Structural and Synthetic Aspects of Small Ring Oxa- and Aza-Heterocyclic Ring Systems as Antiviral Activities

被引：1

作者：

Manna, Sibasish ^{[1
]}

Das, Koushik ^{[1
]}

Santra, Sougata ^{[2
]}

Nosova, Emily V. ^{[2
,3
]}

Zyryanov, Grigory V. ^{[2
,3
]}

Halder, Sandipan ^{[1
]}

机构：

[1] Visvesvaraya Natl Inst Technol, Dept Chem, Nagpur 440010, India

[2] Ural Fed Univ, Chem Engn Inst, Dept Organ & Biomol Chem, 19 Mira St, Ekaterinburg 620002, Russia

[3] Russian Acad Sci, Ural Div, I Ya Postovskiy Inst Organ Synth, 22 S Kovalevskoy St, Ekaterinburg 620219, Russia

来源：

VIRUSES-BASEL | 2023年 / 15卷 / 09期

关键词：

antiviral agents; heterocycles; natural products; Structure Activity Relationship (SAR); synthetic methods; HEPATITIS-B-VIRUS; HIV-1 PROTEASE INHIBITORS; SMALL-MOLECULE INHIBITORS; ACID SYNTHASE INHIBITORS; EBOLA-VIRUS; ZIKA VIRUS; ANTI-HIV; PHYSICOCHEMICAL PROPERTIES; BIOLOGICAL EVALUATION; ORAL GANCICLOVIR;

D O I：

10.3390/v15091826

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Antiviral properties of different oxa- and aza-heterocycles are identified and properly correlated with their structural features and discussed in this review article. The primary objective is to explore the activity of such ring systems as antiviral agents, as well as their synthetic routes and biological significance. Eventually, the structure-activity relationship (SAR) of the heterocyclic compounds, along with their salient characteristics are exhibited to build a suitable platform for medicinal chemists and biotechnologists. The synergistic conclusions are extremely important for the introduction of a newer tool for the future drug discovery program.

引用

页数：57

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