Emerging Immunotherapy Approaches for Treating Prostate Cancer
被引:11
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作者:
Meng, Lingbin
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机构:
Ohio State Univ, Comprehens Canc Ctr, Dept Internal Med, Div Med Oncol, Columbus, OH 43210 USAOhio State Univ, Comprehens Canc Ctr, Dept Internal Med, Div Med Oncol, Columbus, OH 43210 USA
Meng, Lingbin
[1
]
Yang, Yuanquan
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机构:
Ohio State Univ, Comprehens Canc Ctr, Dept Internal Med, Div Med Oncol, Columbus, OH 43210 USAOhio State Univ, Comprehens Canc Ctr, Dept Internal Med, Div Med Oncol, Columbus, OH 43210 USA
Yang, Yuanquan
[1
]
Mortazavi, Amir
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机构:
Ohio State Univ, Comprehens Canc Ctr, Dept Internal Med, Div Med Oncol, Columbus, OH 43210 USAOhio State Univ, Comprehens Canc Ctr, Dept Internal Med, Div Med Oncol, Columbus, OH 43210 USA
Mortazavi, Amir
[1
]
Zhang, Jingsong
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机构:
Univ S Florida, H Lee Moffitt Canc Ctr & Res Inst, Dept Genitourinary Oncol, 12902 USF Magnolia Dr, Tampa, FL 33612 USAOhio State Univ, Comprehens Canc Ctr, Dept Internal Med, Div Med Oncol, Columbus, OH 43210 USA
Zhang, Jingsong
[2
]
机构:
[1] Ohio State Univ, Comprehens Canc Ctr, Dept Internal Med, Div Med Oncol, Columbus, OH 43210 USA
[2] Univ S Florida, H Lee Moffitt Canc Ctr & Res Inst, Dept Genitourinary Oncol, 12902 USF Magnolia Dr, Tampa, FL 33612 USA
immunotherapy;
prostate cancer;
immune checkpoint inhibitors;
bispecific antibodies;
CAR T cells;
vaccines;
cytokines;
immunotherapeutic combinations;
CAR-T-CELLS;
IMMUNE-CHECKPOINT;
DOUBLE-BLIND;
PHASE-III;
PLUS DOCETAXEL;
CLINICAL-TRIAL;
SIPULEUCEL-T;
TUMOR MICROENVIRONMENT;
DNA VACCINE;
ANTIGEN;
D O I:
10.3390/ijms241814347
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Immunotherapy has emerged as an important approach for cancer treatment, but its clinical efficacy has been limited in prostate cancer compared to other malignancies. This review summarizes key immunotherapy strategies under evaluation for prostate cancer, including immune checkpoint inhibitors, bispecific T cell-engaging antibodies, chimeric antigen receptor (CAR) T cells, therapeutic vaccines, and cytokines. For each modality, the rationale stemming from preclinical studies is discussed along with outcomes from completed clinical trials and strategies to improve clinical efficacy that are being tested in ongoing clinical trials. Imperative endeavors include biomarker discovery for patient selection, deciphering resistance mechanisms, refining cellular therapies such as CAR T cells, and early-stage intervention were reviewed. These ongoing efforts instill optimism that immunotherapy may eventually deliver significant clinical benefits and expand treatment options for patients with advanced prostate cancer.
