Novel Nanotechnological Strategies for Skin Anti-aging

被引：19
作者：
Pozos-Nonato, Sara [1 ]
Dominguez-Delgado, Clara Luisa [1 ,2 ]
Campos-Santander, Kenia Areli [1 ]
Benavides, Allyson Amelia [2 ]
Pacheco-Ortin, Sandy Maria [3 ]
Higuera-Piedrahita, Rosa Isabel [4 ]
Resendiz-Gonzalez, Guillermo [4 ]
Molina-Trinidad, Eva Maria [5 ]
机构：
[1] Univ Nacl Autonoma Mexico, Fac Estudios Super Cuautitlan, Dept Ingn & Tecnol, Secc Farm, Cuautitlan 54740, Estado De Mexic, Mexico
[2] Univ Texas Austin, Coll Pharm, Div Mol Pharmaceut & Drug Delivery, 2409 Univ Ave, Austin, TX 78712 USA
[3] Univ Nacl Autonoma Mexico, Fac Estudios Super Cuautitlan, Dept Ciencias Quim, Mexico City 54740, Mexico
[4] Univ Nacl Autonoma Mexico, Fac Estudios Super Cuautitlan, Unidad Invest Multidisciplinaria L 3, Carretera Cuautitlan Teoloyucan, Mexico City 54714, Mexico
[5] Univ Autonoma Estado Hidalgo, Area Academ Med, Inst Ciencias Salud, Ex Hacienda Concepc, Tilcuautla 42160, Hidalgo, Mexico
来源：
CURRENT PHARMACEUTICAL BIOTECHNOLOGY | 2023年 / 24卷 / 11期
关键词：
Skin anti-aging; nanotechnological strategies; skin permeation; nanocarriers; rejuvenation or anti-wrinkle effect; topical and transdermal delivery; herbal-based anti-aging actives; nanoparticles; SOLID LIPID NANOPARTICLES; DRUG-DELIVERY; HAIR FOLLICLE; IN-VITRO; PHYSICOCHEMICAL PROPERTIES; MECHANICAL-PROPERTIES; TRANSDERMAL DELIVERY; MOLECULAR-MECHANISMS; PEPTIDE DENDRIMERS; GOLD NANOPARTICLES;
D O I：
10.2174/1389201024666221223095315
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Background Nanoparticle formulations development for anti-aging treatment is increasingdue to their multifunctional properties. These nanotechnological strategies can target cellular/molecular pathways of the skin affected by the aging process. However, a review of these strategiesis required to discuss their efficacy/safety and establish the needs for further research.Objective: Innovative nanotechnological advances for skin anti-aging/rejuvenation are summarizedand discussed in this work. Methods The information in this review was extracted from recent and relevant studies usingnanotechnology for anti-aging treatment from scientific databases. Results and Discussion Results show an enhanced skin anti-aging effect of actives-loaded nanoparticlesof next generation (nanostructured lipid carriers, fullerenes, transfersomes, protransfersomes,niosomes, ethosomes, transethosomes, glycerosomes, phytosomes) compared withnanocarriers of first generation or conventional formulations. Anti-aging active ingredients such as,flavonoids (rutin, hesperidin, quercetagetine, quercetin, epigallocatechin-3-gallate, myricetin,silibinin, curcuminoids, isoflavones); vitamins (E, D3, CoQ10); acids (hyaluronic, ascorbic,rosmarinic, gallic); extracts (Citrus sinensis, Tagetes erecta L., Achillea millefolium L., Citrus aurantium L., Glycyrrhiza glabra L., Aloe vera, propolis earned by Apis mellifera); and othercompounds (adenosine, beta-glucan, heptapetide DEETGEF, resveratrol, cycloastragenol, melatonin,botulinum toxin, grapeseed oil), have been successfully entrapped into nanoparticles for skinrejuvenation. This encapsulation has improved their solubility, bioavailability, stability, permeability,and effectivity for skin anti-aging, providing a controlled drug release with minimized sideeffects. Conclusion Recent studies show a trend of anti-aging herbal active ingredients-loaded nanoparticles,enhancing the moisturizing, antioxidant, regenerating and photoprotective activity of the skin.Suitable safety/shelf-life stability of these novel formulations is key to a successful translation to theclinic/industry.
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页码：1397 / 1419
页数：23
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