Genomic Characterization of a Novel HIV-1 Second-Generation Recombinant (CRF01_AE/CRF07_BC) Identified from a Men Who Have Sex with Men (MSM) Patient in Hebei, China

被引：0

作者：

Cai, Huixin ^{[1
]}

Du, Jian ^{[2
]}

Su, Miaomiao ^{[2
]}

Meng, Juan ^{[2
,4
]}

An, Weina ^{[3
]}

Shi, Haoxi ^{[3
]}

Fan, Weiguang ^{[3
]}

机构：

[1] Baoding 1 Cent Hosp, Clin Lab, Baoding, Peoples R China

[2] Peoples Hosp Baoding, Infect Div, Baoding, Peoples R China

[3] Peoples Hosp Baoding, Clin Lab, Baoding, Peoples R China

[4] Peoples Hosp Baoding, Infect Div, 608 Dongfeng East Rd, Baoding 071000, Hebei, Peoples R China

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2023年 / 39卷 / 10期

关键词：

HIV-1; near full-length genome; CRF01_AE; CRF07_BC; men who have sex with men;

D O I：

10.1089/aid.2023.0035

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Along with the co-circulation of dominant HIV-1 strains (CRF01_AE and CRF07_BC) in China, an increasing number of second-generation recombinants are being detected, especially among men who have sex with men (MSM). In this study, we identified a unique CRF01_AE/CRF07_BC recombinant from a HIV-1-positive man (BDD015A) infected through homosexual transmission in Baoding city, Hebei Province. Analysis of the near full-length genome sequence of the recombinant revealed five segments divided by four breakpoints, with two regions of CRF07_BC inserted into the pol and env regions of the CRF01_AE backbone. Three CRF01_AE segments (I, III, and V) clustered within the cluster 4 lineage, which mainly circulated among MSM in China. This recombinant differed from previously reported CRF01_ AE and CRF07_BC recombinant forms. The continuous emergence of novel recombinants increases the genetic complexity of HIV-1 in Hebei. Further measures are needed to monitor the molecular epidemiological characteristics of HIV-1 to help control the spread of infections.

引用

页码：575 / 580

页数：6

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