Polyunsaturated Fatty Acids and Their Immunomodulatory Actions in Periodontal Disease

被引：7
作者：
Panezai, Jeneen [1 ,2 ]
van Dyke, Thomas [1 ,3 ,4 ]
机构：
[1] Forsyth Inst, Dept Appl Oral Sci, Cambridge, MA 02142 USA
[2] Balochistan Univ Informat Technol Engn & Managemen, Fac Life Sci & Informat, Dept Microbiol, Quetta 87300, Pakistan
[3] Forsyth Inst, Ctr Clin & Translat Res, Cambridge, MA 02142 USA
[4] Harvard Fac Med, Dept Oral Med Infect & Immun, Boston, MA 02115 USA
来源：
NUTRIENTS | 2023年 / 15卷 / 04期
关键词：
fatty acids; periodontitis; inflammation; TUMOR-NECROSIS-FACTOR; NF-KAPPA-B; GAMMA-LINOLENIC ACID; T-LYMPHOCYTE PROLIFERATION; ACTIVATED-RECEPTOR-GAMMA; DOCOSAHEXAENOIC ACID; ARACHIDONIC-ACID; FISH-OIL; OSTEOCLAST DIFFERENTIATION; EICOSAPENTAENOIC ACID;
D O I：
10.3390/nu15040821
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Polyunsaturated fatty acids (PUFAs) are a diverse set of molecules with remarkable contributions to human physiology. They not only serve as sources of fuel but also cellular structural components as well as substrates that provide bioactive metabolites. A growing body of evidence demonstrates their role in inflammation. Inflammation in the presence of a polymicrobial biofilm contributes to the pathology of periodontitis. The role PUFAs in modulating immuno-inflammatory reactions in periodontitis is only beginning to be uncovered as research continues to unravel their far-reaching immunologic implications.
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页数：15
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