OVERALL AND CANCER-SPECIFIC SURVIVAL OF HIGH-RISK PROSTATE CANCER - IMPACT OF ADJUVANT THERAPY AFTER RADICAL PROSTATECTOMY

被引:0
作者
Ganev, Tosho [1 ,2 ]
机构
[1] Med Univ Varna, Fac Med, Dept Surg, MHAT Sveta Anna,Clin Urol, Varna, Bulgaria
[2] Med Univ Varna, Dept Surg, Clin Urol, MHAT Sveta Anna Varna, 100 Tzar Osvoboditel Blvd, Varna 9000, Bulgaria
关键词
hormonal therapy; radiotherapy; Gleason score; MULTIMODAL TREATMENT; SCORE;
D O I
10.5272/jimab.2023294.5188
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose: The study examines the survival of patients with high-risk prostate cancer in order to find a relationship between survival and the type of postoperative therapy.Materials/Methods: The object of the study were 872 patients who underwent radical prostatectomy in the Clinic of Urology in "St. Anna Varna" Hospital for the period from April 17, 1996, until November 25, 2022. Postoperatively, some patients were additionally subjected to hormonal therapy (referred to as "dual therapy" in the text), and others to hormonal and radiotherapy (referred to as "triple therapy").Results: Overall and cancer-specific survival of high risk patients did not differ statistically significantly for the two types of postoperative therapy.Conclusions: The optimal combination of radical prostatectomy, hormonal and radiotherapy in order to achieve maximum survival for patients with high-risk prostate cancer is still poorly defined.
引用
收藏
页码:5188 / 5191
页数:4
相关论文
共 11 条
[1]   The Moving Landscape of Locally Advanced Prostate Cancer: Combination of External Irradiation and Endocrine Treatment and/or Multimodal Approach [J].
Bolla, Michel .
EUROPEAN UROLOGY, 2012, 62 (02) :220-221
[2]   The University of California, San Francisco cancer of the prostate risk assessment score: A straightforward and reliable preoperative predictor of disease recurrence after radical prostatectomy [J].
Cooperberg, MR ;
Pasta, DJ ;
Elkin, EP ;
Litwin, MS ;
Latini, DM ;
DuChane, J ;
Carroll, PR .
JOURNAL OF UROLOGY, 2005, 173 (06) :1938-1942
[3]   Androgen suppression and radiation vs radiation alone for prostate cancer - A randomized trial [J].
D'Amico, Anthony V. ;
Chen, Ming-Hui ;
Renshaw, Andrew A. ;
Loffredo, Marian ;
Kantoff, Philip W. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2008, 299 (03) :289-295
[4]   Poorly differentiated prostate cancer treated with radical prostatectomy: Long-term outcome and incidence of pathological downgrading [J].
Donohue, John F. ;
Bianco, Fernando J., Jr. ;
Kuroiwa, Kentaro ;
Vickers, Andrew J. ;
Wheeler, Thomas M. ;
Scardino, Peter T. ;
Reuter, Victor A. ;
Eastham, James A. .
JOURNAL OF UROLOGY, 2006, 176 (03) :991-995
[5]   Concordance Between Biopsy and Radical Prostatectomy Pathology in the Era of Targeted Biopsy: A Systematic Review and Meta-analysis [J].
Goel, Shokhi ;
Shoag, Jonathan E. ;
Gross, Michael D. ;
Al Awamlh, Bashir Al Hussein ;
Robinson, Brian ;
Khani, Francesca ;
Nelson, Becky Baltich ;
Margolis, Daniel J. ;
Hu, Jim C. .
EUROPEAN UROLOGY ONCOLOGY, 2020, 3 (01) :10-20
[6]  
Lazarov B, 2022, Bulgarian Clinical urology, V2, P5
[7]  
Lazarov B, 2022, TRAKIA J SCI, V20, P146, DOI DOI 10.15547/tjs.2022.02.010
[8]  
Lazarov B, 2023, Bulgarian Varna Medical Forum, V12, P147
[9]  
Lazarov B, 2022, Bulgarian Clinical urology, V2, P11
[10]   Multimodal treatment of high-risk and locally advanced prostate cancer [J].
Preisser, Felix ;
Tilki, Derya .
UROLOGIE, 2022, 61 (12) :1341-1344