Interplay between speech and gait variables in Parkinson's disease patients treated with subthalamic nucleus deep brain stimulation: A long-term instrumental assessment

被引：3

作者：

Cavallieri, Francesco ^{[1
,2
]}

Gessani, Annalisa ^{[3
]}

Merlo, Andrea ^{[4
,16
]}

Campanini, Isabella ^{[4
]}

Budriesi, Carla ^{[3
]}

Fioravanti, Valentina ^{[1
]}

Di Rauso, Giulia ^{[1
,3
]}

Feletti, Alberto ^{[5
,6
]}

Damiano, Benedetta ^{[4
]}

Scaltriti, Sara ^{[4
,8
]}

Guagnano, Noemi ^{[4
]}

Bardi, Elisa ^{[3
,9
]}

Corni, Maria Giulia ^{[3
]}

Antonelli, Francesca ^{[3
]}

Cavalleri, Francesca ^{[7
]}

Molinari, Maria Angela ^{[3
]}

Contardi, Sara

Menozzi, Elisa

Puzzolante, Annette ^{[6
]}

Vannozzi, Giuseppe ^{[10
]}

Bergamini, Elena ^{[10
]}

Pavesi, Giacomo ^{[6
]}

Fraix, Valerie ^{[11
]}

Meoni, Sara ^{[11
]}

Fraternali, Alessandro ^{[12
]}

Versari, Annibale ^{[12
]}

Lusuardi, Mirco ^{[13
]}

Biagini, Giuseppe ^{[14
]}

Pinto, Serge ^{[15
]}

Moro, Elena ^{[11
]}

Valzania, Franco ^{[1
]}

机构：

[1] Azienda USL IRCCS Reggio Emilia, Neuromotor & Rehabil Dept, Neurol Unit, Reggio Emilia, Italy

[2] Univ Modena & Reggio Emilia, Clin & Expt Med PhD Program, Modena, Italy

[3] Azienda Osped Univ Modena, S Agostino Estense Hosp, Dept Neurosci, Neurol Unit, Modena, Italy

[4] Azienda USL IRCCS Reggio Emilia, S Sebastiano Hosp, Neuromotor & Rehabil Dept, LAM Mot Anal Lab, Correggio, Italy

[5] Univ Verona, Inst Neurosurg, Dept Neurosci Biomed & Movement Sci, Verona, Italy

[6] Azienda Osped Univ Modena, Osped Civile Baggiovara OCB Hosp, Neurosurg Unit, Modena, Italy

[7] OCB Hosp, Dept Neurosci, Div Neuroradiol, Azienda Osped Univ Modena, Modena, Italy

[8] Osped Maggiore Bologna, IRCCS Ist Sci Neurol Bologna, Neurol & Rete Stroke Metropolitana, Bologna, Italy

[9] UCL Queen Sq Inst Neurol, Dept Clin & Movement Neurosci, London, England

[10] Univ Rome Foro Italico, Dept Movement Human & Hlth Sci, Lab Bioengn & Neuromech Movement, Rome, Italy

[11] Univ Grenoble Alpes, Grenoble Inst Neurosci, Neurol Dept, CHU Grenoble Alpes,Inserm,U1216, Grenoble, France

[12] Azienda Unita Sanit Locale IRCCS, Nucl Med Unit, Reggio Emilia, Italy

[13] Azienda USL IRCCS Reggio Emilia, Neuromotor & Rehabil Dept, Reggio Emilia, Italy

[14] Univ Modena & Reggio Emilia, Dept Biomed Metab & Neural Sci, Modena, Italy

[15] Aix Marseille Univ, CRNS, LPL, Aix En Provence, France

[16] Azienda USL IRCCS Reggio Emilia, S Sebastiano Hosp, Neuromotor & Rehabil Dept, LAM Mot Anal Lab, I-42015 Correggio, Italy

来源：

EUROPEAN JOURNAL OF NEUROLOGY | 2023年 / 30卷 / 07期

关键词：

deep brain stimulation; gait; levodopa; Parkinson's disease; speech; STN-DBS; IMPAIRMENT; DISORDERS; BALANCE; ACCURACY; WALKING; RHYTHM; FALLS;

D O I：

10.1111/ene.15803

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: To evaluate correlations between speech and gait parameters in the long term and under different medication and subthalamic nucleus deep brain stimulation (STN-DBS) conditions in a cohort of advanced Parkinson's disease (PD) patients.Methods: This observational study included consecutive PD patients treated with bilateral STN-DBS. Axial symptoms were evaluated using a standardized clinical-instrumental approach. Speech and gait were assessed by perceptual and acoustic analyses and by the instrumented Timed Up and Go (iTUG) test, respectively. Disease motor severity was evaluated with the total score and subscores of the Unified Parkinson's Disease Rating Scale (UPDRS) Part III. Different stimulation and drug treatment conditions were assessed: on-stimulation/off-medication, off-stimulation/off-medication, and on-stimulation/on-medication.Results: Twenty-five PD patients with a 5-year median follow-up after surgery (range 3-7 years) were included (18 males; disease duration at surgery: 10.44 [SD 4.62] years; age at surgery: 58.40 [SD 5.73] years). In the off-stimulation/off-medication and on-stimulation/on-medication conditions, patients who spoke louder had also the greater acceleration of the trunk during gait; whereas in the on-stimulation/on-medication condition only, patients with the poorer voice quality were also the worst to perform the sit to stand and gait phases of the iTUG. Conversely, patients with the higher speech rate performed well in the turning and walking phases of the iTUG.Conclusions: This study underlines the presence of different correlations between treatment effects of speech and gait parameters in PD patients treated with bilateral STN-DBS. This may allow us to better understand the common pathophysiological basis of these alterations and to develop a more specific and tailored rehabilitation approach for axial signs after surgery.

引用

页码：1963 / 1972

页数：10

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