Novel phenolic metabolites isolated from plant endophytic fungus Fusarium guttiforme

被引：4

作者：

Yue, Jing-Yi ^{[1
]}

Wang, Rui ^{[1
]}

Xu, Tao ^{[2
]}

Wang, Ju-Tao ^{[3
,4
]}

Yu, Yang ^{[3
,5
]}

Cai, Bai-Xiang ^{[3
,5
]}

机构：

[1] Wuhu Inst Technol, Wuhu, Peoples R China

[2] West Anhui Univ, Dept Biol & Pharmaceut Engn, Luan, Peoples R China

[3] Anhui Univ Chinese Med, Sch Pharm, Hefei, Peoples R China

[4] Anhui Prov Key Lab Res & Dev Chinese Med, Hefei, Peoples R China

[5] Anhui Acad Chinese Med, Inst Med Chem, Hefei, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2024年 / 38卷 / 02期

关键词：

Fusarium guttiforme; phenolic metabolites; nitric oxide; inhibitory activity; SOLANI;

D O I：

10.1080/14786419.2022.2116579

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new phenolic compounds Fusagunolics A (1) and B (2) were isolated from the plant endophytic fungus Fusarium guttiforme, in addition to the previously known metabolites (3-6). The structures of these compounds was elucidated using a combination of spectroscopic analyses, including UV, HRESIMS, 1 D, and 2 D NMR, as well as electronic circular dichroism (ECD) and the optical rotatory dispersion (ORD). Further, the anti-inflammatory activity of all the compounds was evaluated to assess their capability to inhibit nitric oxide (NO) production by RAW 264.7 macrophages. The bioactive screening revealed that compounds 2 and 6 exhibited moderate inhibitory effects against NO production with the IC50 values 28.6 and 37.6 mu M, respectively.

引用

页码：336 / 340

页数：5

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