Amylin in Alcohol Addiction: A Potential New Treatment Target or an Adjuvant to Other Treatments?

被引：3
|
作者：
Boukabara, Selim [1 ]
Farokhnia, Mehdi [1 ,2 ]
Leggio, Lorenzo [1 ,3 ,4 ,5 ]
机构：
[1] NIDA, Clin Psychoneuroendocrinol & Neuropsychopharmacol, Translat Addict Med Branch, Intramural Res Program,NIH, Baltimore, MD 21224 USA
[2] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mental Hlth, Baltimore, MD 21205 USA
[3] Johns Hopkins Univ, Sch Med, Dept Med, Div Addict Med, Baltimore, MD 21218 USA
[4] Brown Univ, Sch Publ Hlth, Dept Behav & Social Sci, Ctr Alcohol & Addict Studies, Providence, RI 02912 USA
[5] Georgetown Univ Med Ctr, Dept Neurosci, Washington, DC 20057 USA
来源：
ACS CHEMICAL NEUROSCIENCE | 2024年 / 15卷 / 08期
基金：
美国国家卫生研究院;
关键词：
Amylin; calcitonin; alcohol; addiction; dopamine; serotonin;
D O I：
10.1021/acschemneuro.4c00133
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Amylin is a neuroendocrine hormone with a potential role in addictive disorders, including alcohol use disorder (AUD). In addition to reducing appetitive behavior, amylin has been shown to affect alcohol-related behaviors in rodents. Delineating the biobehavioral correlates of amylin in relation to alcohol seeking and consumption has the potential of identifying new treatment targets for AUD, yet additional translational and human research is needed.
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页码：1609 / 1610
页数：2
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