Preoperative oral antibiotic administration in patients undergoing curative resection with stoma creation for colorectal cancer: effectiveness in preventing surgical site infection and the possibility of peristomal candidiasis induced by enterobacterial alteration

被引：1

作者：

Kiuchi, Jun ^{[1
,2
]}

Kuriu, Yoshiaki ^{[1
]}

Arita, Tomohiro ^{[1
]}

Shimizu, Hiroki ^{[1
]}

Nanishi, Kenji ^{[1
]}

Takaki, Wataru ^{[1
]}

Ohashi, Takuma ^{[1
]}

Konishi, Hirotaka ^{[1
]}

Yamamoto, Yusuke ^{[1
]}

Morimura, Ryo ^{[1
]}

Shiozaki, Atsuishi ^{[1
]}

Ikoma, Hisashi ^{[1
]}

Kubota, Takeshi ^{[1
]}

Fujiwara, Hitoshi ^{[1
]}

Otsuji, Eigo ^{[1
]}

机构：

[1] Kyoto Prefectural Univ Med, Dept Surg, Div Digest Surg, Kyoto, Japan

[2] Kyoto Prefectural Univ Med, Dept Surg, Div Digest Surg, 465 Kajii-cho Kawaramachihirokoji Kamigyo-ku, Kyoto 6028566, Japan

来源：

COLORECTAL DISEASE | 2023年 / 25卷 / 11期

关键词：

colorectal cancer; oral antibiotics; peristomal candidiasis; surgical site infection; MECHANICAL BOWEL PREPARATION; SURGERY; COLON; PROPHYLAXIS; ASSOCIATION; MULTICENTER; GUIDELINES; SOCIETY; SCORE; SKIN;

D O I：

10.1111/codi.16754

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AimThere are many reports that preoperative oral antibiotics (OAs) are effective in preventing surgical site infections (SSIs) in colorectal surgery. However, there is no consensus on the optimal dose of OAs. In this study, we investigated the efficacy of OAs in preventing SSIs and the possibility that OAs induce enterobacterial alteration in the intestinal tract.MethodWe performed a retrospective cross-sectional analysis of 389 patients who underwent R0 resection and stoma creation for colorectal cancer in our department between 2009 and 2020. We focused on the incidence of peristomal candidiasis (PSC) as an indicator of enterobacterial alteration and used kanamycin (KM) and metronidazole (MNZ) as the OAs. A low-dose group received 1000 mg/day of both KM and MNZ, and a high-dose group received 2000 mg/day of both KM and MNZ.ResultsSSI occurred in 60 of the 389 cases (15.4%). Regardless of stoma type, SSI was significantly more common in the non-OA group, while PSC was significantly less common. When examined by OA dose, the incidence of SSI was not significantly different between the low-dose and high-dose groups. However, PSC was significantly more common in the high-dose group than in the non-OA and low-dose groups. Analysis of bacterial and fungal levels in stool samples showed that bacterial levels after OAs were significantly lower than before OAs, while fungal levels increased.ConclusionOAs significantly reduce SSI in colorectal cancer surgery. However, excess OAs were significantly associated with the occurrence of PSC without contributing to further reduction in SSI.

引用

页码：2217 / 2224

页数：8

共 27 条

[1] Association of Duration and Type of Surgical Prophylaxis With Antimicrobial-Associated Adverse Events [J].