机构:
Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu 610041, Peoples R ChinaSichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu 610041, Peoples R China
Chen, Jie
Ma, Na
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机构:
Sichuan Univ, West China Univ Hosp 2, Dept Pediat, 20,3rd Sect,South Renmin Rd, Chengdu 610041, Peoples R ChinaSichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu 610041, Peoples R China
Ma, Na
Chen, Bo
论文数: 0引用数: 0
h-index: 0
机构:
Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu 610041, Peoples R ChinaSichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu 610041, Peoples R China
Chen, Bo
Huang, Yin
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机构:
Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu 610041, Peoples R ChinaSichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu 610041, Peoples R China
Huang, Yin
Li, Jinze
论文数: 0引用数: 0
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机构:
Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu 610041, Peoples R ChinaSichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu 610041, Peoples R China
Li, Jinze
Li, Jin
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机构:
Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu 610041, Peoples R ChinaSichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu 610041, Peoples R China
Li, Jin
Chen, Zeyu
论文数: 0引用数: 0
h-index: 0
机构:
Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu 610041, Peoples R ChinaSichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu 610041, Peoples R China
Chen, Zeyu
Wang, Puze
论文数: 0引用数: 0
h-index: 0
机构:
Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu 610041, Peoples R ChinaSichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu 610041, Peoples R China
Wang, Puze
Ran, Biao
论文数: 0引用数: 0
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机构:
Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu 610041, Peoples R ChinaSichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu 610041, Peoples R China
Ran, Biao
Yang, Jiahao
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机构:
Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu 610041, Peoples R ChinaSichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu 610041, Peoples R China
Yang, Jiahao
Bai, Jingxing
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机构:
Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu 610041, Peoples R ChinaSichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu 610041, Peoples R China
Bai, Jingxing
Ning, Shu
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机构:
Univ Calif Davis, Dept Urol Surg, Davis, CA USASichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu 610041, Peoples R China
Ning, Shu
Ai, Jianzhong
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机构:
Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu 610041, Peoples R ChinaSichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu 610041, Peoples R China
Ai, Jianzhong
Wei, Qiang
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机构:
Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu 610041, Peoples R ChinaSichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu 610041, Peoples R China
Wei, Qiang
Liu, Liangren
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机构:
Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu 610041, Peoples R ChinaSichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu 610041, Peoples R China
Liu, Liangren
Cao, Dehong
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机构:
Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu 610041, Peoples R ChinaSichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu 610041, Peoples R China
机构:
Icahn Sch Med Mt Sinai, Dept Urol, New York, NY 10029 USA
Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 USAIcahn Sch Med Mt Sinai, Dept Urol, New York, NY 10029 USA
Chakravarty, Dimple
Huang, Li
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机构:
Icahn Sch Med Mt Sinai, Dept Urol, New York, NY 10029 USA
Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Urol, Guangzhou, Peoples R ChinaIcahn Sch Med Mt Sinai, Dept Urol, New York, NY 10029 USA
Huang, Li
Kahn, Matthew
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Icahn Sch Med Mt Sinai, Dept Urol, New York, NY 10029 USAIcahn Sch Med Mt Sinai, Dept Urol, New York, NY 10029 USA
Kahn, Matthew
Tewari, Ashutosh K.
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Icahn Sch Med Mt Sinai, Dept Urol, New York, NY 10029 USA
Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 USAIcahn Sch Med Mt Sinai, Dept Urol, New York, NY 10029 USA
机构:
Icahn Sch Med Mt Sinai, Tisch Canc Inst, Div Hematol & Oncol, Dept Med, New York, NY 10010 USAIcahn Sch Med Mt Sinai, Tisch Canc Inst, Div Hematol & Oncol, Dept Med, New York, NY 10010 USA
Patel, Vaibhav G.
Oh, William K.
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Icahn Sch Med Mt Sinai, Tisch Canc Inst, Div Hematol & Oncol, Dept Med, New York, NY 10010 USAIcahn Sch Med Mt Sinai, Tisch Canc Inst, Div Hematol & Oncol, Dept Med, New York, NY 10010 USA
机构:
Pharma Mar SA, Madrid, SpainPharma Mar SA, Madrid, Spain
Fernandez-Garcia, E. M.
Vera-Badillo, F. E.
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Univ Hlth Network, Princess Margaret Hosp, Dept Med Oncol & Hematol, Toronto, ON M5G 2M9, CanadaPharma Mar SA, Madrid, Spain
Vera-Badillo, F. E.
Perez-Valderrama, B.
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Univ Hosp Virgen del Rocio, Dept Med Oncol, Seville 41013, SpainPharma Mar SA, Madrid, Spain
Perez-Valderrama, B.
Matos-Pita, A. S.
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Pharma Mar SA, Madrid, SpainPharma Mar SA, Madrid, Spain
Matos-Pita, A. S.
Duran, I.
