McGovern Inst Brain Res, Beijing, Peoples R China

[7] Nankai Univ, Sch Med, Tianjin, Peoples R China

[8] Capital Med Univ, Xuanwu Hosp, Dept Anesthesiol, Beijing, Peoples R China

来源：

EXPERIMENTAL NEUROLOGY | 2023年 / 370卷

基金：

中国国家自然科学基金;

关键词：

Spinal cord injury; Neuropathic pain; Microglia; Central nervous system; PERIPHERAL-NERVE INJURY; LONG-TERM POTENTIATION; DORSAL-HORN; CENTRAL SENSITIZATION; MECHANICAL ALLODYNIA; PERSISTENT PAIN; CONTRIBUTES; ACTIVATION; MACROPHAGES; BRAIN;

D O I：

10.1016/j.expneurol.2023.114570

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Spinal cord injury (SCI) is a debilitating condition that is frequently accompanied by neuropathic pain, resulting in significant physical and psychological harm to a vast number of individuals globally. Despite the high prevalence of neuropathic pain following SCI, the precise underlying mechanism remains incompletely understood. Microglia are a type of innate immune cell that are present in the central nervous system (CNS). They have been observed to have a significant impact on neuropathic pain following SCI. This article presents a comprehensive overview of recent advances in understanding the role of microglia in the development of neuropathic pain following SCI. Specifically, the article delves into the detrimental and protective effects of microglia on neuropathic pain following SCI, as well as the mechanisms underlying their interconversion. Furthermore, the article provides a thorough overview of potential avenues for future research in this area.

引用

页数：11

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