Cancer-associated fibroblasts: tumor defenders in radiation therapy

被引：22

作者：

Zhang, Yalin ^{[1
]}

Lv, Na ^{[1
]}

Li, Manshi ^{[1
]}

Liu, Ming ^{[2
]}

Wu, Chunli ^{[1
]}

机构：

[1] China Med Univ, Dept Radiat Oncol, Affiliated Hosp 4, Shenyang, Liaoning, Peoples R China

[2] China Med Univ, Dept Clin Epidemiol, Affiliated Hosp 4, Shenyang, Liaoning, Peoples R China

来源：

CELL DEATH & DISEASE | 2023年 / 14卷 / 08期

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; STROMAL FIBROBLASTS; IONIZING-RADIATION; MICROARRAY ANALYSIS; GENE-EXPRESSION; CELL PHENOTYPE; RADIOTHERAPY; GROWTH; IMMUNOTHERAPY; LINEAGE;

D O I：

10.1038/s41419-023-06060-z

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cancer-associated fibroblasts (CAFs) are an important component of the tumor microenvironment that are involved in multiple aspects of cancer progression and considered contributors to tumor immune escape. CAFs exhibit a unique radiation resistance phenotype, and can survive clinical radiation doses; however, ionizing radiation can induce changes in their secretions and influence tumor progression by acting on tumor and immune cells. In this review, we describe current knowledge of the effects of radiation therapies on CAFs, as well as summarizing understanding of crosstalk among CAFs, tumor cells, and immune cells. We highlight the important role of CAFs in radiotherapy resistance, and discuss current and future radiotherapy strategies for targeting CAFs.

引用

页数：8

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