Novel phenolic metabolites isolated from plant endophytic fungus Fusarium guttiforme

被引：4

作者：

Yue, Jing-Yi ^{[1
]}

Wang, Rui ^{[1
]}

Xu, Tao ^{[2
]}

Wang, Ju-Tao ^{[3
,4
]}

Yu, Yang ^{[3
,5
]}

Cai, Bai-Xiang ^{[3
,5
]}

机构：

[1] Wuhu Inst Technol, Wuhu, Peoples R China

[2] West Anhui Univ, Dept Biol & Pharmaceut Engn, Luan, Peoples R China

[3] Anhui Univ Chinese Med, Sch Pharm, Hefei, Peoples R China

[4] Anhui Prov Key Lab Res & Dev Chinese Med, Hefei, Peoples R China

[5] Anhui Acad Chinese Med, Inst Med Chem, Hefei, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2024年 / 38卷 / 02期

关键词：

Fusarium guttiforme; phenolic metabolites; nitric oxide; inhibitory activity; SOLANI;

D O I：

10.1080/14786419.2022.2116579

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new phenolic compounds Fusagunolics A (1) and B (2) were isolated from the plant endophytic fungus Fusarium guttiforme, in addition to the previously known metabolites (3-6). The structures of these compounds was elucidated using a combination of spectroscopic analyses, including UV, HRESIMS, 1 D, and 2 D NMR, as well as electronic circular dichroism (ECD) and the optical rotatory dispersion (ORD). Further, the anti-inflammatory activity of all the compounds was evaluated to assess their capability to inhibit nitric oxide (NO) production by RAW 264.7 macrophages. The bioactive screening revealed that compounds 2 and 6 exhibited moderate inhibitory effects against NO production with the IC50 values 28.6 and 37.6 mu M, respectively.

引用

页码：336 / 340

页数：5

共 50 条

[41] Secondary Metabolites from Phomopsis amygdali, an Endophytic Fungus Isolated from Hazelnut (Corylus avellana)
Akay, S.
Ekiz, G.
Kocabas, F.
Kocabas, E.
Korkmaz, K. S.
Bedir, E.
PLANTA MEDICA, 2011, 77 (12) : 1286 - 1287
[42] Bioactive metabolites produced by Chaetomium globosum, an endophytic fungus isolated from Ginkgo biloba
Qin, Jian-Chun
Zhang, Ya-Mei
Gao, Jin-Ming
Bai, Ming-Sheng
Yang, Sheng-Xiang
Laatsch, Hartmut
Zhang, An-Ling
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (06) : 1572 - 1574
[43] Novel polyketides isolated from cultures of an endophytic fungus, Annulohypoxylon truncatum
Li, W.
Lee, C.
Bang, S. H.
Kim, S.
Xia, X.
Shim, S. H.
PLANTA MEDICA, 2016, 82
[44] Phytotoxic Metabolites Isolated from Aspergillus sp., an Endophytic Fungus of Crassula arborescens
Ma, Jingjing
Lu, Chunhua
Tang, Yajie
Shen, Yuemao
MOLECULES, 2022, 27 (22):
[45] Annularins I and J: New Metabolites Isolated from Endophytic Fungus Exserohilum rostratum
Pinheiro, Eduardo A. A.
Borges, Fabio C.
Pina, Jeferson R. S.
Ferreira, Leila R. S.
Cordeiro, Jorgeffson S.
Carvalho, Josiwander M.
Feitosa, Andre O.
Campos, Francinete R.
Barison, Andersson
Souza, Afonso D. L.
Marinho, Patricia S. B.
Marinho, Andrey M. R.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 2016, 27 (08) : 1432 - 1436
[46] Chemoreversal Metabolites from the Endophytic Fungus Penicillium citrinum Isolated from a Mangrove Avicennia marina
Liu, Jin
Xu, Meng
Zhu, Ming-yi
Feng, Yun
NATURAL PRODUCT COMMUNICATIONS, 2015, 10 (07) : 1203 - 1205
[47] Novel Metabolites from the Endophytic Fungus Chaetomium subaffine L01
Han, Xiao-Yang
Xie, Yi-Xuan
Wu, Chao-Qun
Ai, Hong-Lian
Lei, Xin-Xiang
Wang, Xiang-Jing
CHEMISTRY & BIODIVERSITY, 2019, 16 (12)
[48] Molecular characterization of a novel mycovirus of the family Tymoviridae isolated from the plant pathogenic fungus Fusarium graminearum
Li, Pengfei
Lin, Yanhong
Zhang, Hailong
Wang, Shuangchao
Qiu, Dewen
Guo, Lihua
VIROLOGY, 2016, 489 : 86 - 94
[49] Abundant novel secondary metabolites from a marine algous endophytic fungus and their bioactivity
Zhang, Yi
Mu, Jun
Guo, Zhen
Yan, Song
Lu, Hongli
JOURNAL OF BIOTECHNOLOGY, 2008, 136 : S599 - S599
[50] Bioactive compounds from the endophytic fungus Fusarium proliferatum
Dame, Zerihun T.
Silima, Beauty
Gryzenhout, Marieka
van Ree, Teunis
NATURAL PRODUCT RESEARCH, 2016, 30 (11) : 1301 - 1304

← 1 2 3 4 5 →