Maternal Omega-3 Supplementation During Pregnancy, but Not Childhood Supplementation, Reduces the Risk of Food Allergy Diseases in Offspring

被引：4

作者：

Huynh, Linh Ba Phuong ^{[1
]}

Nguyen, Nam Nhat ^{[2
]}

Fan, Hsien-Yu ^{[3
,4
,5
]}

Huang, Shih-Yi ^{[1
,6
,7
]}

Huang, Chung-Hsiung ^{[8
]}

Chen, Yang -Ching ^{[1
,3
,5
,6
,7
,9
]}

机构：

[1] Taipei Med Univ, Sch Nutr & Hlth Sci, Taipei, Taiwan

[2] Taipei Med Univ, Coll Med, Taipei, Taiwan

[3] Taipei Med Univ, Taipei Med Univ Hosp, Dept Family Med, Taipei, Taiwan

[4] Natl Taiwan Univ, Inst Epidemiol & Prevent Med, Taipei, Taiwan

[5] Taipei Med Univ, Coll Med, Sch Med, Dept Family Med, Taipei, Taiwan

[6] Taipei Med Univ, Grad Inst Metab & Obes Sci, Taipei, Taiwan

[7] Taipei Med Univ Hosp, Nutr Res Ctr, Taipei, Taiwan

[8] Natl Taiwan Ocean Univ, Dept Food Sci, Keelung, Taiwan

[9] Taipei Med Univ, Taipei Med Univ Hosp, Dept Family Med, 252, Wuxing St, Taipei 110, Taiwan

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE | 2023年 / 11卷 / 09期

关键词：

Maternal; Omega-3; supplementation; Food allergy; Children; Meta-analysis; FISH-OIL SUPPLEMENTATION; CLINICAL-OUTCOMES; IMMUNE-RESPONSES; INFANTS; ASTHMA; SENSITIZATION; METAANALYSIS; MICROBIOME; PREVALENCE; LACTATION;

D O I：

10.1016/j.jaip.2023.06.005

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

BACKGROUND: Omega-3 supplementation has been reported to modulate immune responses and prevent food allergies among children; however, findings are inconsistent, and the timing of supplementation, which is critical, has not been thoroughly investigated. OBJECTIVE: To assess optimal timing (maternal vs childhood intake) of omega-3 supplementation for reducing food allergy risk among children in 2 periods (the first 3 years and beyond 3 years of age). METHODS: We performed a meta-analysis to assess the effects of maternal or childhood omega-3 supplementation on preventing the development of infant food allergies and food sensitizations. The PubMed/MEDLINE, Embase, Scopus, and Web of Science databases were searched for related studies published until October 30, 2022. We conducted dose-response and subgroup analyses to investigate the effects of omega-3 supplementation. RESULTS: We found that maternal omega-3 supplementation during pregnancy and lactation was significantly associated with decreased risks of infant egg sensitization (relative risk [RR]: 0.58, 95% confidence interval [95% CI]: 0.47-0.73, P <.01) and peanut sensitization (RR: 0.62, 95% CI: 0.47-0.80, P <.01) among children. Similar results were found in subgroup analyses for food allergy, egg sensitization, and peanut sensitization during the first 3 years of age and peanut sensitization and cashew nut sensitization beyond 3 years of age. Dose-response analysis showed a linear relationship between maternal omega-3 supplementation and infant egg sensitization risk during early life. By contrast, intake of omega-3 polyunsaturated fatty acid during childhood did not appear to significantly protect against food allergies. CONCLUSIONS: Maternal omega-3 supplementation during pregnancy and lactation, rather than childhood intake, reduces the risk of infant food allergy and food sensitization. (C) 2023 American Academy of Allergy, Asthma & Immunology

引用

页码：2862 / 2871.e8

页数：18

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