Measurable residual disease conversion rate with consolidation chemotherapy in acute myeloid leukemia

被引：3

作者：

Gaut, Daria ^{[1
,8
]}

Oliai, Caspian ^{[1
]}

Boiarsky, Jonathan ^{[1
]}

Zhang, Shiliang ^{[1
]}

Salhotra, Amandeep ^{[2
]}

Azenkot, Tali ^{[3
]}

Kennedy, Vanessa E. ^{[4
]}

Khanna, Vishesh ^{[5
]}

Olmedo Gutierrez, Karla ^{[6
]}

Shukla, Navika ^{[7
]}

Moskoff, Benjamin ^{[3
]}

Park, Gabriel ^{[2
]}

Afkhami, Michelle ^{[2
]}

Patel, Anand ^{[7
]}

Jeyakumar, Deepa ^{[6
]}

Mannis, Gabriel ^{[5
]}

Logan, Aaron C. ^{[4
]}

Jonas, Brian A. ^{[3
]}

Schiller, Gary ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Hematol Oncol, Los Angeles, CA 90095 USA

[2] City Hope Natl Med Ctr, Dept Hematol & Hematopoiet Cell Transplant, Duarte, CA USA

[3] Univ Calif Davis, Dept Med, Div Hematol Oncol, Sch Med, Sacramento, CA USA

[4] Univ Calif San Francisco, Sch Med, Dept Med, Div Hematol Oncol, San Francisco, CA USA

[5] Stanford Canc Inst, Dept Med, Div Hematol, Stanford, CA USA

[6] Univ Calif Irvine, Sch Med, Dept Med, Div Hematol Oncol, Orange, CA USA

[7] Univ Chicago, Dept Med, Div Hematol Oncol, Chicago, IL USA

[8] Univ Calif Los Angeles, David Geffen Sch Med, 200 UCLA Med Plaza,Suite 120, Los Angeles, CA 90095 USA

来源：

LEUKEMIA & LYMPHOMA | 2024年 / 65卷 / 01期

关键词：

Acute myeloid leukemia; measurable residual disease; consolidation chemotherapy; allogeneic hematopoietic stem cell transplantation; HEMATOPOIETIC-CELL TRANSPLANTATION; MULTIPARAMETER FLOW-CYTOMETRY; COMPLETE REMISSION; OLDER PATIENTS; IMPACT; MRD; AML; HOVON/SAKK; INDUCTION; SURVIVAL;

D O I：

10.1080/10428194.2023.2264426

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The rate of MRD clearance in AML with standard consolidation chemotherapy is not well defined. A multi-institution retrospective analysis was performed on 107 consecutively treated AML patients in morphologic complete remission with detectable MRD post-induction therapy who received standard chemotherapy consolidation. In response to standard intermediate/high-dose cytarabine consolidation therapy, 26 of 60 patients (43.3%) with MRD threshold of detection of at least 0.1% converted to MRD-negative status (undetectable with assay used), and 6 of 47 patients (12.8%) with MRD threshold of detection > 0.1% converted to MRD-negative status. Multivariable logistic regression for patients with MRD threshold of detection of at least 0.1% showed that, when controlling for age, ELN risk category, dose of cytarabine, and use of a combination agent, treatment with 1 cycle of consolidation cytarabine versus >= 2 cycles decreased the odds of conversion of AML to MRD-negative (OR = 0.24, 95% CI 0.07-0.85, p = 0.03).

引用

页码：69 / 77

页数：9

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