Systematic review and meta-analyses on the accuracy of diagnostic tests for IgE-mediated food allergy

被引：53

作者：

Riggioni, Carmen ^{[2
,3
]}

Ricci, Cristian ^{[4
]}

Moya, Beatriz ^{[5
,6
]}

Wong, Dominic ^{[7
]}

van Goor, Evi ^{[7
,8
,9
]}

Bartha, Irene ^{[7
,10
]}

Buyuktiryaki, Betul ^{[11
]}

Giovannini, Mattia ^{[12
,13
]}

Jayasinghe, Sashini ^{[7
]}

Jaumdally, Hannah ^{[7
,14
]}

Marques-Mejias, Andreina ^{[7
,10
]}

Piletta-Zanin, Alexandre ^{[15
]}

Berbenyuk, Anna ^{[16
]}

Andreeva, Margarita ^{[16
]}

Levina, Daria ^{[16
]}

Iakovleva, Ekaterina ^{[16
]}

Roberts, Graham ^{[17
,18
,19
]}

Chu, Derek ^{[20
]}

Peters, Rachel ^{[21
,22
]}

du Toit, George ^{[7
,10
]}

Skypala, Isabel ^{[23
,24
]}

Santos, Alexandra F. ^{[1
,7
,10
,14
,25
]}

机构：

[1] St ThomasHospital, Dept Paediat Allergy, 2nd floor, South Wing, London SE1 7EH, England

[2] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Paediat, Singapore City, Singapore

[3] Khoo Teck Puat Natl Univ, Natl Univ Hosp, Natl Univ Hlth Syst, Childrens Med Inst, Singapore City, Singapore

[4] North West Univ, Afr Unit Transdisciplinary Hlth Res AUTHeR, Potchefstroom, South Africa

[5] Hosp Univ 12 Octubre, Dept Allergy, 12 Octubre, Madrid, Spain

[6] Hosp 12 Octubre Imas 12, Inst Invest Sanitaria, Madrid, Spain

[7] Kings Coll London, Fac Life Sci & Med, Sch Life Course Sci, Dept Women & Childrens Hlth, London, England

[8] Kings Coll London, Fac Life Sci & Med, Sch Life Course Sci, Dept Women & Childrens Hlth, London, England

[9] Elkerliek Hosp, Helmond, Netherlands

[10] Evelina London Childrens Hosp, Guys & St ThomasHospital, Childrens Allergy Serv, London, England

[11] Koc Univ, Sch Med, Dept Pediat, Div Pediat Allergy, Istanbul, Turkiye

[12] Meyer Childrens Hosp IRCCS, Allergy Unit, Florence, Italy

[13] Univ Florence, Dept Hlth Sci, Florence, Italy

[14] Kings Coll London, Sch Immunol & Microbial Sci, Peter Gorer Dept Immunobiol, London, England

[15] Geneva Univ Hosp, Div Pediat Specialties, Dept Women Children & Adolescents, Geneva, Switzerland

[16] Sechenov Univ, Sechenov First Moscow State Med Univ, Inst Childs Hlth, Dept Paediat & Paediat Infect Dis, Moscow, Russia

[17] Univ Southampton, Fac Med, Clin & Expt Sci & Human Dev & Hlth, Southampton, England

[18] Univ Hosp Southampton NHS Fdn Trust, NIHR Southampton Biomed Res Ctr, Southampton, England

[19] St Marys Hosp, David Hide Asthma & Allergy Res Ctr, Newport, England

[20] McMaster Univ, Dept Med, Hamilton, ON, Canada

[21] Murdoch Childrens Res Inst Melbourne, Melbourne, Vic, Australia

[22] Univ Melbourne, Dept Paediat, Melbourne, Vic, Australia

[23] Imperial Coll London, Natl Heart & Lung Inst, London, England

[24] Royal Brompton & Harefield NHS Fdn Trust, Royal Brompton Hosp, Dept Allergy & Clin Immunol, London, England

[25] St Thomas Hosp, Dept Paediat Allergy, 2nd floor, South Wing, London SE1 7EH, England

来源：

ALLERGY | 2024年 / 79卷 / 02期

基金：

英国医学研究理事会;

关键词：

basophil activation test; component-resolved diagnostics; diagnosis; diagnostic tests; food allergy; IgE-mediated; sensitivity; skin prick test; specific IgE; specificity; ARA H 2; SKIN PRICK TEST; COMPONENT-RESOLVED DIAGNOSTICS; COWS MILK ALLERGY; EXERCISE-INDUCED ANAPHYLAXIS; PREDICT PEANUT ALLERGY; SOUTH-AFRICAN CHILDREN; HAZELNUT ALLERGY; BAKED-EGG; IMMUNOGLOBULIN-E;

D O I：

10.1111/all.15939

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The European Academy of Allergy and Clinical Immunology (EAACI) is updating the Guidelines on Food Allergy Diagnosis. We aimed to undertake a systematic review of the literature with meta-analyses to assess the accuracy of diagnostic tests for IgE-mediated food allergy. We searched three databases (Cochrane CENTRAL (Trials), MEDLINE (OVID) and Embase (OVID)) for diagnostic test accuracy studies published between 1 October 2012 and 30 June 2021 according to a previously published protocol (CRD42021259186). We independently screened abstracts, extracted data from full texts and assessed risk of bias with QUADRAS 2 tool in duplicate. Meta-analyses were undertaken for food-test combinations for which three or more studies were available. A total of 149 studies comprising 24,489 patients met the inclusion criteria and they were generally heterogeneous. 60.4% of studies were in children <= 12 years of age, 54.3% were undertaken in Europe, >= 95% were conducted in a specialized paediatric or allergy clinical setting and all included oral food challenge in at least a percentage of enrolled patients, in 21.5% double-blind placebo-controlled food challenges. Skin prick test (SPT) with fresh cow's milk and raw egg had high sensitivity (90% and 94%) for milk and cooked egg allergies. Specific IgE (sIgE) to individual components had high specificity: Ara h 2-sIgE had 92%, Cor a 14-sIgE 95%, Ana o 3-sIgE 94%, casein-sIgE 93%, ovomucoid-sIgE 92/91% for the diagnosis of peanut, hazelnut, cashew, cow's milk and raw/cooked egg allergies, respectively. The basophil activation test (BAT) was highly specific for the diagnosis of peanut (90%) and sesame (93%) allergies. In conclusion, SPT and specific IgE to extracts had high sensitivity whereas specific IgE to components and BAT had high specificity to support the diagnosis of individual food allergies.

引用

页码：324 / 352

页数：29

共 182 条

[121] Gal d 1-specific IgE predicts allergy to heated egg in Finnish children [J].