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机构:
Univ Hlth Network, Princess Margaret Hosp, Dept Med Oncol & Hematol, Toronto, ON M5G 2M9, Canada
Univ Hosp Virgen del Rocio, Dept Med Oncol, Seville 41013, SpainPharma Mar SA, Madrid, Spain
机构:
Ist Sci Romagnolo Studio & Cura Tumori IRST IRCCS, Dept Med Oncol, Via P Maroncelli 40, I-47014 Meldola, ItalyIst Sci Romagnolo Studio & Cura Tumori IRST IRCCS, Dept Med Oncol, Via P Maroncelli 40, I-47014 Meldola, Italy
Schepisi, Giuseppe
Farolfi, Alberto
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Ist Sci Romagnolo Studio & Cura Tumori IRST IRCCS, Dept Med Oncol, Via P Maroncelli 40, I-47014 Meldola, ItalyIst Sci Romagnolo Studio & Cura Tumori IRST IRCCS, Dept Med Oncol, Via P Maroncelli 40, I-47014 Meldola, Italy
Farolfi, Alberto
Conteduca, Vincenza
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Ist Sci Romagnolo Studio & Cura Tumori IRST IRCCS, Dept Med Oncol, Via P Maroncelli 40, I-47014 Meldola, ItalyIst Sci Romagnolo Studio & Cura Tumori IRST IRCCS, Dept Med Oncol, Via P Maroncelli 40, I-47014 Meldola, Italy
Conteduca, Vincenza
Martignano, Filippo
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Ist Sci Romagnolo Studio & Cura Tumori IRST IRCCS, Biosci Lab, Via P Maroncelli 40, I-47014 Meldola, ItalyIst Sci Romagnolo Studio & Cura Tumori IRST IRCCS, Dept Med Oncol, Via P Maroncelli 40, I-47014 Meldola, Italy
Martignano, Filippo
De Lisi, Delia
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Campus Biomed Univ, Med Oncol Dept, Via Alvaro Portillo 200, I-00128 Rome, ItalyIst Sci Romagnolo Studio & Cura Tumori IRST IRCCS, Dept Med Oncol, Via P Maroncelli 40, I-47014 Meldola, Italy
De Lisi, Delia
Ravaglia, Giorgia
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Ist Sci Romagnolo Studio & Cura Tumori IRST IRCCS, Unit Biostat & Clin Trials, Via P Maroncelli 40, I-47014 Meldola, ItalyIst Sci Romagnolo Studio & Cura Tumori IRST IRCCS, Dept Med Oncol, Via P Maroncelli 40, I-47014 Meldola, Italy
Ravaglia, Giorgia
Rossi, Lorena
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Ist Sci Romagnolo Studio & Cura Tumori IRST IRCCS, Dept Med Oncol, Via P Maroncelli 40, I-47014 Meldola, ItalyIst Sci Romagnolo Studio & Cura Tumori IRST IRCCS, Dept Med Oncol, Via P Maroncelli 40, I-47014 Meldola, Italy
Rossi, Lorena
Menna, Cecilia
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Ist Sci Romagnolo Studio & Cura Tumori IRST IRCCS, Dept Med Oncol, Via P Maroncelli 40, I-47014 Meldola, ItalyIst Sci Romagnolo Studio & Cura Tumori IRST IRCCS, Dept Med Oncol, Via P Maroncelli 40, I-47014 Meldola, Italy
Menna, Cecilia
Bellia, Salvatore Roberto
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Ist Sci Romagnolo Studio & Cura Tumori IRST IRCCS, Radiotherapy Unit, Via P Maroncelli 40, I-47014 Meldola, ItalyIst Sci Romagnolo Studio & Cura Tumori IRST IRCCS, Dept Med Oncol, Via P Maroncelli 40, I-47014 Meldola, Italy
Bellia, Salvatore Roberto
Barone, Domenico
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Ist Sci Romagnolo Studio & Cura Tumori IRST IRCCS, Radiol Unit, Via P Maroncelli 40, I-47014 Meldola, ItalyIst Sci Romagnolo Studio & Cura Tumori IRST IRCCS, Dept Med Oncol, Via P Maroncelli 40, I-47014 Meldola, Italy
Barone, Domenico
Gunelli, Roberta
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Forli Hosp, Romagna Local Hlth Serv, Urol Unit, I-47100 Forli, ItalyIst Sci Romagnolo Studio & Cura Tumori IRST IRCCS, Dept Med Oncol, Via P Maroncelli 40, I-47014 Meldola, Italy
Gunelli, Roberta
De Giorgi, Ugo
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Ist Sci Romagnolo Studio & Cura Tumori IRST IRCCS, Dept Med Oncol, Via P Maroncelli 40, I-47014 Meldola, ItalyIst Sci Romagnolo Studio & Cura Tumori IRST IRCCS, Dept Med Oncol, Via P Maroncelli 40, I-47014 Meldola, Italy