The bidirectional relationship between endometriosis and microbiome

被引：33
作者：
Uzuner, Cansu [1 ]
Mak, Jason [1 ]
El-Assaad, Fatima [2 ]
Condous, George [1 ]
机构：
[1] Univ Sydney, Nepean Hosp, Sydney Med Sch Nepean, Endometriosis Ultrasound & Adv Endosurgery Unit, Sydney, NSW, Australia
[2] Univ New South Wales, Fac Med & Hlth, Microbiome Res Ctr, Sch Clin Med, St George & Sutherland Clin Campuses, Sydney, NSW, Australia
来源：
FRONTIERS IN ENDOCRINOLOGY | 2023年 / 14卷
关键词：
endometriosis; microbiome; microbiota; dysbiosis; inflammation; immune response; POLYUNSATURATED FATTY-ACIDS; FACTOR-KAPPA-B; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PATHOGENESIS; INSIGHTS; WOMEN; RISK; COLONIZATION; INFLAMMATION;
D O I：
10.3389/fendo.2023.1110824
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Endometriosis has been described by many different theories of pathogenesis over the years. It is now also appreciated to be a state of chronic inflammation, and the role of immune dysfunction in its development has been proven. There is increasing evidence to support the role of the microbiome in the formation and progression of endometriosis via inflammatory pathways. The dysbiosis seen in endometriosis is thought to be both causative and a consequence of the pathogenesis. Gut, peritoneal fluid and female reproductive tract microbiota has been studied to understand if there are any microbiome signatures specific to endometriosis. New research on how to manipulate the microbiome for better detection and treatment of endometriosis is emerging.
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页数：9
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