Pathogenesis and novel therapeutics of regulatory T cell subsets and interleukin-2 therapy in systemic lupus erythematosus

被引：11
作者：
Tsai, Yi-Giien [1 ,2 ,3 ,4 ]
Liao, Pei-Fen [3 ,5 ]
Hsiao, Kai-Hung [6 ]
Wu, Hung-Ming [7 ]
Lin, Ching-Yuang [8 ]
Yang, Kuender D. [9 ,10 ]
机构：
[1] Changhua Christian Childrens Hosp, Dept Pediat, Changhua, Taiwan
[2] Kaohsiung Med Univ, Sch Med, Kaohsiung 807, Kaohsiung, Taiwan
[3] Chung Shan Med Univ, Sch Med, Taichung, Taiwan
[4] Natl Chung Hsing Univ, Coll Med, Dept Postbaccalaureate Med, Taichung, Taiwan
[5] Chung Shan Med Univ Hosp, Dept Pediat, Div Allergy Asthma & Rheumatol, Taichung, Taiwan
[6] Changhua Christian Hosp, Dept Allergy Immunol & Rheumatol, Changhua, Taiwan
[7] Changhua Christian Hosp, Dept Neurol, Changhua, Taiwan
[8] China Med Univ Hosp, Childrens Hosp, Div Pediat Nephrol, Taichung, Taiwan
[9] MacKay Mem Hosp, Dept Pathol, New Taipei City, Taiwan
[10] Natl Yang Ming Chiao Tung Univ, Inst Clin Med, Taipei, Taiwan
来源：
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
关键词：
systemic lupus erythematosus; lupus nephritis; regulatory T cells; interleukin-2; B regulatory cells; LOW-DOSE IL-2; B-CELLS; DISEASE-ACTIVITY; CD4(+); ACTIVATION; FOXP3; DIFFERENTIATION; SUPPRESSION; ASSOCIATION; CAPACITY;
D O I：
10.3389/fimmu.2023.1230264
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Systemic lupus erythematosus (SLE) is a heterogeneous multisystem inflammatory disease with wide variability in clinical manifestations. Natural arising CD4+ regulatory T cells (Tregs) play a critical role in maintaining peripheral tolerance by suppressing inflammation and preventing autoimmune responses in SLE. Additionally, CD8+ regulatory T cells, type 1 regulatory T cells (Tr1), and B regulatory cells also have a less well-defined role in the pathogenesis of SLE. Elucidation of the roles of various Treg subsets dedicated to immune homeostasis will provide a novel therapeutic approach that governs immune tolerance for the remission of active lupus. Diminished interleukin (IL)-2 production is associated with a depleted Treg cell population, and its reversibility by IL-2 therapy provides important reasons for the treatment of lupus. This review focuses on the pathogenesis and new therapeutics of human Treg subsets and low-dose IL-2 therapy in clinical benefits with SLE.
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页数：13
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