Biginelli Reaction in the Synthesis of Ethyl 4-(6-Aryl-5-benzoyl-4-hydroxy-2-thioxohexahydropyrimidine-4-carboxamido)benzoates

被引：1

作者：

Gein, V. L. ^{[1
]}

Zamaraeva, T. M. ^{[1
]}

Gorgopina, E. V. ^{[1
]}

Dmitriev, M. V. ^{[2
]}

机构：

[1] Perm State Pharmaceut Acad, Perm 614990, Russia

[2] Perm State Natl Res Univ, Perm 614990, Russia

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2023年 / 93卷 / 01期

关键词：

Biginelli reaction; ethyl 4-(2; 4-dioxo-4-phenylbutanamido)benzoate; arylaldehydes; thiourea; sodium acetate;

D O I：

10.1134/S1070363223010036

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Three-component Biginelli reaction of ethyl 4-(2,4-dioxo-4-phenylbutanamido)benzoate, aromatic aldehyde and thiourea in acetic acid in the presence of sodium acetate led to the formation of ethyl 4-(6-aryl-5-benzoyl-4-hydroxy-2-thioxohexahydropyrimidine-4-carboxamido)benzoates. Structure of the obtained compounds was established by IR, H-1 NMR, C-13 spectroscopy methods.

引用

页码：16 / 21

页数：6